Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily
Tsutakawa, Susan E., Classen, Scott, Chapados, Brian R., Arvai, Andrew S., Finger, L. David, Guenther, Grant, Tomlinson, Christopher G., Thompson, Peter, Sarker, Altaf H., Shen, Binghui, Cooper, Priscilla K., Grasby, Jane A., Tainer, John A.
Published in Cell (15.04.2011)
Published in Cell (15.04.2011)
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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
Tsutakawa, Susan E., Thompson, Mark J., Arvai, Andrew S., Neil, Alexander J., Shaw, Steven J., Algasaier, Sana I., Kim, Jane C., Finger, L. David, Jardine, Emma, Gotham, Victoria J.B., Sarker, Altaf H., Her, Mai Z., Rashid, Fahad, Hamdan, Samir M., Mirkin, Sergei M., Grasby, Jane A., Tainer, John A.
Published in Nature communications (27.06.2017)
Published in Nature communications (27.06.2017)
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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
Exell, Jack C, Thompson, Mark J, Finger, L David, Shaw, Steven J, Debreczeni, Judit, Ward, Thomas A, McWhirter, Claire, Siöberg, Catrine L B, Molina, Daniel Martinez, Abbott, W Mark, Jones, Clifford D, Nissink, J Willem M, Durant, Stephen T, Grasby, Jane A
Published in Nature chemical biology (01.10.2016)
Published in Nature chemical biology (01.10.2016)
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Journal Article
Observation of unpaired substrate DNA in the flap endonuclease-1 active site
Finger, L David, Patel, Nikesh, Beddows, Amanda, Ma, Long, Exell, Jack C, Jardine, Emma, Jones, Anita C, Grasby, Jane A
Published in Nucleic acids research (01.11.2013)
Published in Nucleic acids research (01.11.2013)
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Journal Article
Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1
Bennet, Ian A, Finger, L David, Baxter, Nicola J, Ambrose, Benjamin, Hounslow, Andrea M, Thompson, Mark J, Exell, Jack C, Shahari, Nur Nazihah B Md, Craggs, Timothy D, Waltho, Jonathan P, Grasby, Jane A
Published in Nucleic acids research (20.06.2018)
Published in Nucleic acids research (20.06.2018)
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Journal Article
The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis
Finger, L. David, Blanchard, M. Suzette, Theimer, Carla A., Sengerová, Blanka, Singh, Purnima, Chavez, Valerie, Liu, Fei, Grasby, Jane A., Shen, Binghui
Published in The Journal of biological chemistry (14.08.2009)
Published in The Journal of biological chemistry (14.08.2009)
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Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases
Shen, Binghui, Singh, Purnima, Liu, Ren, Qiu, Junzhuan, Zheng, Li, Finger, L. David, Alas, Steve
Published in BioEssays (01.07.2005)
Published in BioEssays (01.07.2005)
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The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome
Trego, Kelly S., Chernikova, Sophia B., Davalos, Albert R., Perry, J. Jefferson P., Finger, L. David, Ng, Cliff, Tsai, Miaw-Sheue, Yannone, Steven M., Tainer, John A., Campisi, Judith, Cooper, Priscilla K.
Published in Cell cycle (Georgetown, Tex.) (15.06.2011)
Published in Cell cycle (Georgetown, Tex.) (15.06.2011)
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Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates
Moré, Margret I., Finger, L. David, Stryker, Joel L., Fuqua, Clay, Eberhard, Anatol, Winans, Stephen C.
Published in Science (American Association for the Advancement of Science) (14.06.1996)
Published in Science (American Association for the Advancement of Science) (14.06.1996)
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Functional regulation of FEN1 nuclease and its link to cancer
Zheng, Li, Jia, Jia, Finger, L David, Guo, Zhigang, Zer, Cindy, Shen, Binghui
Published in Nucleic acids research (01.02.2011)
Published in Nucleic acids research (01.02.2011)
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Journal Article
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links
Morton, Sally B., Finger, L. David, van der Sluijs, Roxanne, Mulcrone, William D., Hodskinson, Michael, Millington, Christopher L., Vanhinsbergh, Christina, Patel, Ketan J., Dickman, Mark J., Knipscheer, Puck, Grasby, Jane A., Williams, David M.
Published in Journal of the American Chemical Society (18.01.2023)
Published in Journal of the American Chemical Society (18.01.2023)
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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction
Algasaier, Sana I., Exell, Jack C., Bennet, Ian A., Thompson, Mark J., Gotham, Victoria J.B., Shaw, Steven J., Craggs, Timothy D., Finger, L. David, Grasby, Jane A.
Published in The Journal of biological chemistry (08.04.2016)
Published in The Journal of biological chemistry (08.04.2016)
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Journal Article
Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing
Patel, Nikesh, Exell, Jack C., Jardine, Emma, Ombler, Ben, Finger, L. David, Ciani, Barbara, Grasby, Jane A.
Published in The Journal of biological chemistry (22.11.2013)
Published in The Journal of biological chemistry (22.11.2013)
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Journal Article
Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends
Patel, Nikesh, Atack, John M, Finger, L David, Exell, Jack C, Thompson, Peter, Tsutakawa, Susan, Tainer, John A, Williams, David M, Grasby, Jane A
Published in Nucleic acids research (01.05.2012)
Published in Nucleic acids research (01.05.2012)
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Journal Article
The wonders of flap endonucleases: structure, function, mechanism and regulation
Finger, L David, Atack, John M, Tsutakawa, Susan, Classen, Scott, Tainer, John, Grasby, Jane, Shen, Binghui
Published in Sub-cellular biochemistry (01.01.2012)
Published in Sub-cellular biochemistry (01.01.2012)
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Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases
Beddows, Amanda, Patel, Nikesh, Finger, L David, Atack, John M, Williams, David M, Grasby, Jane A
Published in Chemical communications (Cambridge, England) (14.09.2012)
Published in Chemical communications (Cambridge, England) (14.09.2012)
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