Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
Haider, Ahmed, Kretz, Julian, Gobbi, Luca, Ahmed, Hazem, Atz, Kenneth, Bürkler, Markus, Bartelmus, Christian, Fingerle, Jürgen, Guba, Wolfgang, Ullmer, Christoph, Honer, Michael, Knuesel, Irene, Weber, Markus, Brink, Andreas, Herde, Adrienne Müller, Keller, Claudia, Schibli, Roger, Mu, Linjing, Grether, Uwe, Ametamey, Simon M
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases
Nettekoven, Matthias, Adam, Jean-Michel, Bendels, Stefanie, Bissantz, Catarina, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Guba, Wolfgang, Kimbara, Atsushi, Ottaviani, Giorgio, Püllmann, Bernd, Rogers-Evans, Mark, Röver, Stephan, Rothenhäusler, Benno, Schmitt, Sebastien, Schuler, Franz, Schulz-Gasch, Tanja, Ullmer, Christoph
Published in ChemMedChem (19.01.2016)
Published in ChemMedChem (19.01.2016)
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Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016)
Nettekoven, Matthias, Adam, Jean-Michel, Bendels, Stefanie, Bissantz, Catarina, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Guba, Wolfgang, Kimbara, Atsushi, Ottaviani, Giorgio, Püllmann, Bernd, Rogers-Evans, Mark, Röver, Stephan, Rothenhäusler, Benno, Schmitt, Sebastien, Schuler, Franz, Schulz-Gasch, Tanja, Ullmer, Christoph
Published in ChemMedChem (01.01.2016)
Published in ChemMedChem (01.01.2016)
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Published in Nature communications (03.01.2017)
Published in Nature communications (03.01.2017)
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Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
Storti, Federica, Klee, Katrin, Todorova, Vyara, Steiner, Regula, Othman, Alaa, van der Velde-Visser, Saskia, Samardzija, Marijana, Meneau, Isabelle, Barben, Maya, Karademir, Duygu, Pauzuolyte, Valda, Boye, Sanford L, Blaser, Frank, Ullmer, Christoph, Dunaief, Joshua L, Hornemann, Thorsten, Rohrer, Lucia, den Hollander, Anneke, von Eckardstein, Arnold, Fingerle, Jürgen, Maugeais, Cyrille, Grimm, Christian
Published in eLife (13.03.2019)
Published in eLife (13.03.2019)
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Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor
Slavik, Roger, Grether, Uwe, Müller Herde, Adrienne, Gobbi, Luca, Fingerle, Jürgen, Ullmer, Christoph, Krämer, Stefanie D, Schibli, Roger, Mu, Linjing, Ametamey, Simon M
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010
Brennecke, Benjamin, Gazzi, Thais, Atz, Kenneth, Fingerle, Jürgen, Kuner, Pascal, Schindler, Torsten, Weck, Guy de, Nazaré, Marc, Grether, Uwe
Published in Pharmaceutical patent analyst (01.05.2021)
Published in Pharmaceutical patent analyst (01.05.2021)
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Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E M
Published in Molecules (Basel, Switzerland) (13.09.2019)
Published in Molecules (Basel, Switzerland) (13.09.2019)
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RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)
Published in Frontiers in pharmacology (12.07.2024)
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A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies
Chicca, Andrea, Bátora, Daniel, Ullmer, Christoph, Caruso, Antonello, Grüner, Sabine, Fingerle, Jürgen, Hartung, Thomas, Degen, Roland, Müller, Matthias, Grether, Uwe, Pacher, Pal, Gertsch, Jürg
Published in ACS pharmacology & translational science (09.08.2024)
Published in ACS pharmacology & translational science (09.08.2024)
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Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE―/― mice
BOT, Ilze, BOT, Martine, BIESSEN, Erik A. L, VAN HEININGEN, Sandra H, VAN SANTBRINK, Peter J, LANKHUIZEN, Inge M, HARTMAN, Peter, GRUENER, Sabine, HILPERT, Hans, VAN BERKEL, Theo J. C, FINGERLE, Jürgen
Published in Cardiovascular research (01.01.2011)
Published in Cardiovascular research (01.01.2011)
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T Lymphocytes Inhibit the Vascular Response to Injury
Hansson, Goran K., Holm, Jan, Holm, Susanna, Fotev, Zisi, Hedrich, Hans-Jurgen, Fingerle, Jurgen
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.1991)
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.1991)
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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Korn, Claudia, Sykes, David, Forn-Cuni, Gabriel, Pfaff, Patrick, Sarott, Roman C, Westphal, Matthias V, Mostinski, Yelena, Mach, Leonard, Wasinska-Kalwa, Malgorzata, Weise, Marie, Hoare, Bradley L, Milju, Tamara, Mexi, Maira, Roth, Nicolas, Koers, Eline J, Guba, Wolfgang, Alker, Andr, Rufer, Arne C, Kusznir, Eric A, Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A, Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Nettekoven, Matthias, Benito-Cuesta, Irene, Grande, Teresa, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Honer, Michael, Fingerle, Jürgen, Scheffel, Jörg, Broichhagen, Johannes, Gawrisch, Klaus, Romero, Julián, Hillard, Cecilia J, Varga, Zoltan V, van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, Ullmer, Christoph, McCormick, Peter J, Oddi, Sergio, Spaink, Herman P, Maccarrone, Mauro, Veprintsev, Dmitry B, Carreira, Erick M, Grether, Uwe, Nazaré, Marc
Published in Chemical science (Cambridge) (18.05.2022)
Published in Chemical science (Cambridge) (18.05.2022)
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Inhibition of NO Biosynthesis, but not Elevated Blood Pressure, Reduces Angiogenesis in Rat Models of Secondary Hypertension
Kiefer, Fabrice N., Misteli, Heidi, Kalak, Nabil, Tschudin, Karin, Fingerle, Jurgen, Kooij, Maaike Van Der, Stumm, Michael, Sumanovski, Lazar T., Sieber, Cornel C., Battegay, Edouard J.
Published in Blood pressure (2002)
Published in Blood pressure (2002)
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Regulation of smooth muscle cell growth in injured artery
Clowes, A W, Clowes, M M, Fingerle, J, Reidy, M A
Published in Journal of cardiovascular pharmacology (1989)
Published in Journal of cardiovascular pharmacology (1989)
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The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
Gretarsdottir, Solveig, Thorleifsson, Gudmar, Reynisdottir, Sigridur Th, Manolescu, Andrei, Jonsdottir, Sif, Jonsdottir, Thorbjörg, Gudmundsdottir, Thorunn, Bjarnadottir, Sigrun M, Einarsson, Olafur B, Gudjonsdottir, Herdis M, Hawkins, Malcolm, Gudmundsson, Gudmundur, Gudmundsdottir, Hrefna, Andrason, Hjalti, Gudmundsdottir, Asta S, Sigurdardottir, Matthildur, Chou, Thomas T, Nahmias, Joseph, Goss, Shyamali, Sveinbjörnsdottir, Sigurlaug, Valdimarsson, Einar M, Jakobsson, Finnbogi, Agnarsson, Uggi, Gudnason, Vilmundur, Thorgeirsson, Gudmundur, Fingerle, Jurgen, Gurney, Mark, Gudbjartsson, Daniel, Frigge, Michael L, Kong, Augustine, Stefansson, Kari, Gulcher, Jeffrey R
Published in Nature genetics (01.10.2003)
Published in Nature genetics (01.10.2003)
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Fast perfusion measurements in rat skeletal muscle at rest and during exercise with single-voxel FAIR (flow-sensitive alternating inversion recovery)
Pohmann, Rolf, Künnecke, Basil, Fingerle, Jürgen, Kienlin, Markus von
Published in Magnetic resonance in medicine (01.01.2006)
Published in Magnetic resonance in medicine (01.01.2006)
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New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopy
Giannesini, Benoit, Izquierdo, Marguerite, Le Fur, Yann, Cozzone, Patrick J., Fingerle, Jürgen, Himber, Jacques, Künnecke, Basil, Von Kienlin, Markus, Bendahan, David
Published in Magnetic resonance in medicine (01.11.2005)
Published in Magnetic resonance in medicine (01.11.2005)
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The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
Gretarsdottir, Solveig, Gulcher, Jeffrey R, Thorleifsson, Gudmar, Reynisdottir, Sigridur Th, Manolescu, Andrei, Jonsdottir, Sif, Jonsdottir, Thorbjörg, Gudmundsdottir, Thorunn, Bjarnadottir, Sigrun M, Einarsson, Olafur B, Gudjonsdottir, Herdis M, Hawkins, Malcolm, Gudmundsson, Gudmundur, Gudmundsdottir, Hrefna, Andrason, Hjalti, Gudmundsdottir, Asta S, Sigurdardottir, Matthildur, Chou, Thomas T, Nahmias, Joseph, Goss, Shyamali, Sveinbjörnsdottir, Sigurlaug, Valdimarsson, Einar M, Jakobsson, Finnbogi, Agnarsson, Uggi, Gudnason, Vilmundur, Thorgeirsson, Gudmundur, Fingerle, Jurgen, Gurney, Mark, Gudbjartsson, Daniel, Frigge, Michael L, Kong, Augustine, Stefansson, Kari
Published in Nature genetics (01.10.2003)
Published in Nature genetics (01.10.2003)
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NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS
Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, Rogers‐Evans, Mark, Rothenhäusler, Benno, Ullmer, Christoph, Fingerle, Jürgen, Grether, Uwe, Knuesel, Irene, Boeckers, Tobias M, Ludolph, Albert, Wirth, Thomas, Roselli, Francesco, Baumann, Bernd
Published in The EMBO journal (15.08.2018)
Published in The EMBO journal (15.08.2018)
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