Genome‐wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci
Earley, Eric Jay, Kelly, Shannon, Fang, Fang, Alencar, Cecília Salete, Rodrigues, Daniela de Oliveira Werneck, Soares Cruz, Dahra Teles, Flanagan, Jonathan M., Ware, Russell E., Zhang, Xu, Gordeuk, Victor, Gladwin, Mark, Zhang, Yingze, Nouraie, Mehdi, Nekhai, Sergei, Sabino, Ester, Custer, Brian, Dinardo, Carla, Page, Grier P.
Published in British journal of haematology (01.04.2023)
Published in British journal of haematology (01.04.2023)
Get full text
Journal Article
Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips
Mathur, Tanmay, Singh, Kanwar Abhay, Pandian, Navaneeth K, Tsai, Shu-Huai, Hein, Travis W, Gaharwar, Akhilesh K, Flanagan, Jonathan M, Jain, Abhishek
Published in Lab on a chip (23.07.2019)
Published in Lab on a chip (23.07.2019)
Get full text
Journal Article
Tripartite collaboration of blood‐derived endothelial cells, next generation RNA sequencing and bioengineered vessel‐chip may distinguish vasculopathy and thrombosis among sickle cell disease patients
Mathur, Tanmay, Flanagan, Jonathan M., Jain, Abhishek
Published in Bioengineering & translational medicine (01.09.2021)
Published in Bioengineering & translational medicine (01.09.2021)
Get full text
Journal Article
Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity
Bouchier-Hayes, Lisa, Oberst, Andrew, McStay, Gavin P., Connell, Samuel, Tait, Stephen W.G., Dillon, Christopher P., Flanagan, Jonathan M., Beere, Helen M., Green, Douglas R.
Published in Molecular cell (24.09.2009)
Published in Molecular cell (24.09.2009)
Get full text
Journal Article
Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia
Chou, Stella T., Flanagan, Jonathan M., Vege, Sunitha, Luban, Naomi L.C., Brown, R. Clark, Ware, Russell E., Westhoff, Connie M.
Published in Blood advances (08.08.2017)
Published in Blood advances (08.08.2017)
Get full text
Journal Article
Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia
Schaefer, Beverly A, Flanagan, Jonathan M, Alvarez, Ofelia A, Nelson, Stephen C, Aygun, Banu, Nottage, Kerri A, George, Alex, Roberts, Carla W, Piccone, Connie M, Howard, Thad A, Davis, Barry R, Ware, Russell E
Published in PloS one (06.10.2016)
Published in PloS one (06.10.2016)
Get full text
Journal Article
Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia
Sheehan, Vivien A, Crosby, Jacy R, Sabo, Aniko, Mortier, Nicole A, Howard, Thad A, Muzny, Donna M, Dugan-Perez, Shannon, Aygun, Banu, Nottage, Kerri A, Boerwinkle, Eric, Gibbs, Richard A, Ware, Russell E, Flanagan, Jonathan M
Published in PloS one (31.10.2014)
Published in PloS one (31.10.2014)
Get full text
Journal Article
The fatty acid amide hydrolase 385 A/A (P129T) variant : haplotype analysis of an ancient missense mutation and validation of risk for drug addiction
FLANAGAN, Jonathan M, GERBER, Alexandra L, LUD CADET, Jean, BEUTLER, Ernest, SIPE, Jack C
Published in Human genetics (01.11.2006)
Published in Human genetics (01.11.2006)
Get full text
Journal Article
GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload
Puri, Latika, Flanagan, Jonathan M, Kang, Guolian, Ding, Juan, Bi, Wenjian, McCarville, Beth M, Loeffler, Ralf B, Tipirneni-Sajja, Aaryani, Villavicencio, Martha, Crews, Kristine R, Hillenbrand, Claudia M, Hankins, Jane S
Published in Journal of clinical medicine (05.11.2019)
Published in Journal of clinical medicine (05.11.2019)
Get full text
Journal Article
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions
Salgar, Suruchi, Bolívar, Beatriz E, Flanagan, Jonathan M, Anum, Shaniqua J, Bouchier-Hayes, Lisa
Published in Translational research : the journal of laboratory and clinical medicine (01.02.2023)
Published in Translational research : the journal of laboratory and clinical medicine (01.02.2023)
Get full text
Journal Article
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death
Bolívar, Beatriz E, Brown-Suedel, Alexandra N, Rohrman, Brittany A, Charendoff, Chloé I, Yazdani, Vanda, Belcher, John D, Vercellotti, Gregory M, Flanagan, Jonathan M, Bouchier-Hayes, Lisa
Published in The Journal of immunology (1950) (15.04.2021)
Published in The Journal of immunology (1950) (15.04.2021)
Get full text
Journal Article
Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
Ware, Russell E., Despotovic, Jenny M., Mortier, Nicole A., Flanagan, Jonathan M., He, Jin, Smeltzer, Matthew P., Kimble, Amy C., Aygun, Banu, Wu, Song, Howard, Thad, Sparreboom, Alex
Published in Blood (03.11.2011)
Published in Blood (03.11.2011)
Get full text
Journal Article
Genetic predictors for stroke in children with sickle cell anemia
Flanagan, Jonathan M., Frohlich, Denise M., Howard, Thad A., Schultz, William H., Driscoll, Catherine, Nagasubramanian, Ramamoorthy, Mortier, Nicole A., Kimble, Amy C., Aygun, Banu, Adams, Robert J., Helms, Ronald W., Ware, Russell E.
Published in Blood (16.06.2011)
Published in Blood (16.06.2011)
Get full text
Journal Article
Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes
Sheehan, Vivien A., Luo, Zhaoyu, Flanagan, Jonathan M., Howard, Thad A., Thompson, Bruce W., Wang, Winfred C., Kutlar, Abdullah, Ware, Russell E.
Published in American journal of hematology (01.07.2013)
Published in American journal of hematology (01.07.2013)
Get full text
Journal Article
Genetic variants in toll‐like receptor 4 are associated with lack of steroid‐responsiveness in pediatric ITP patients
Kim, Taylor Olmsted, Flanagan, Jonathan M., Habibi, Ali, Arulselvan, Abinaya, Lambert, Michele P., Grace, Rachael F., Despotovic, Jenny M.
Published in American journal of hematology (01.04.2020)
Published in American journal of hematology (01.04.2020)
Get full text
Journal Article
Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia
Flanagan, Jonathan M., Sheehan, Vivien, Linder, Heidi, Howard, Thad A., Wang, Yong-Dong, Hoppe, Carolyn C., Aygun, Banu, Adams, Robert J., Neale, Geoffrey A., Ware, Russell E.
Published in Blood (18.04.2013)
Published in Blood (18.04.2013)
Get full text
Journal Article
The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil
Friedrisch, João Ricardo, Sheehan, Vivien, Flanagan, Jonathan M., Baldan, Alessandro, Summarell, Carly C. Ginter, Bittar, Christina Matzembacher, Friedrisch, Bruno Kras, Wilke, Ianaê Indiara, Ribeiro, Camila Blos, Daudt, Liane Esteves, da Rocha Silla, Lucia Mariano
Published in Blood cells, molecules, & diseases (01.11.2016)
Published in Blood cells, molecules, & diseases (01.11.2016)
Get full text
Journal Article
Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia
Sakthivel, Dharaniya, Brown-Suedel, Alexandra N., Lopez, Karla E., Salgar, Suruchi, Coutinho, Luiza E., Keane, Francesca, Huang, Shixia, Sherry, Kenneth Mc, Charendoff, Chloé I., Dunne, Kevin P., Robichaux, Dexter J., Vargas-Hernández, Alexander, Le, BaoChau, Shin, Crystal S., Carisey, Alexandre F., Poreba, Marcin, Flanagan, Jonathan M., Bouchier-Hayes, Lisa
Published in Science advances (02.08.2024)
Published in Science advances (02.08.2024)
Get full text
Journal Article
A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data
Chang, Ti-Cheng, Haupfear, Kelly M., Yu, Jing, Rampersaud, Evadnie, Sheehan, Vivien A., Flanagan, Jonathan M., Hankins, Jane S., Weiss, Mitchell J., Wu, Gang, Vege, Sunitha, Westhoff, Connie M., Chou, Stella T., Zheng, Yan
Published in Blood advances (22.09.2020)
Published in Blood advances (22.09.2020)
Get full text
Journal Article
Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: Results from the BABY-HUG phase III clinical trial
McGann, Patrick T., Flanagan, Jonathan M., Howard, Thad A., Dertinger, Stephen D., He, Jin, Kulharya, Anita S., Thompson, Bruce W., Ware, Russell E.
Published in Pediatric blood & cancer (01.08.2012)
Published in Pediatric blood & cancer (01.08.2012)
Get full text
Journal Article