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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Bagal, Sharan K, Omoto, Kiyoyuki, Blakemore, David C, Bungay, Peter J, Bilsland, James G, Clarke, Philip J, Corbett, Matthew S, Cronin, Ciaran N, Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J, Warmus, Joseph S
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker
Pike, Andy, Flanagan, Neil J., Storer, R. Ian, Swain, Nigel A., Tseng, Elaine
Published in Biopharmaceutics & drug disposition (01.09.2018)
Published in Biopharmaceutics & drug disposition (01.09.2018)
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The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker
Pike, Andy, Flanagan, Neil J., Storer, R. Ian, Swain, Nigel A., Tseng, Elaine
Published in Biopharmaceutics & drug disposition (01.09.2018)
Published in Biopharmaceutics & drug disposition (01.09.2018)
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Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)
Owen, Robert M, Blakemore, David, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A, Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C, Reynolds, David S, Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Design and identification of a novel, functionally subtype selective GABA A positive allosteric modulator (PF-06372865)
Owen, Robert M., Blakemore, David C, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah, Omoto, Kiyoyuki, Owen, Dafydd R, Pike, Andrew, Pryde, David C., Reynolds, David, Roeloffs, Rosemarie, Rose, Colin R., Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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GPR35 효능제 화합물
SWAIN NIGEL ALAN, FLANAGAN NEIL JOHN, WHITEHURST BENJAMIN, CONGREVE MILES STUART, BROWN GILES ALBERT
Year of Publication 29.12.2023
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Year of Publication 29.12.2023
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Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels
Jones, Hannah M., Butt, Richard P., Webster, Rob W., Gurrell, Ian, Dzygiel, Pawel, Flanagan, Neil, Fraier, Daniela, Hay, Tanya, Iavarone, Laura Else, Luckwell, Jacquelynn, Pearce, Hannah, Phipps, Alex, Segelbacher, Jill, Speed, Bill, Beaumont, Kevin
Published in Clinical pharmacokinetics (01.07.2016)
Published in Clinical pharmacokinetics (01.07.2016)
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The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Nav 1.7 channel blocker
Pike, Andy, Flanagan, Neil J, Storer, R Ian, Swain, Nigel A, Tseng, Elaine
Published in Biopharmaceutics & drug disposition (01.09.2018)
Published in Biopharmaceutics & drug disposition (01.09.2018)
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Highly potent and selective Na(V)1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Bagal, Sharan K., Omoto, Kiyoyuki, Blakemore, David C., Bungay, Peter J., Bilsland, James G., Clarke, Philip J., Corbett, Matthew S., Cronin, Ciaran N., Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J., Greasley, Samantha E., Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L., McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J., Warmus, Joseph S.
Published in Journal of medicinal chemistry (19.04.2018)
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Published in Journal of medicinal chemistry (19.04.2018)
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Highly potent and selective Na V 1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R Ian, Pike, Andy, Swain, Nigel A, Alexandrou, Aristos J, Bechle, Bruce M, Blakemore, David C, Brown, Alan D, Castle, Neil A, Corbett, Matthew S, Flanagan, Neil J, Fengas, David, Johnson, M Scott, Jones, Lyn H, Marron, Brian E, Payne, C Elizabeth, Printzenhoff, David, Rawson, David J, Rose, Colin R, Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W, Torella, Rubben, Tseng, Elaine, Warmus, Joseph S
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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GPR35 AGONIST COMPOUNDS
FLANAGAN, Neil John, BROWN, Giles Albert, CONGREVE, Miles Stuart, WHITEHURST, Benjamin, SWAIN, Nigel Alan
Year of Publication 15.05.2025
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Year of Publication 15.05.2025
Patent
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GPR35 AGONIST COMPOUNDS
FLANAGAN, Neil John, BROWN, Giles Albert, CONGREVE, Miles Stuart, WHITEHURST, Benjamin, SWAIN, Nigel Alan
Year of Publication 28.02.2024
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Year of Publication 28.02.2024
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GPR35 AGONIST COMPOUNDS
FLANAGAN, Neil John, BROWN, Giles Albert, CONGREVE, Miles Stuart, WHITEHURST, Benjamin, SWAIN, Nigel Alan
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
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GPR35 AGONIST COMPOUNDS
WHITEHURST, BENJAMIN, FLANAGAN, NEIL JOHN, BROWN, GILES ALBERT, CONGREVE, MILES STUART, SWAIN, NIGEL ALAN
Year of Publication 27.10.2022
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Year of Publication 27.10.2022
Patent