Search Results - "Flachner, Beáta" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo

by Stern, Noa, Gacs, Alexandra, Tátrai, Enikő, Flachner, Beáta, Hajdú, István, Dobi, Krisztina, Bágyi, István, Dormán, György, Lőrincz, Zsolt, Cseh, Sándor, Kígyós, Attila, Tóvári, József, Goldblum, Amiram
Published in International journal of molecular sciences (01.11.2022)

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Rapid Identification of Potential Drug Candidates from Multi-Million Compounds' Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening

Rapid Identification of Potential Drug Candidates from Multi-Million Compounds' Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening

by Szilágyi, Katalin, Flachner, Beáta, Hajdú, István, Szaszkó, Mária, Dobi, Krisztina, Lőrincz, Zsolt, Cseh, Sándor, Dormán, György
Published in Molecules (Basel, Switzerland) (15.09.2021)

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Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches

Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches

by Szilágyi, Katalin, Hajdú, István, Flachner, Beáta, Lőrincz, Zsolt, Balczer, Júlia, Gál, Péter, Závodszky, Péter, Pirli, Chiara, Balogh, Balázs, Mándity, István M, Cseh, Sándor, Dormán, György
Published in Molecules (Basel, Switzerland) (09.10.2019)

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A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts

A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts

by Somogyi, Márk, Szimler, Tamás, Baksa, Attila, Végh, Barbara M, Bakos, Tamás, Paréj, Katalin, Ádám, Csaba, Zsigmond, Áron, Megyeri, Márton, Flachner, Beáta, Sajó, Ráchel, Gráczer, Éva, Závodszky, Péter, Hajdú, István, Beinrohr, László
Published in PloS one (30.12.2019)

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Robust Recombinant Expression of Human Placental Ribonuclease Inhibitor in Insect Cells

Robust Recombinant Expression of Human Placental Ribonuclease Inhibitor in Insect Cells

by Flachner, Beáta, Dobi, Krisztina, Benedek, Anett, Cseh, Sándor, Lőrincz, Zsolt, Hajdú, István
Published in Biomolecules (Basel, Switzerland) (08.02.2022)

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Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments

Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments

by Kelemen, Ádám A, Kiss, Róbert, Ferenczy, György G, Kovács, László, Flachner, Beáta, Lőrincz, Zsolt, Keserű, György M
Published in Journal of chemical information and modeling (22.02.2016)

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RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System

RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System

by Meinzinger, Anne, Zsigmond, Áron, Horváth, Péter, Kellenberger, Alexandra, Paréj, Katalin, Tallone, Tiziano, Flachner, Beáta, Cserhalmi, Marcell, Lőrincz, Zsolt, Cseh, Sándor, Shmerling, Doron
Published in International journal of cell biology (31.10.2023)

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Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening

Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening

by Szaszkó, Mária, Hajdú, István, Flachner, Beáta, Dobi, Krisztina, Magyar, Csaba, Simon, István, Lőrincz, Zsolt, Kapui, Zoltán, Pázmány, Tamás, Cseh, Sándor, Dormán, György
Published in Molecular diversity (01.02.2017)

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Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors

Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors

by Dobi, Krisztina, Hajdú, István, Flachner, Beáta, Fabó, Gabriella, Szaszkó, Mária, Bognár, Melinda, Magyar, Csaba, Simon, István, Szisz, Dániel, Lőrincz, Zsolt, Cseh, Sándor, Dormán, György
Published in Molecules (Basel, Switzerland) (28.05.2014)

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A chemocentric approach to the identification of cancer targets

A chemocentric approach to the identification of cancer targets

by Flachner, Beáta, Lörincz, Zsolt, Carotti, Angelo, Nicolotti, Orazio, Kuchipudi, Praveena, Remez, Nikita, Sanz, Ferran, Tóvári, József, Szabó, Miklós J, Bertók, Béla, Cseh, Sándor, Mestres, Jordi, Dormán, György
Published in PloS one (25.04.2012)

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Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase

Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase

by Varga, Andrea, Szabó, Judit, Flachner, Beáta, Gugolya, Zoltán, Vonderviszt, Ferenc, Závodszky, Péter, Vas, Mária
Published in FEBS letters (19.11.2009)

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Communication between the Nucleotide Site and the Main Molecular Hinge of 3-Phosphoglycerate Kinase

Communication between the Nucleotide Site and the Main Molecular Hinge of 3-Phosphoglycerate Kinase

by Szabó, Judit, Varga, Andrea, Flachner, Beáta, Konarev, Peter V, Svergun, Dmitri I, Závodszky, Péter, Vas, Mária
Published in Biochemistry (Easton) (01.07.2008)

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Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase

Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase

by Varga, Andrea, Flachner, Beáta, Konarev, Peter, Gráczer, Éva, Szabó, Judit, Svergun, Dmitri, Závodszky, Péter, Vas, Mária
Published in FEBS letters (15.05.2006)

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Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3‐phosphoglycerate kinase

Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3‐phosphoglycerate kinase

by Varga, Andrea, Flachner, Beáta, Gráczer, Éva, Osváth, Szabolcs, Szilágyi, Andrea N., Vas, Mária
Published in The FEBS journal (01.04.2005)

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Substrate-Assisted Movement of the Catalytic Lys 215 during Domain Closure: Site-Directed Mutagenesis Studies of Human 3-Phosphoglycerate Kinase

Substrate-Assisted Movement of the Catalytic Lys 215 during Domain Closure: Site-Directed Mutagenesis Studies of Human 3-Phosphoglycerate Kinase

by Flachner, Beáta, Varga, Andrea, Szabó, Judit, Barna, László, Hajdú, István, Gyimesi, Gergely, Závodszky, Péter, Vas, Mária
Published in Biochemistry (Easton) (27.12.2005)

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Nucleotide Binding to Pig Muscle 3-Phosphoglycerate Kinase in the Crystal and in Solution: Relationship between Substrate Antagonism and Interdomain Communication

Nucleotide Binding to Pig Muscle 3-Phosphoglycerate Kinase in the Crystal and in Solution: Relationship between Substrate Antagonism and Interdomain Communication

by Merli, Angelo, Szilágyi, Andrea N, Flachner, Beáta, Rossi, Gian Luigi, Vas, Mária
Published in Biochemistry (Easton) (08.01.2002)

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Monoclonal antibody proteomics: Use of antibody mimotope displaying phages and the relevant synthetic peptides for mAb scouting

Monoclonal antibody proteomics: Use of antibody mimotope displaying phages and the relevant synthetic peptides for mAb scouting

by Hajdú, István, Flachner, Beáta, Bognár, Melinda, Végh, Barbara M, Dobi, Krisztina, Lőrincz, Zsolt, Lázár, József, Cseh, Sándor, Takács, László, Kurucz, István
Published in Immunology letters (01.08.2014)

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Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories

Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories

by Dobi, Krisztina, Flachner, Beáta, Pukáncsik, Mária, Máthé, Enikő, Bognár, Melinda, Szaszkó, Mária, Magyar, Csaba, Hajdú, István, Lőrincz, Zsolt, Simon, István, Fülöp, Ferenc, Cseh, Sándor, Dormán, György
Published in Chemical biology & drug design (01.10.2015)

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Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation

Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation

by Flachner, Beáta, Tömöri, Tünde, Hajdú, István, Dobi, Krisztina, Lőrincz, Zsolt, Cseh, Sándor, Dormán, György
Published in Medicinal chemistry research (01.03.2014)

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Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase

Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase

by Szabó, Judit, Varga, Andrea, Flachner, Beáta, Konarev, Peter V., Svergun, Dmitri I., Závodszky, Péter, Vas, Mária
Published in FEBS letters (16.04.2008)

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