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Specificity, stability, and potency of monocyclic β-lactam inhibitors of human leucocyte elastase
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Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
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Mechanism of inhibition of human leucocyte elastase by monocyclic β-lactams
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An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung
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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol
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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes
Finke, Paul E., Oates, Bryan, Mills, Sander G., MacCoss, Malcolm, Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Schleif, William A., Emini, Emilio A.
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Mechanism of inhibition of human leukocyte elastase by monocyclic .beta.-lactams
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Published in Biochemistry (Easton) (31.08.1993)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: Structure-activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity
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Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection
Kim, Dooseop, Wang, Liping, Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Carver, Gwen, Carella, Anthony, Holmes, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: A proposed pharmacophore model for 1-[ N-(methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes
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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones
Finke, Paul E, Shah, Shrenik K, Fletcher, Daniel S, Ashe, Bonnie M, Brause, Karen A, Chandler, Gilbert O, Dellea, Pam S, Hand, Karen M, Maycock, Alan L
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Published in Journal of medicinal chemistry (01.06.1995)
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Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes
Underwood, D J, Green, B G, Chabin, R, Mills, S, Doherty, J B, Finke, P E, MacCoss, M, Shah, S K, Burgey, C S, Dickinson, T A
Published in Biochemistry (Easton) (07.11.1995)
Published in Biochemistry (Easton) (07.11.1995)
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