Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
Findlay Black, Hailey, Wright, Galen E. B., Collins, Jennifer A., Caron, Nicholas, Kay, Chris, Xia, Qingwen, Arning, Larissa, Bijlsma, Emilia K., Squitieri, Ferdinando, Nguyen, Huu Phuc, Hayden, Michael R.
Published in Genetics in medicine (01.12.2020)
Published in Genetics in medicine (01.12.2020)
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Journal Article
A competence-regulated toxin-antitoxin system in Haemophilus influenzae
Findlay Black, Hailey, Mastromatteo, Scott, Sinha, Sunita, Ehrlich, Rachel L, Nislow, Corey, Chang Mell, Joshua, Redfield, Rosemary J
Published in PloS one (01.01.2020)
Published in PloS one (01.01.2020)
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Journal Article
Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies
Wright, Galen E B, Black, Hailey Findlay, Collins, Jennifer A, Gall-Duncan, Terence, Caron, Nicholas S, Pearson, Christopher E, Hayden, Michael R
Published in Lancet neurology (01.11.2020)
Published in Lancet neurology (01.11.2020)
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Journal Article
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease
Caron, Nicholas S, Banos, Raul, Yanick, Christopher, Aly, Amirah E, Byrne, Lauren M, Smith, Ethan D, Xie, Yuanyun, Smith, Stephen E P, Potluri, Nalini, Findlay Black, Hailey, Casal, Lorenzo, Ko, Seunghyun, Cheung, Daphne, Kim, Hyeongju, Seong, Ihn Sik, Wild, Edward J, Song, Ji-Joon, Hayden, Michael R, Southwell, Amber L
Published in The Journal of neuroscience (27.01.2021)
Published in The Journal of neuroscience (27.01.2021)
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Journal Article
D16 Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
Caron, Nicholas S, Haqqani, Arsalan S, Sandhu, Akshdeep, Aly, Amirah E, Findlay Black, Hailey, Bone, Jeffrey N, McBride, Jodi L, Abulrob, Abedelnasser, Stanimirovic, Danica, Leavitt, Blair R, Hayden, Michael R
Published in Journal of neurology, neurosurgery and psychiatry (12.09.2022)
Published in Journal of neurology, neurosurgery and psychiatry (12.09.2022)
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Journal Article
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, Amber L, Kordasiewicz, Holly B, Langbehn, Douglas, Skotte, Niels H, Parsons, Matthew P, Villanueva, Erika B, Caron, Nicholas S, Østergaard, Michael E, Anderson, Lisa M, Xie, Yuanyun, Cengio, Louisa Dal, Findlay-Black, Hailey, Doty, Crystal N, Fitsimmons, Bethany, Swayze, Eric E, Seth, Punit P, Raymond, Lynn A, Frank Bennett, C, Hayden, Michael R
Published in Science translational medicine (03.10.2018)
Published in Science translational medicine (03.10.2018)
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Journal Article
Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice
Caron, Nicholas S., Banos, Raul, Aly, Amirah E., Xie, Yuanyun, Ko, Seunghyun, Potluri, Nalini, Anderson, Christine, Black, Hailey Findlay, Anderson, Lisa M., Gordon, Benjamin, Southwell, Amber L., Hayden, Michael R.
Published in Neurobiology of disease (01.05.2022)
Published in Neurobiology of disease (01.05.2022)
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Journal Article
Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease
Caron, Nicholas S., Aly, Amirah E.-E., Findlay Black, Hailey, Martin, Dale D.O., Schmidt, Mandi E., Ko, Seunghyun, Anderson, Christine, Harvey, Emily M., Casal, Lorenzo L., Anderson, Lisa M., Rahavi, Seyed M.R., Reid, Gregor S.D., Oda, Michael N., Stanimirovic, Danica, Abulrob, Abedelnasser, McBride, Jodi L., Leavitt, Blair R., Hayden, Michael R.
Published in Journal of controlled release (01.03.2024)
Published in Journal of controlled release (01.03.2024)
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Journal Article
Ascertainment of uninterrupted CAG repeat length and disease-modifying variants in fragment-based genetic testing for Huntington Disease
Findlay Black, Hailey, Kay, Chris, Dawson, Jessica, Bortnick, Stephanie, Javier, Kyla, Xia, Qingwen, Chau, Cheuk Hin, Leavitt, Tess, Arning, Larissa, Nguyen, Huu Phuc, Hayden, Michael R.
Published in Genetics in Medicine Open (2024)
Published in Genetics in Medicine Open (2024)
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Journal Article
Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting
Caron, Nicholas S., Anderson, Christine, Black, Hailey Findlay, Sanders, Shaun S., Lemarié, Fanny L., Doty, Crystal N., Hayden, Michael R.
Published in Journal of Huntington's disease (01.01.2021)
Published in Journal of Huntington's disease (01.01.2021)
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Journal Article
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
Caron, Nicholas S, Southwell, Amber L, Brouwers, Cynthia C, Cengio, Louisa Dal, Xie, Yuanyun, Black, Hailey Findlay, Anderson, Lisa M, Ko, Seunghyun, Zhu, Xiang, van Deventer, Sander J, Evers, Melvin M, Konstantinova, Pavlina, Hayden, Michael R
Published in Nucleic acids research (10.01.2020)
Published in Nucleic acids research (10.01.2020)
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Journal Article
The frequency and clinical impact of synonymous HTT loss-of-interruption and duplication-of-interruption variants in a diverse HD cohort
Dawson, Jessica, Kay, Chris, Black, Hailey Findlay, Bortnick, Stephanie, Javier, Kyla, Xia, Qingwen, Sandhu, Akshdeep, Buchanan, Christina, Hogg, Virginia, Chang, Florence C.F., Goto, Jun, Arning, Larissa, Saft, Carsten, Bijlsma, Emilia K., Nguyen, Huu P., Roxburgh, Richard, Hayden, Michael R.
Published in Genetics in medicine (01.11.2024)
Published in Genetics in medicine (01.11.2024)
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Journal Article
A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease
Kay, Chris, Collins, Jennifer A., Caron, Nicholas S., Agostinho, Luciana de Andrade, Findlay-Black, Hailey, Casal, Lorenzo, Sumathipala, Dulika, Dissanayake, Vajira H.W., Cornejo-Olivas, Mario, Baine, Fiona, Krause, Amanda, Greenberg, Jacquie L., Paiva, Carmen Lúcia Antão, Squitieri, Ferdinando, Hayden, Michael R.
Published in American journal of human genetics (05.12.2019)
Published in American journal of human genetics (05.12.2019)
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Journal Article
Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks
Aly, Amirah E.-E., Caron, Nicholas S., Black, Hailey Findlay, Schmidt, Mandi E., Anderson, Christine, Ko, Seunghyun, Baddeley, Helen J.E., Anderson, Lisa, Casal, Lorenzo L., Rahavi, Reza S.M., Martin, Dale D.O., Hayden, Michael R.
Published in Journal of controlled release (01.08.2023)
Published in Journal of controlled release (01.08.2023)
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Journal Article
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
Caron, Nicholas S, Haqqani, Arsalan S, Sandhu, Akshdeep, Aly, Amirah E, Findlay Black, Hailey, Bone, Jeffrey N, McBride, Jodi L, Abulrob, Abedelnasser, Stanimirovic, Danica, Leavitt, Blair R, Hayden, Michael R
Published in Brain communications (2022)
Published in Brain communications (2022)
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Journal Article
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, Amber L, Skotte, Niels H, Villanueva, Erika B, Østergaard, Michael E, Gu, Xiaofeng, Kordasiewicz, Holly B, Kay, Chris, Cheung, Daphne, Xie, Yuanyun, Waltl, Sabine, Dal Cengio, Louisa, Findlay-Black, Hailey, Doty, Crystal N, Petoukhov, Eugenia, Iworima, Diepiriye, Slama, Ramy, Ooi, Jolene, Pouladi, Mahmoud A, Yang, X William, Swayze, Eric E, Seth, Punit P, Hayden, Michael R
Published in Human molecular genetics (15.03.2017)
Published in Human molecular genetics (15.03.2017)
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Journal Article
Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification
Harding, Rachel J, Xie, Yuanyun, Caron, Nicholas S, Findlay-Black, Hailey, Lyu, Caroline, Potluri, Nalini, Chandrasekaran, Renu, Hayden, Michael R, Leavitt, Blair R, Langbehn, Douglas R, Southwell, Amber L
Published in bioRxiv (27.09.2024)
Published in bioRxiv (27.09.2024)
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