Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells
Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth
Published in Stem cell reports (12.05.2015)
Published in Stem cell reports (12.05.2015)
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BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination
Parker, Christopher, Chambers, Adam C., Flanagan, Dustin J., Ho, Jasmine Wing Yu, Collard, Tracey J., Ngo, Greg, Baird, Duncan M., Timms, Penny, Morgan, Rhys G., Sansom, Owen J., Williams, Ann C.
Published in DNA repair (01.07.2022)
Published in DNA repair (01.07.2022)
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Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo
Flanagan, Dustin J, Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J, Vincan, Elizabeth
Published in Disease models & mechanisms (01.08.2017)
Published in Disease models & mechanisms (01.08.2017)
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Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion
Flanagan, Dustin J, Schwab, Renate H M, Tran, Bang M, Phesse, Toby J, Vincan, Elizabeth
Published in Methods in molecular biology (Clifton, N.J.) (2019)
Published in Methods in molecular biology (Clifton, N.J.) (2019)
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PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
SAKTHIANANDESWAREN, Anuratha, CHRISTIE, Michael, RAMSAY, Robert G, PHESSE, Toby J, ERNST, Matthias, JEFFERY, Rosemary E, POULSOM, Richard, LEEDHAM, Simon J, SEGDITSAS, Stefania, TOMLINSON, Ian P. M, BERNHARD, Oliver K, SIMPSON, Richard J, D'ANDRETI, Carla, WALKER, Francesca, FAUX, Maree C, CHURCH, Nicole, CATIMEL, Bruno, FLANAGAN, Dustin J, VINCAN, Elizabeth, SIEBER, Oliver M, TSUI, Cary, JORISSEN, Robert N, SHAN LI, FLEMING, Nicholas I, GIBBS, Peter, LIPTON, Lara, MALATERRE, Jordane
Published in Cancer research (Chicago, Ill.) (15.05.2011)
Published in Cancer research (Chicago, Ill.) (15.05.2011)
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Journal Article
Wnt Signaling in Cancer: Not a Binary ON:OFF Switch
Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J
Published in Cancer research (Chicago, Ill.) (01.12.2019)
Published in Cancer research (Chicago, Ill.) (01.12.2019)
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Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
Holt, Amy K, Najumudeen, Arafath K, Collard, Tracey J, Li, Hao, Millett, Laura M, Hoskin, Ashley J, Legge, Danny N, Mortensson, Eleanor M H, Flanagan, Dustin J, Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D, Cronin, James, Sansom, Owen J, Williams, Ann C, Vincent, Emma E
Published in Cancer & metabolism (19.10.2023)
Published in Cancer & metabolism (19.10.2023)
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Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers
Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J
Published in British journal of pharmacology (01.12.2017)
Published in British journal of pharmacology (01.12.2017)
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Journal Article
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Flanagan, Dustin J, Barker, Nick, Costanzo, Natasha S Di, Mason, Elizabeth A, Gurney, Austin, Meniel, Valerie S, Koushyar, Sarah, Austin, Chloe R, Ernst, Matthias, Pearson, Helen B, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J, Vincan, Elizabeth
Published in Cancer research (Chicago, Ill.) (01.03.2019)
Published in Cancer research (Chicago, Ill.) (01.03.2019)
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Journal Article
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Published in Cell stem cell (04.08.2022)
Published in Cell stem cell (04.08.2022)
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Journal Article
Wnt Signalling in Gastrointestinal Epithelial Stem Cells
Flanagan, Dustin J, Austin, Chloe R, Vincan, Elizabeth, Phesse, Toby J
Published in Genes (23.03.2018)
Published in Genes (23.03.2018)
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Journal Article
Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I. J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J. A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Published in Nature (London) (21.07.2022)
Published in Nature (London) (21.07.2022)
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MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
Knight, John R P, Alexandrou, Constantinos, Skalka, George L, Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M, May-Wilson, Sebastian, Smith, Ewan M, Najumudeen, Arafath K, Gilroy, Kathryn, Ridgway, Rachel A, Flanagan, Dustin J, Smith, Rachael C L, McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D, Jackstadt, Rene, Waldron, Joseph A, Campbell, Andrew D, Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M, Sonenberg, Nahum, Proud, Christopher G, Jones, Neil P, Swarbrick, Martin E, McKinnon, Heather J, Faller, William J, Le Quesne, John, Edwards, Joanne, Willis, Anne E, Bushell, Martin, Sansom, Owen J
Published in Cancer discovery (01.05.2021)
Published in Cancer discovery (01.05.2021)
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Assessment of hepatitis B virus infection and interhost cellular responses using intrahepatic cholangiocyte organoids
Lim, Chuan K., Romeo, Ornella, Tran, Bang M., Flanagan, Dustin J., Kirby, Emily N., McCartney, Erin M., Tse, Edmund, Vincan, Elizabeth, Beard, Michael R.
Published in Journal of medical virology (01.11.2023)
Published in Journal of medical virology (01.11.2023)
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Journal Article
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Published in Cell stem cell (03.11.2022)
Published in Cell stem cell (03.11.2022)
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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration
Phesse, Toby J, Buchert, Michael, Stuart, Emma, Flanagan, Dustin J, Faux, Maree, Afshar-Sterle, Shoukat, Walker, Francesca, Zhang, Hui-Hua, Nowell, Cameron J, Jorissen, Robert, Tan, Chin Wee, Hirokawa, Yumiko, Eissmann, Moritz F, Poh, Ashleigh R, Malaterre, Jordane, Pearson, Helen B, Kirsch, David G, Provero, Paolo, Poli, Valeria, Ramsay, Robert G, Sieber, Oliver, Burgess, Antony W, Huszar, Dennis, Vincan, Elizabeth, Ernst, Matthias
Published in Science signaling (30.09.2014)
Published in Science signaling (30.09.2014)
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.
Published in Nature communications (31.01.2023)
Published in Nature communications (31.01.2023)
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