Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety
He, Rongjun, Finan, Brian, Mayer, John P, DiMarchi, Richard D
Published in Molecules (Basel, Switzerland) (14.05.2019)
Published in Molecules (Basel, Switzerland) (14.05.2019)
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Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
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Published in Physiological reviews (01.07.2012)
Published in Physiological reviews (01.07.2012)
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Reappraisal of GIP Pharmacology for Metabolic Diseases
Finan, Brian, Müller, Timo D, Clemmensen, Christoffer, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Trends in molecular medicine (01.05.2016)
Published in Trends in molecular medicine (01.05.2016)
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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
Klein, Anders B., Nicolaisen, Trine S., Ørtenblad, Niels, Gejl, Kasper D., Jensen, Rasmus, Fritzen, Andreas M., Larsen, Emil L., Karstoft, Kristian, Poulsen, Henrik E., Morville, Thomas, Sahl, Ronni E., Helge, Jørn W., Lund, Jens, Falk, Sarah, Lyngbæk, Mark, Ellingsgaard, Helga, Pedersen, Bente K., Lu, Wei, Finan, Brian, Jørgensen, Sebastian B., Seeley, Randy J., Kleinert, Maximilian, Kiens, Bente, Richter, Erik A., Clemmensen, Christoffer
Published in Nature communications (15.02.2021)
Published in Nature communications (15.02.2021)
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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
Finan, Brian, Ma, Tao, Ottaway, Nickki, Müller, Timo D, Habegger, Kirk M, Heppner, Kristy M, Kirchner, Henriette, Holland, Jenna, Hembree, Jazzminn, Raver, Christine, Lockie, Sarah H, Smiley, David L, Gelfanov, Vasily, Yang, Bin, Hofmann, Susanna, Bruemmer, Dennis, Drucker, Daniel J, Pfluger, Paul T, Perez-Tilve, Diego, Gidda, Jaswant, Vignati, Louis, Zhang, Lianshan, Hauptman, Jonathan B, Lau, Michele, Brecheisen, Mathieu, Uhles, Sabine, Riboulet, William, Hainaut, Emmanuelle, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, DiMarchi, Richard D, Tschöp, Matthias H
Published in Science translational medicine (30.10.2013)
Published in Science translational medicine (30.10.2013)
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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
Knerr, Patrick J., Mowery, Stephanie A., Douros, Jonathan D., Premdjee, Bhavesh, Hjøllund, Karina Rahr, He, Yantao, Kruse Hansen, Ann Maria, Olsen, Anette K., Perez-Tilve, Diego, DiMarchi, Richard D., Finan, Brian
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
Novikoff, Aaron, O'Brien, Shannon L., Bernecker, Miriam, Grandl, Gerald, Kleinert, Maximilian, Knerr, Patrick J., Stemmer, Kerstin, Klingenspor, Martin, Zeigerer, Anja, DiMarchi, Richard, Tschöp, Matthias H., Finan, Brian, Calebiro, Davide, Müller, Timo D.
Published in Molecular metabolism (Germany) (01.07.2021)
Published in Molecular metabolism (Germany) (01.07.2021)
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GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet
CLEMMENSEN, Christoffer, CHABENNE, Joseph, PFLUGER, Paul T, PINKSTAFF, Jason, TSCHOP, Matthias H, DIMARCHI, Richard, MÜLLER, Timo D, FINAN, Brian, SULLIVAN, Lorraine, FISCHER, Katrin, KÜCHLER, Daniela, SEHRER, Laura, OGRAJSEK, Teja, HOFMANN, Susanna M, SCHRIEVER, Sonja C
Published in Diabetes (New York, N.Y.) (01.04.2014)
Published in Diabetes (New York, N.Y.) (01.04.2014)
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Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH
Finan, Brian, Parlee, Sebastian D., Yang, Bin
Published in Molecular metabolism (Germany) (01.04.2021)
Published in Molecular metabolism (Germany) (01.04.2021)
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Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα
Morselli, Eugenia, Fuente-Martin, Esther, Finan, Brian, Kim, Min, Frank, Aaron, Garcia-Caceres, Cristina, Navas, Carlos Rodriguez, Gordillo, Ruth, Neinast, Michael, Kalainayakan, Sarada P., Li, Dan L., Gao, Yuanqing, Yi, Chun-Xia, Hahner, Lisa, Palmer, Biff F., Tschöp, Matthias H., Clegg, Deborah J.
Published in Cell reports (Cambridge) (23.10.2014)
Published in Cell reports (Cambridge) (23.10.2014)
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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Jall, Sigrid, Sachs, Stephan, Clemmensen, Christoffer, Finan, Brian, Neff, Frauke, DiMarchi, Richard D, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M
Published in Molecular metabolism (Germany) (01.05.2017)
Published in Molecular metabolism (Germany) (01.05.2017)
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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Sánchez-Garrido, Miguel A., Serrano-López, Víctor, Ruiz-Pino, Francisco, Vázquez, María Jesús, Rodríguez-Martín, Andrea, Torres, Encarnación, Velasco, Inmaculada, Rodríguez, Ana Belén, Chicano-Gálvez, Eduardo, Mora-Ortiz, Marina, Ohlsson, Claes, Poutanen, Matti, Pinilla, Leonor, Gaytán, Francisco, Douros, Jonathan D., Yang, Bin, Müller, Timo D., DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, Tena-Sempere, Manuel
Published in Nature communications (01.10.2024)
Published in Nature communications (01.10.2024)
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.
Published in Nature communications (23.10.2018)
Published in Nature communications (23.10.2018)
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Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
Sachs, Stephan, Götz, Anna, Finan, Brian, Feuchtinger, Annette, DiMarchi, Richard D, Döring, Yvonne, Weber, Christian, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M
Published in Cardiovascular diabetology (12.09.2024)
Published in Cardiovascular diabetology (12.09.2024)
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Pharmacological antagonism of the incretin system protects against diet-induced obesity
Svendsen, Berit, Capozzi, Megan E., Nui, Jingjing, Hannou, Sarah A., Finan, Brian, Naylor, Jacqueline, Ravn, Peter, D'Alessio, David A., Campbell, Jonathan E.
Published in Molecular metabolism (Germany) (01.02.2020)
Published in Molecular metabolism (Germany) (01.02.2020)
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Hypothalamic leptin action is mediated by histone deacetylase 5
Kabra, Dhiraj G., Pfuhlmann, Katrin, García-Cáceres, Cristina, Schriever, Sonja C., Casquero García, Veronica, Kebede, Adam Fiseha, Fuente-Martin, Esther, Trivedi, Chitrang, Heppner, Kristy, Uhlenhaut, N. Henriette, Legutko, Beata, Kabra, Uma D., Gao, Yuanqing, Yi, Chun-Xia, Quarta, Carmelo, Clemmensen, Christoffer, Finan, Brian, Müller, Timo D., Meyer, Carola W., Paez-Pereda, Marcelo, Stemmer, Kerstin, Woods, Stephen C., Perez-Tilve, Diego, Schneider, Robert, Olson, Eric N., Tschöp, Matthias H., Pfluger, Paul T.
Published in Nature communications (29.02.2016)
Published in Nature communications (29.02.2016)
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The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
Fischer, Katrin, Fenzl, Anna, Liu, Dianxin, Dyar, Kenneth A., Kleinert, Maximilian, Brielmeier, Markus, Clemmensen, Christoffer, Fedl, Anna, Finan, Brian, Gessner, Andre, Jastroch, Martin, Huang, Jianfeng, Keipert, Susanne, Klingenspor, Martin, Brüning, Jens C., Kneilling, Manfred, Maier, Florian C., Othman, Ahmed E., Pichler, Bernd J., Pramme-Steinwachs, Ines, Sachs, Stephan, Scheideler, Angelika, Thaiss, Wolfgang M., Uhlenhaut, Henriette, Ussar, Siegfried, Woods, Stephen C., Zorn, Julia, Stemmer, Kerstin, Collins, Sheila, Diaz-Meco, Maria, Moscat, Jorge, Tschöp, Matthias H., Müller, Timo D.
Published in Nature communications (08.05.2020)
Published in Nature communications (08.05.2020)
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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
Sachs, Stephan, Götz, Anna, Finan, Brian, Feuchtinger, Annette, DiMarchi, Richard D, Döring, Yvonne, Weber, Christian, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M
Published in Cardiovascular diabetology (17.08.2023)
Published in Cardiovascular diabetology (17.08.2023)
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