Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Venteicher, Andrew S., Tirosh, Itay, Hebert, Christine, Yizhak, Keren, Neftel, Cyril, Filbin, Mariella G., Hovestadt, Volker, Escalante, Leah E., Shaw, McKenzie L., Rodman, Christopher, Gillespie, Shawn M., Dionne, Danielle, Luo, Christina C., Ravichandran, Hiranmayi, Mylvaganam, Ravindra, Mount, Christopher, Onozato, Maristela L., Nahed, Brian V., Wakimoto, Hiroaki, Curry, William T., Iafrate, A. John, Rivera, Miguel N., Frosch, Matthew P., Golub, Todd R., Brastianos, Priscilla K., Getz, Gad, Patel, Anoop P., Monje, Michelle, Cahill, Daniel P., Rozenblatt-Rosen, Orit, Louis, David N., Bernstein, Bradley E., Regev, Aviv, Suvà, Mario L.
Published in Science (American Association for the Advancement of Science) (31.03.2017)
Published in Science (American Association for the Advancement of Science) (31.03.2017)
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Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
Lin, Grant L, Nagaraja, Surya, Filbin, Mariella G, Suvà, Mario L, Vogel, Hannes, Monje, Michelle
Published in Acta neuropathologica communications (28.06.2018)
Published in Acta neuropathologica communications (28.06.2018)
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Molecular and clinicopathologic features of gliomas harboring NTRK fusions
Torre, Matthew, Vasudevaraja, Varshini, Serrano, Jonathan, DeLorenzo, Michael, Malinowski, Seth, Blandin, Anne-Florence, Pages, Melanie, Ligon, Azra H, Dong, Fei, Meredith, David M, Nasrallah, MacLean P, Horbinski, Craig, Dahiya, Sonika, Ligon, Keith L, Santi, Mariarita, Ramkissoon, Shakti H, Filbin, Mariella G, Snuderl, Matija, Alexandrescu, Sanda
Published in Acta neuropathologica communications (14.07.2020)
Published in Acta neuropathologica communications (14.07.2020)
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Reitman, Zachary J, Paolella, Brenton R, Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E, Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T, Sun, Yu, Weatherbee, Jessica L, Alberta, John A, Daley, John F, Rozenblatt-Rosen, Orit, Condurat, Alexandra L, Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A, Haas-Kogan, Daphne, Filbin, Mariella G, Suva, Mario L, Regev, Aviv, Stiles, Charles D, Kieran, Mark W, Goumnerova, Liliana, Ligon, Keith L, Shalek, Alex K, Bandopadhayay, Pratiti, Beroukhim, Rameen
Published in Nature communications (19.08.2019)
Published in Nature communications (19.08.2019)
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Immunotherapy approaches for the treatment of diffuse midline gliomas
Bernstock, Joshua D., Hoffman, Samantha E., Kappel, Ari D., Valdes, Pablo A., Essayed, Walid Ibn, Klinger, Neil V., Kang, Kyung-Don, Totsch, Stacie K., Olsen, Hannah E., Schlappi, Charles W., Filipski, Katharina, Gessler, Florian A., Baird, Lissa, Filbin, Mariella G., Hashizume, Rintaro, Becher, Oren J., Friedman, Gregory K.
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Pun, Matthew, Pratt, Drew, Nano, Patricia R, Joshi, Piyush K, Jiang, Li, Englinger, Bernhard, Rao, Arvind, Cieslik, Marcin, Chinnaiyan, Arul M, Aldape, Kenneth, Pfister, Stefan, Filbin, Mariella G, Bhaduri, Aparna, Venneti, Sriram
Published in Acta neuropathologica communications (09.02.2023)
Published in Acta neuropathologica communications (09.02.2023)
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system
So, Jonathan, Mabe, Nathaniel W, Englinger, Bernhard, Chow, Kin-Hoe, Moyer, Sydney M, Yerrum, Smitha, Trissal, Maria C, Marques, Joana G, Kwon, Jason J, Shim, Brian, Pal, Sangita, Panditharatna, Eshini, Quinn, Thomas, Schaefer, Daniel A, Jeong, Daeun, Mayhew, David L, Hwang, Justin, Beroukhim, Rameen, Ligon, Keith L, Stegmaier, Kimberly, Filbin, Mariella G, Hahn, William C
Published in JCI insight (10.10.2022)
Published in JCI insight (10.10.2022)
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An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Neftel, Cyril, Laffy, Julie, Filbin, Mariella G., Hara, Toshiro, Shore, Marni E., Rahme, Gilbert J., Richman, Alyssa R., Silverbush, Dana, Shaw, McKenzie L., Hebert, Christine M., Dewitt, John, Gritsch, Simon, Perez, Elizabeth M., Gonzalez Castro, L. Nicolas, Lan, Xiaoyang, Druck, Nicholas, Rodman, Christopher, Dionne, Danielle, Kaplan, Alexander, Bertalan, Mia S., Small, Julia, Pelton, Kristine, Becker, Sarah, Bonal, Dennis, Nguyen, Quang-De, Servis, Rachel L., Fung, Jeremy M., Mylvaganam, Ravindra, Mayr, Lisa, Gojo, Johannes, Haberler, Christine, Geyeregger, Rene, Czech, Thomas, Slavc, Irene, Nahed, Brian V., Curry, William T., Carter, Bob S., Wakimoto, Hiroaki, Brastianos, Priscilla K., Batchelor, Tracy T., Stemmer-Rachamimov, Anat, Martinez-Lage, Maria, Frosch, Matthew P., Stamenkovic, Ivan, Riggi, Nicolo, Rheinbay, Esther, Monje, Michelle, Rozenblatt-Rosen, Orit, Cahill, Daniel P., Patel, Anoop P., Hunter, Tony, Verma, Inder M., Ligon, Keith L., Louis, David N., Regev, Aviv, Bernstein, Bradley E., Tirosh, Itay, Suvà, Mario L.
Published in Cell (08.08.2019)
Published in Cell (08.08.2019)
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GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Majzner, Robbie G, Ramakrishna, Sneha, Yeom, Kristen W, Patel, Shabnum, Chinnasamy, Harshini, Schultz, Liora M, Richards, Rebecca M, Jiang, Li, Barsan, Valentin, Mancusi, Rebecca, Geraghty, Anna C, Good, Zinaida, Mochizuki, Aaron Y, Gillespie, Shawn M, Toland, Angus Martin Shaw, Mahdi, Jasia, Reschke, Agnes, Nie, Esther H, Chau, Isabelle J, Rotiroti, Maria Caterina, Mount, Christopher W, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Erickson, Courtney, Green, Sean, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Reynolds, Warren, Kurra, Sreevidya, Warren, Katherine E, Prabhu, Snehit, Vogel, Hannes, Rasmussen, Lindsey, Cornell, Timothy T, Partap, Sonia, Fisher, Paul G, Campen, Cynthia J, Filbin, Mariella G, Grant, Gerald, Sahaf, Bita, Davis, Kara L, Feldman, Steven A, Mackall, Crystal L, Monje, Michelle
Published in Nature (London) (31.03.2022)
Published in Nature (London) (31.03.2022)
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Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
Nagaraja, Surya, Quezada, Michael A., Gillespie, Shawn M., Arzt, Marlene, Lennon, James J., Woo, Pamelyn J., Hovestadt, Volker, Kambhampati, Madhuri, Filbin, Mariella G., Suva, Mario L., Nazarian, Javad, Monje, Michelle
Published in Molecular cell (19.12.2019)
Published in Molecular cell (19.12.2019)
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Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, Itay, Venteicher, Andrew S, Hebert, Christine, Escalante, Leah E, Patel, Anoop P, Yizhak, Keren, Fisher, Jonathan M, Rodman, Christopher, Mount, Christopher, Filbin, Mariella G, Neftel, Cyril, Desai, Niyati, Nyman, Jackson, Izar, Benjamin, Luo, Christina C, Francis, Joshua M, Patel, Aanand A, Onozato, Maristela L, Riggi, Nicolo, Livak, Kenneth J, Gennert, Dave, Satija, Rahul, Nahed, Brian V, Curry, William T, Martuza, Robert L, Mylvaganam, Ravindra, Iafrate, A John, Frosch, Matthew P, Golub, Todd R, Rivera, Miguel N, Getz, Gad, Rozenblatt-Rosen, Orit, Cahill, Daniel P, Monje, Michelle, Bernstein, Bradley E, Louis, David N, Regev, Aviv, Suvà, Mario L
Published in Nature (London) (10.11.2016)
Published in Nature (London) (10.11.2016)
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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
Anastas, Jamie N., Zee, Barry M., Kalin, Jay H., Kim, Mirhee, Guo, Robyn, Alexandrescu, Sanda, Blanco, Mario Andres, Giera, Stefanie, Gillespie, Shawn M., Das, Jayanta, Wu, Muzhou, Nocco, Sarah, Bonal, Dennis M., Nguyen, Quang-De, Suva, Mario L., Bernstein, Bradley E., Alani, Rhoda, Golub, Todd R., Cole, Philip A., Filbin, Mariella G., Shi, Yang
Published in Cancer cell (11.11.2019)
Published in Cancer cell (11.11.2019)
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Resolving medulloblastoma cellular architecture by single-cell genomics
Hovestadt, Volker, Smith, Kyle S, Bihannic, Laure, Filbin, Mariella G, Shaw, McKenzie L, Baumgartner, Alicia, DeWitt, John C, Groves, Andrew, Mayr, Lisa, Weisman, Hannah R, Richman, Alyssa R, Shore, Marni E, Goumnerova, Liliana, Rosencrance, Celeste, Carter, Robert A, Phoenix, Timothy N, Hadley, Jennifer L, Tong, Yiai, Houston, Jim, Ashmun, Richard A, DeCuypere, Michael, Sharma, Tanvi, Flasch, Diane, Silkov, Antonina, Ligon, Keith L, Pomeroy, Scott L, Rivera, Miguel N, Rozenblatt-Rosen, Orit, Rusert, Jessica M, Wechsler-Reya, Robert J, Li, Xiao-Nan, Peyrl, Andreas, Gojo, Johannes, Kirchhofer, Dominik, Lötsch, Daniela, Czech, Thomas, Dorfer, Christian, Haberler, Christine, Geyeregger, Rene, Halfmann, Angela, Gawad, Charles, Easton, John, Pfister, Stefan M, Regev, Aviv, Gajjar, Amar, Orr, Brent A, Slavc, Irene, Robinson, Giles W, Bernstein, Bradley E, Suvà, Mario L, Northcott, Paul A
Published in Nature (London) (01.08.2019)
Published in Nature (London) (01.08.2019)
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Stalled developmental programs at the root of pediatric brain tumors
Jessa, Selin, Blanchet-Cohen, Alexis, Krug, Brian, Vladoiu, Maria, Coutelier, Marie, Faury, Damien, Poreau, Brice, De Jay, Nicolas, Hébert, Steven, Monlong, Jean, Farmer, W Todd, Donovan, Laura K, Hu, Yixing, McConechy, Melissa K, Cavalli, Florence M G, Mikael, Leonie G, Ellezam, Benjamin, Richer, Maxime, Allaire, Andréa, Weil, Alexander G, Atkinson, Jeffrey, Farmer, Jean-Pierre, Dudley, Roy W R, Larouche, Valerie, Crevier, Louis, Albrecht, Steffen, Filbin, Mariella G, Sartelet, Hervé, Lutz, Pierre-Eric, Nagy, Corina, Turecki, Gustavo, Costantino, Santiago, Dirks, Peter B, Murai, Keith K, Bourque, Guillaume, Ragoussis, Jiannis, Garzia, Livia, Taylor, Michael D, Jabado, Nada, Kleinman, Claudia L
Published in Nature genetics (01.12.2019)
Published in Nature genetics (01.12.2019)
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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Chen, Carol C.L., Deshmukh, Shriya, Jessa, Selin, Hadjadj, Djihad, Lisi, Véronique, Andrade, Augusto Faria, Faury, Damien, Jawhar, Wajih, Dali, Rola, Suzuki, Hiromichi, Pathania, Manav, A, Deli, Dubois, Frank, Woodward, Eleanor, Hébert, Steven, Coutelier, Marie, Karamchandani, Jason, Albrecht, Steffen, Brandner, Sebastian, De Jay, Nicolas, Gayden, Tenzin, Bajic, Andrea, Harutyunyan, Ashot S., Marchione, Dylan M., Mikael, Leonie G., Juretic, Nikoleta, Zeinieh, Michele, Russo, Caterina, Maestro, Nicola, Bassenden, Angelia V., Hauser, Peter, Virga, József, Bognar, Laszlo, Klekner, Almos, Zapotocky, Michal, Vicha, Ales, Krskova, Lenka, Vanova, Katerina, Zamecnik, Josef, Sumerauer, David, Ekert, Paul G., Ziegler, David S., Ellezam, Benjamin, Filbin, Mariella G., Blanchette, Mathieu, Hansford, Jordan R., Khuong-Quang, Dong-Anh, Berghuis, Albert M., Weil, Alexander G., Garcia, Benjamin A., Garzia, Livia, Mack, Stephen C., Beroukhim, Rameen, Ligon, Keith L., Taylor, Michael D., Bandopadhayay, Pratiti, Kramm, Christoph, Pfister, Stefan M., Korshunov, Andrey, Sturm, Dominik, Jones, David T.W., Salomoni, Paolo, Kleinman, Claudia L., Jabado, Nada
Published in Cell (10.12.2020)
Published in Cell (10.12.2020)
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