Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure
Meng, Wei, Pi, Zulan, Brigance, Robert, Rossi, Karen A, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia N, Wang, Tao, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure
Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David
Published in Circulation. Heart failure (01.03.2021)
Published in Circulation. Heart failure (01.03.2021)
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Journal Article
Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists
Tora, George, Jiang, Ji, Bostwick, Jeffrey S., Gargalovic, Peter S., Onorato, Joelle M., Luk, Chiuwa E., Generaux, Claudia, Xu, Carrie, Galella, Michael A., Wang, Tao, He, Yan, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
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Journal Article
Design and preparation of N-linked hydroxypyridine-based APJ agonists
Richter, Jeremy M., Alex Bates, J., Gargalovic, Peter, Onorato, Joelle M., Generaux, Claudia, Wang, Tao, Gordon, David A., Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Journal Article
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate
Johnson, James A, Kim, Soong-Hoon, Jiang, Ji, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia, He, Yan, Chen, Xue-Qing, Xu, Carrie, Galella, Michael A, Wang, Tao, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans
WEISKOPF, Richard B, FEINER, John, HOPF, Harriet, LIEBERMAN, Jeremy, FINLAY, Heather E, QUAH, Cheng, KRAMER, Joel H, BOSTROM, Alan, TOY, Pearl
Published in Anesthesiology (Philadelphia) (01.05.2006)
Published in Anesthesiology (Philadelphia) (01.05.2006)
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Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species
Chen, Xue-Qing, Ziemba, Theresa, Huang, Christine, Chang, Ming, Xu, Carrie, Qiao, Jennifer X., Wang, Tammy C., Finlay, Heather J., Salvati, Mark E., Adam, Leonard P., Gudmundsson, Olafur, Hageman, Michael J.
Published in Journal of pharmaceutical sciences (01.05.2018)
Published in Journal of pharmaceutical sciences (01.05.2018)
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Journal Article
Identification of 6‑Hydroxypyrimidin-4(1H)‑one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists
Pi, Zulan, Johnson, James A, Meng, Wei, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Generaux, Claudia N, Wang, Tao, He, Yan, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Journal Article
Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide
Gunaga, Prashantha, Lloyd, John, Mummadi, Somanadham, Banerjee, Abhisek, Dhondi, Naveen Kumar, Hennan, James, Subray, Veena, Jayaram, Ramya, Rajugowda, Nagendra, Umamaheshwar Reddy, Kommuri, Kumaraguru, Duraimurugan, Mandal, Umasankar, Beldona, Dasthagiri, Adisechen, Ashok Kumar, Yadav, Navnath, Warrier, Jayakumar, Johnson, James A, Sale, Harinath, Putlur, Siva Prasad, Saxena, Ajay, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, MaryLee, Xing, Dezhi, Gupta, Arun Kumar, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Levesque, Paul, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo
Tora, George, Kim, Soong-Hoon, Pi, Zulan, Johnson, James A, Jiang, Ji, Phillips, Monique, Lloyd, John, Abell, Lynn M, Lu, Hao, Locke, Gregory, Adam, Leonard P, Taylor, David S, Yin, Xiaohong, Behnia, Kamelia, Zhao, Lei, Yang, Richard, Basso, Michael, Caporuscio, Christian, Chen, Alice Ye, Liu, Eddie, Kirshgessner, Todd, Onorato, Joelle M, Ryan, Carol, Traeger, Sarah C, Gordon, David, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Journal Article
Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5‑[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide
Gunaga, Prashantha, Lloyd, John, Mummadi, Somanadham, Banerjee, Abhisek, Dhondi, Naveen Kumar, Hennan, James, Subray, Veena, Jayaram, Ramya, Rajugowda, Nagendra, Umamaheshwar Reddy, Kommuri, Kumaraguru, Duraimurugan, Mandal, Umasankar, Beldona, Dasthagiri, Adisechen, Ashok Kumar, Yadav, Navnath, Warrier, Jayakumar, Johnson, James A, Sale, Harinath, Putlur, Siva Prasad, Saxena, Ajay, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, MaryLee, Xing, Dezhi, Gupta, Arun Kumar, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Levesque, Paul, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Associations between exposure to advertising of foods high in fats, salt and sugar and purchase of energy and nutrients: a cross-sectional study
Finlay, Amy Heather, Jones, Andrew, Cummins, Steven, Yau, Amy, Cornelsen, Laura, Robinson, Eric, Boyland, Emma
Published in Public health nutrition (10.10.2024)
Published in Public health nutrition (10.10.2024)
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Journal Article
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents
Onorato, Joelle M., Xu, Carrie, Chen, Xue-Qing, Rose, Anne V., Generaux, Claudia, Lentz, Kimberley, Shipkova, Petia, Arthur, Susan, Hennan, James K., Haskell, Roy, Myers, Michael C., Lawrence, R. Michael, Finlay, Heather J., Basso, Michael, Bostwick, Jeffrey, Fernando, Gayani, Garcia, Ricardo, Hellings, Samuel, Hsu, Mei-Yin, Zhang, Rongan, Zhao, Lei, Gargalovic, Peter
Published in Analytical biochemistry (01.03.2019)
Published in Analytical biochemistry (01.03.2019)
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Journal Article
Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
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Journal Article
Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
Hu, Carol H., Wang, Tammy C., Qiao, Jennifer X., Haque, Lauren, Chen, Alice Y.A., Taylor, David S., Ying, Xiaohong, Onorato, Joelle M., Galella, Michael, Shen, Hong, Huang, Christine S., Toussaint, Nathalie, Li, Yi-Xin, Abell, Lynn, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Journal Article
Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)
Qiao, Jennifer X, Wang, Tammy C, Adam, Leonard P, Chen, Alice Ye A, Taylor, David S, Yang, Richard Z, Zhuang, Shaobin, Sleph, Paul G, Li, Julia P, Li, Danshi, Yin, Xiaohong, Chang, Ming, Chen, Xue-Qing, Shen, Hong, Li, Jianqing, Smith, Daniel, Wu, Dauh-Rurng, Leith, Leslie, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Miller, Michael M, Bilder, Donna, Rampulla, Richard, Li, Yi-Xin, Xu, Carrie, Lawrence, R. Michael, Poss, Michael A, Levesque, Paul, Gordon, David A, Huang, Christine S, Finlay, Heather J, Wexler, Ruth R, Salvati, Mark E
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Journal Article
Pseudosaccharin amines as potent and selective KV1.5 blockers
Lloyd, John, Finlay, Heather J., Kover, Alexander, Johnson, James, Pi, Zulan, Jiang, Ji, Neels, James, Cavallaro, Cullen, Wexler, Ruth, Conder, Mary Lee, Shi, Hong, Li, Danshi, Sun, Huabin, Chimalakonda, Anjaneya, Huang, Christine, Salvati, Mark, Levesque, Paul
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Journal Article
Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists
Lloyd, John, Finlay, Heather J, Atwal, Karnail, Kover, Alexander, Prol, Joseph, Yan, Lin, Bhandaru, Rao, Vaccaro, Wayne, Huynh, Tram, Huang, Christine S, Conder, Marylee, Jenkins-West, Tonya, Sun, Huabin, Li, Danshi, Levesque, Paul
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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