Mature chief cells are cryptic progenitors for metaplasia in the stomach
Nam, Ki Taek, Lee, Hyuk-Joon, Sousa, Josane F, Weis, Victoria G, O'Neal, Ryan L, Finke, Paul E, Romero-Gallo, Judith, Shi, Guanglu, Mills, Jason C, Peek, Jr, Richard M, Konieczny, Stephen F, Goldenring, James R
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2010)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2010)
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Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Finke, Paul E, Cascieri, Margaret A, Sadowski, Sharon, Ber, Elzbieta, Chicchi, Gary G, Kurtz, Marc, Metzger, Joseph, Eiermann, George, Tsou, Nancy N, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, MacIntyre, D. Euan
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression
Weis, Victoria G, Sousa, Josane F, LaFleur, Bonnie J, Nam, Ki Taek, Weis, Jared A, Finke, Paul E, Ameen, Nadia A, Fox, James G, Goldenring, James R
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Published in Gut (01.09.2013)
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives
Meurer, Laura C., Finke, Paul E., Owens, Karen A., Tsou, Nancy N., Ball, Richard G., Mills, Sander G., MacCoss, Malcolm, Sadowski, Sharon, Cascieri, Margaret A., Tsao, Kwei-Lan, Chicchi, Gary G., Egger, Linda A., Luell, Silvi, Metzger, Joseph M., MacIntyre, D. Euan, Rupniak, Nadia M.J., Williams, Angela R., Hargreaves, Richard J.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection
Kim, Dooseop, Wang, Liping, Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Carver, Gwen, Carella, Anthony, Holmes, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
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THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS
HUSKEY, Su-Er W, DEAN, Brian J, STRAUSS, John R, CUNNINGHAM, Paul K, FEENEY, William P, FRANKLIN, Ronald B, BAILLIE, Thomas A, CHIU, Shuet-Hing L, DOSS, George A, ZHEN WANG, HOP, Cornelis E. C. A, ANARI, Reza, FINKE, Paul E, ROBICHAUD, Albert J, MINGHUA ZHANG, WANG, Bonnie
Published in Drug metabolism and disposition (01.02.2004)
Published in Drug metabolism and disposition (01.02.2004)
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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5‑Selective Antagonists
Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F, Romero, F. Anthony, Finke, Paul E, Moningka, Remond, Bao, Jianming, Plotkin, Michael A, Shang, Jin, Dingley, Karen H, Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D, Ujjainwalla, Feroze, Wood, Harold B, Duffy, Joseph L
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Spasmolytic Polypeptide-Expressing Metaplasia (SPEM) Does Not Arise From LGR5-Expressing Cells in the Gastric Fundus
Nam, Ki Taek, O'Neal, Ryan L, Coffey, Robert J, Finke, Paul E, Barker, Nicholas, Goldenring, James R
Published in Gastroenterology (New York, N.Y. 1943) (2011)
Published in Gastroenterology (New York, N.Y. 1943) (2011)
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR
Finke, Paul E., Meurer, Laura C., Levorse, Dorothy A., Mills, Sander G., MacCoss, Malcolm, Sadowski, Sharon, Cascieri, Margaret A., Tsao, Kwei-Lan, Chicchi, Gary G., Metzger, Joseph M., MacIntyre, D. Euan
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Binding of 2-Aryl-4-(piperidin-1-yl)butanamines and 1,3,4-Trisubstituted Pyrrolidines to Human CCR5: A Molecular Modeling-Guided Mutagenesis Study of the Binding Pocket
Castonguay, Laurie A, Weng, Youmin, Adolfsen, William, Di Salvo, Jerry, Kilburn, Ruth, Caldwell, Charles G, Daugherty, Bruce L, Finke, Paul E, Hale, Jeffrey J, Lynch, Christopher L, Mills, Sander G, MacCoss, Malcolm, Springer, Martin S, DeMartino, Julie A
Published in Biochemistry (Easton) (18.02.2003)
Published in Biochemistry (Easton) (18.02.2003)
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Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists
Plummer, Christopher W., Finke, Paul E., Mills, Sander G., Wang, Junying, Tong, Xinchun, Doss, George A., Fong, Tung M., Lao, Julie Z., Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes
Finke, Paul E., Oates, Bryan, Mills, Sander G., MacCoss, Malcolm, Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Schleif, William A., Emini, Emilio A.
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
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Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists
Meurer, Laura C., Finke, Paul E., Mills, Sander G., Walsh, Thomas F., Toupence, Richard B., Goulet, Mark T., Wang, Junying, Tong, Xinchun, Fong, Tung M., Lao, Julie, Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Sloan Stribling, D., Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes
DORN, Conrad P, FINKE, Paul E, DEMARTINO, Julie A, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, OATES, Bryan, SCHLEIF, William A, EMINI, Emilio A, BUDHU, Richard J, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Journal Article
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents
SHEARMAN, Lauren P, SLOAN STRIBLING, D, SPANN, Stephanie K, MACNEIL, Douglas J, FONG, Tung M, METZGER, Joseph M, GOULET, Mark T, HAGMANN, William K, PLUMMER, Christopher W, FINKE, Paul E, MILLS, Sander G, SHAH, Shrenik K, CAMACHO, Ramon E, TRUONG, Quang, VAN DER PLOEG, L. H. T, EUAN MACINTYRE, D, STRACK, Alison M, ROSKO, Kimberly M, JUNYING WANG, TONG, Sharon, YUE FENG, MARSH, Donald J, HONG YU, XIAOMING GUAN
Published in European journal of pharmacology (28.01.2008)
Published in European journal of pharmacology (28.01.2008)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: Structure-activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes
FINKE, Paul E, MEURER, Laura C, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, SCHLEIF, William A, OATES, Bryan, EMINI, Emilio A, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L, DEMARTINO, Julie A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity
Hale, Jeffrey J., Budhu, Richard J., Holson, Edward B., Finke, Paul E., Oates, Bryan, Mills, Sander G., MacCoss, Malcolm, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Siciliano, Salvatore, Malkowitz, Lorraine, Schleif, William A., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Holmes, Karen, Lineberger, Janet, Carella, Anthony, Carver, Gwen, Emini, Emilio
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Journal Article
Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution
Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L
Published in Journal of medicinal chemistry (01.03.1993)
Published in Journal of medicinal chemistry (01.03.1993)
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