PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.
Published in Cell (10.10.2013)
Published in Cell (10.10.2013)
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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
Lewis, Caroline A., Parker, Seth J., Fiske, Brian P., McCloskey, Douglas, Gui, Dan Y., Green, Courtney R., Vokes, Natalie I., Feist, Adam M., Vander Heiden, Matthew G., Metallo, Christian M.
Published in Molecular cell (17.07.2014)
Published in Molecular cell (17.07.2014)
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Lack of Evidence for PKM2 Protein Kinase Activity
Hosios, Aaron M., Fiske, Brian P., Gui, Dan Y., Vander Heiden, Matthew G.
Published in Molecular cell (03.09.2015)
Published in Molecular cell (03.09.2015)
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Increased PHGDH expression promotes aberrant melanin accumulation
Mattaini, Katherine R, Sullivan, Mark R, Lau, Allison N, Fiske, Brian P, Bronson, Roderick T, Vander Heiden, Matthew G
Published in BMC cancer (22.07.2019)
Published in BMC cancer (22.07.2019)
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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard L., Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Vander Heiden, Matthew G., Sabatini, David M.
Published in Nature (London) (16.04.2015)
Published in Nature (London) (16.04.2015)
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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M
Published in Nature chemical biology (01.06.2016)
Published in Nature chemical biology (01.06.2016)
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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Mayers, Jared R, Wu, Chen, Clish, Clary B, Kraft, Peter, Torrence, Margaret E, Fiske, Brian P, Yuan, Chen, Bao, Ying, Townsend, Mary K, Tworoger, Shelley S, Davidson, Shawn M, Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L, Ogino, Shuji, Stampfer, Meir J, Giovannucci, Edward L, Qian, Zhi Rong, Rubinson, Douglas A, Ma, Jing, Sesso, Howard D, Gaziano, John M, Cochrane, Barbara B, Liu, Simin, Wactawski-Wende, Jean, Manson, JoAnn E, Pollak, Michael N, Kimmelman, Alec C, Souza, Amanda, Pierce, Kerry, Wang, Thomas J, Gerszten, Robert E, Fuchs, Charles S, Vander Heiden, Matthew G, Wolpin, Brian M
Published in Nature medicine (01.10.2014)
Published in Nature medicine (01.10.2014)
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Journal Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G
Published in Nature chemical biology (01.10.2012)
Published in Nature chemical biology (01.10.2012)
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MYTX-011: A pH-Dependent Anti-c-MET Antibody-Drug Conjugate Designed for Enhanced Payload Delivery to c-MET-Expressing Tumor Cells
Gera, Nimish, Fitzgerald, Kyle M, Ramesh, Vijay, Patel, Purvi, Kanojia, Deepak, Colombo, Federico, Kien, Lena, Aoyama, Simon, Xu, Lihui, Jean, Jussekia, Deshpande, Amit M, Comb, William C, Chittenden, Thomas, Fiske, Brian P
Published in Molecular cancer therapeutics (04.09.2024)
Published in Molecular cancer therapeutics (04.09.2024)
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Journal Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G
Published in Nature chemical biology (26.08.2012)
Published in Nature chemical biology (26.08.2012)
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An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
Mattaini, Katherine R, Brignole, Edward J, Kini, Mitali, Davidson, Shawn M, Fiske, Brian P, Drennan, Catherine L, Vander Heiden, Matthew G
Published in Cancer & metabolism (29.04.2015)
Published in Cancer & metabolism (29.04.2015)
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Journal Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G
Published in Nature chemical biology (01.12.2012)
Published in Nature chemical biology (01.12.2012)
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Journal Article
MYTX-011: a pH-dependent anti-cMET antibody-drug conjugate designed for enhanced payload delivery to cMET expressing tumor cells
Gera, Nimish, Fitzgerald, Kyle M, Ramesh, Vijay, Patel, Purvi, Kanojia, Deepak, Colombo, Federico, Kien, Lena, Aoyama, Simon, Xu, Lihui, Jean, Jussekia, Deshpande, Amit M, Comb, William C, Chittenden, Thomas, Fiske, Brian P
Published in Molecular cancer therapeutics (30.04.2024)
Published in Molecular cancer therapeutics (30.04.2024)
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Journal Article
Abstract PR10: Serine biosynthesis from glucose regulates folate availability
Lewis, Caroline A., Fiske, Brian P., Pacold, Michael E., Hosios, Aaron M., Mattaini, Katherine R., Sabatini, David M., Heiden, Matthew G. Vander
Published in Molecular cancer research (01.01.2016)
Published in Molecular cancer research (01.01.2016)
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Journal Article
SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance
Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Published in Nature (London) (08.04.2015)
Published in Nature (London) (08.04.2015)
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