RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei
Published in Immunity (Cambridge, Mass.) (19.07.2016)
Published in Immunity (Cambridge, Mass.) (19.07.2016)
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Herpes Simplex Virus Suppresses Necroptosis in Human Cells
Guo, Hongyan, Omoto, Shinya, Harris, Philip A., Finger, Joshua N., Bertin, John, Gough, Peter J., Kaiser, William J., Mocarski, Edward S.
Published in Cell host & microbe (11.02.2015)
Published in Cell host & microbe (11.02.2015)
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Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity
Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.
Published in The Journal of biological chemistry (20.07.2012)
Published in The Journal of biological chemistry (20.07.2012)
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides
JELINSKY, Scott A, TURNER, Terry T, BANG, Hyun J, FINGER, Joshua N, SOLARZ, Mark K, WILSON, Ewa, BROWN, Eugene L, KOPF, Gregory S, JOHNSTON, Daniel S
Published in Biology of reproduction (01.04.2007)
Published in Biology of reproduction (01.04.2007)
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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Gene Expression During Development of Fetal and Adult Leydig Cells
DONG, LEI, JELINSKY, SCOTT A., FINGER, JOSHUA N., JOHNSTON, DANIEL S., KOPF, GREGORY S., SOTTAS, CHANTAL M., HARDY, MATTHEW P., GE, REN-SHAN
Published in Annals of the New York Academy of Sciences (01.12.2007)
Published in Annals of the New York Academy of Sciences (01.12.2007)
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
Harris, Philip A, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Finger, Joshua N, Hoffman, Sandra J, Kahler, Kirsten M, Lehr, Ruth, Lich, John D, Nagilla, Rakesh, Nolte, Robert T, Ouellette, Michael T, Pao, Christina S, Schaeffer, Michelle C, Smallwood, Angela, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Identification of Testis-Specific Male Contraceptive Targets
JOHNSTON, DANIEL S., JELINSKY, SCOTT A., ZHI, YU, FINGER, JOSHUA N., KOPF, GREGORY S., WRIGHT, WILLIAM W.
Published in Annals of the New York Academy of Sciences (01.12.2007)
Published in Annals of the New York Academy of Sciences (01.12.2007)
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Journal Article
The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides1
Jelinsky, Scott A, Turner, Terry T, Bang, Hyun J, Finger, Joshua N, Solarz, Mark K, Wilson, Ewa, Brown, Eugene L, Kopf, Gregory S, Johnston, Daniel S
Published in Biology of reproduction (01.04.2007)
Published in Biology of reproduction (01.04.2007)
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Journal Article
Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity
Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John, Gough, Peter J.
Published in The Journal of biological chemistry (07.09.2012)
Published in The Journal of biological chemistry (07.09.2012)
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Journal Article
Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues
Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells
Johnston, Daniel S, Jelinsky, Scott A, Zhi, Yu, Finger, Joshua N, Kopf, Gregory S, Wright, William W
Published in Annals of the New York Academy of Sciences (01.12.2007)
Published in Annals of the New York Academy of Sciences (01.12.2007)
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Journal Article
Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK 1 inhibitors in cells and tissues
Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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