Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration
Neal, Matthew L, Fleming, Sheila M, Budge, Kevin M, Boyle, Alexa M, Kim, Chunki, Alam, Gelareh, Beier, Eric E, Wu, Long-Jun, Richardson, Jason R
Published in The FASEB journal (01.01.2020)
Published in The FASEB journal (01.01.2020)
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Journal Article
Assessment of sensorimotor function in mouse models of Parkinson's disease
Fleming, Sheila M, Ekhator, Osunde R, Ghisays, Valentins
Published in Journal of visualized experiments (17.06.2013)
Published in Journal of visualized experiments (17.06.2013)
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Journal Article
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.
Published in Neurobiology of disease (01.10.2019)
Published in Neurobiology of disease (01.10.2019)
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Journal Article
Olfactory assays for mouse models of neurodegenerative disease
Lehmkuhl, Andrew M, Dirr, Emily R, Fleming, Sheila M
Published in Journal of visualized experiments (25.08.2014)
Published in Journal of visualized experiments (25.08.2014)
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Journal Article
Farey Trees Explain Sequential Effects in Choice Response Time
Annand, Colin T, Fleming, Sheila M, Holden, John G
Published in Frontiers in physiology (17.03.2021)
Published in Frontiers in physiology (17.03.2021)
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Journal Article
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system
Gombash, Sara E, Manfredsson, Fredric P, Kemp, Christopher J, Kuhn, Nathan C, Fleming, Sheila M, Egan, Ann E, Grant, Laura M, Ciucci, Michelle R, MacKeigan, Jeffrey P, Sortwell, Caryl E
Published in PloS one (27.11.2013)
Published in PloS one (27.11.2013)
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Journal Article
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
Surmeier, D James, Chan, C Savio, Glajch, Kelly E, Gertler, Tracy S, Guzman, Jaime N, Mercer, Jeff N, Lewis, Alan S, Goldberg, Alan B, Tkatch, Tatiana, Shigemoto, Ryuichi, Fleming, Sheila M, Chetkovich, Dane M, Osten, Pavel, Kita, Hitoshi
Published in Nature neuroscience (01.01.2011)
Published in Nature neuroscience (01.01.2011)
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Journal Article
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits
Gezer, Aysegul O., Kochmanski, Joseph, VanOeveren, Sarah E., Cole-Strauss, Allyson, Kemp, Christopher J., Patterson, Joseph R., Miller, Kathryn M., Kuhn, Nathan C., Herman, Danielle E., McIntire, Alyssa, Lipton, Jack W., Luk, Kelvin C., Fleming, Sheila M., Sortwell, Caryl E., Bernstein, Alison I.
Published in Neurobiology of disease (01.07.2020)
Published in Neurobiology of disease (01.07.2020)
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Journal Article
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein
Dirr, Emily R., Ekhator, Osunde R., Blackwood, Rachel, Holden, John G., Masliah, Eliezer, Schultheis, Patrick J., Fleming, Sheila M.
Published in Behavioural brain research (02.05.2018)
Published in Behavioural brain research (02.05.2018)
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Journal Article
iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology
Peng, Yanyan, Liou, Benjamin, Lin, Yi, Mayhew, Christopher N., Fleming, Sheila M., Sun, Ying
Published in Molecular therapy. Methods & clinical development (08.06.2023)
Published in Molecular therapy. Methods & clinical development (08.06.2023)
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Journal Article
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
Goldberg, Matthew S., Fleming, Sheila M., Palacino, James J., Cepeda, Carlos, Lam, Hoa A., Bhatnagar, Anushree, Meloni, Edward G., Wu, Nanping, Ackerson, Larry C., Klapstein, Gloria J., Gajendiran, Mahadevan, Roth, Bryan L., Chesselet, Marie-Françoise, Maidment, Nigel T., Levine, Michael S., Shen, Jie
Published in The Journal of biological chemistry (31.10.2003)
Published in The Journal of biological chemistry (31.10.2003)
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Journal Article
A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
Fleming, Sheila M., Mulligan, Caitlin K., Richter, Franziska, Mortazavi, Farzad, Lemesre, Vincent, Frias, Carmen, Zhu, Chunni, Stewart, Alistair, Gozes, Illana, Morimoto, Bruce, Chesselet, Marie-Françoise
Published in Molecular and cellular neuroscience (01.03.2011)
Published in Molecular and cellular neuroscience (01.03.2011)
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Journal Article
CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
Schallert, Timothy, Fleming, Sheila M, Leasure, J.Leigh, Tillerson, Jennifer L, Bland, Sondra T
Published in Neuropharmacology (01.04.2000)
Published in Neuropharmacology (01.04.2000)
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Journal Article
Cranial and related sensorimotor impairments in rodent models of Parkinson's disease
Fleming, Sheila M., Schallert, Tim, Ciucci, Michelle R.
Published in Behavioural brain research (01.06.2012)
Published in Behavioural brain research (01.06.2012)
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Journal Article
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons
Richter, Franziska, Gao, Fuying, Medvedeva, Vera, Lee, Patrick, Bove, Nicholas, Fleming, Sheila M, Michaud, Magali, Lemesre, Vincent, Patassini, Stefano, De La Rosa, Krystal, Mulligan, Caitlin K, Sioshansi, Pedrom C, Zhu, Chunni, Coppola, Giovanni, Bordet, Thierry, Pruss, Rebecca M, Chesselet, Marie-Françoise
Published in Neurobiology of disease (01.09.2014)
Published in Neurobiology of disease (01.09.2014)
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Journal Article
Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins
Page, Lesley J, Suk, Ji Young, Bazhenova, Lyudmila, Fleming, Sheila M, Wood, Malcolm, Jiang, Yun, Guo, Ling T, Mizisin, Andrew P, Kisilevsky, Robert, Shelton, G. Diane, Balch, William E, Kelly, Jeffery W
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
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