Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Lopes, Noel, McIntyre, Claire, Martin, Stefania, Raverdeau, Mathilde, Sumaria, Nital, Kohlgruber, Ayano C., Fiala, Gina, Agudelo, Leandro Z., Dyck, Lydia, Kane, Harry, Douglas, Aaron, Cunningham, Stephen, Prendeville, Hannah, Loftus, Roisin, Carmody, Colleen, Pierre, Philippe, Kellis, Manolis, Brenner, Michael, Argüello, Rafael J., Silva-Santos, Bruno, Pennington, Daniel J., Lynch, Lydia
Published in Nature immunology (01.02.2021)
Published in Nature immunology (01.02.2021)
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Pro‐ and antitumorigenic functions of γδ T cells
Fiala, Gina J., Lücke, Jöran, Huber, Samuel
Published in European journal of immunology (01.08.2024)
Published in European journal of immunology (01.08.2024)
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From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation
Fiala, Gina J., Gomes, Anita Q., Silva‐Santos, Bruno
Published in Immunological reviews (01.11.2020)
Published in Immunological reviews (01.11.2020)
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Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Hartl, Frederike A., Beck-Garcìa, Esmeralda, Woessner, Nadine M., Flachsmann, Lea J., Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M., Taromi, Sanaz, Fiala, Gina J., Morath, Anna, Mishra, Pankaj, Yousefi, O. Sascha, Zimmermann, Julia, Hoefflin, Nico, Köhn, Maja, Wöhrl, Birgitta M., Zeiser, Robert, Schweimer, Kristian, Günther, Stefan, Schamel, Wolfgang W., Minguet, Susana
Published in Nature immunology (01.08.2020)
Published in Nature immunology (01.08.2020)
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The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex
Dolezal, Elmar, Infantino, Simona, Drepper, Friedel, Börsig, Theresa, Singh, Aparajita, Wossning, Thomas, Fiala, Gina J, Minguet, Susana, Warscheid, Bettina, Tarlinton, David M, Jumaa, Hassan, Medgyesi, David, Reth, Michael
Published in Nature immunology (01.08.2017)
Published in Nature immunology (01.08.2017)
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Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development
Fiala, Gina J, Schaffer, Anna-Maria, Merches, Katja, Morath, Anna, Swann, Jeremy, Herr, Laurenz A, Hils, Miriam, Esser, Charlotte, Minguet, Susana, Schamel, Wolfgang W A
Published in The Journal of immunology (1950) (15.07.2019)
Published in The Journal of immunology (1950) (15.07.2019)
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Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
Sumaria, Nital, Fiala, Gina J., Inácio, Daniel, Curado-Avelar, Marta, Cachucho, Ana, Pinheiro, Rúben, Wiesheu, Robert, Kimura, Shunsuke, Courtois, Lucien, Blankenhaus, Birte, Darrigues, Julie, Suske, Tobias, Almeida, Afonso R. M., Minguet, Susana, Asnafi, Vahid, Lhermitte, Ludovic, Mullighan, Charles G., Coffelt, Seth B., Moriggl, Richard, Barata, João T., Pennington, Daniel J., Silva-Santos, Bruno
Published in Nature immunology (01.07.2024)
Published in Nature immunology (01.07.2024)
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A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency
Pieper, Kathrin, PhD, Rizzi, Marta, MD, PhD, Speletas, Matthaios, MD, PhD, Smulski, Cristian R., PhD, Sic, Heiko, PhD, Kraus, Helene, MSc, Salzer, Ulrich, MD, Fiala, Gina J., MSc, Schamel, Wolfgang W., PhD, Lougaris, Vassilios, MD, Plebani, Alessandro, MD, Hammarstrom, Lennart, MD, PhD, Recher, Mike, MD, Germenis, Anastasios E., MD, PhD, Grimbacher, Bodo, MD, Warnatz, Klaus, MD, PhD, Rolink, Antonius G., PhD, Schneider, Pascal, PhD, Notarangelo, Luigi D., MD, Eibel, Hermann, PhD
Published in Journal of allergy and clinical immunology (01.04.2014)
Published in Journal of allergy and clinical immunology (01.04.2014)
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Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance
Minguet, Susana, Kläsener, Kathrin, Schaffer, Anna-Maria, Fiala, Gina J, Osteso-Ibánez, Teresa, Raute, Katrin, Navarro-Lérida, Inmaculada, Hartl, Frederike A, Seidl, Maximilian, Reth, Michael, Del Pozo, Miguel A
Published in Nature immunology (01.10.2017)
Published in Nature immunology (01.10.2017)
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Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
Röring, Michael, Herr, Ricarda, Fiala, Gina J, Heilmann, Katharina, Braun, Sandra, Eisenhardt, Anja E, Halbach, Sebastian, Capper, David, von Deimling, Andreas, Schamel, Wolfgang W, Saunders, Darren N, Brummer, Tilman
Published in The EMBO journal (30.05.2012)
Published in The EMBO journal (30.05.2012)
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Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner
Papotto, Pedro H., Yilmaz, Bahtiyar, Pimenta, Gonçalo, Mensurado, Sofia, Cunha, Carolina, Fiala, Gina J., Gomes da Costa, Daniel, Gonçalves-Sousa, Natacha, Chan, Brian H.K., Blankenhaus, Birte, Domingues, Rita G., Carvalho, Tânia, Hepworth, Matthew R., Macpherson, Andrew J., Allen, Judith E., Silva-Santos, Bruno
Published in Cell reports (Cambridge) (28.02.2023)
Published in Cell reports (Cambridge) (28.02.2023)
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The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing
Dopfer, Elaine P., Hartl, Frederike A., Oberg, Hans-Heinrich, Siegers, Gabrielle M., Yousefi, O. Sascha, Kock, Sylvia, Fiala, Gina J., Garcillán, Beatriz, Sandstrom, Andrew, Alarcón, Balbino, Regueiro, Jose R., Kabelitz, Dieter, Adams, Erin J., Minguet, Susana, Wesch, Daniela, Fisch, Paul, Schamel, Wolfgang W.A.
Published in Cell reports (Cambridge) (12.06.2014)
Published in Cell reports (Cambridge) (12.06.2014)
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Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants
Köhler, Martin, Röring, Michael, Schorch, Björn, Heilmann, Katharina, Stickel, Natalie, Fiala, Gina J, Schmitt, Lisa C, Braun, Sandra, Ehrenfeld, Sophia, Uhl, Franziska M, Kaltenbacher, Thorsten, Weinberg, Florian, Herzog, Sebastian, Zeiser, Robert, Schamel, Wolfgang W, Jumaa, Hassan, Brummer, Tilman
Published in The EMBO journal (18.01.2016)
Published in The EMBO journal (18.01.2016)
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Author Correction: Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Hartl, Frederike A., Beck-Garcìa, Esmeralda, Woessner, Nadine M., Flachsmann, Lea J., Cárdenas, Rubí M.-H. Velasco, Brandl, Simon M., Taromi, Sanaz, Fiala, Gina J., Morath, Anna, Mishra, Pankaj, Yousefi, O. Sascha, Zimmermann, Julia, Hoefflin, Nico, Köhn, Maja, Wöhrl, Birgitta M., Zeiser, Robert, Schweimer, Kristian, Günther, Stefan, Schamel, Wolfgang W., Minguet, Susana
Published in Nature immunology (2021)
Published in Nature immunology (2021)
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Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation
Fiala, Gina J, Janowska, Iga, Prutek, Fabiola, Hobeika, Elias, Satapathy, Annyesha, Sprenger, Adrian, Plum, Thomas, Seidl, Maximilian, Dengjel, Jörn, Reth, Michael, Cesca, Fabrizia, Brummer, Tilman, Minguet, Susana, Schamel, Wolfgang W A
Published in The Journal of experimental medicine (21.09.2015)
Published in The Journal of experimental medicine (21.09.2015)
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Journal Article
The CD3 Conformational Change in the gamma delta T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing
Dopfer, Elaine P, Hartl, Frederike A, Oberg, Hans-Heinrich, Siegers, Gabrielle M, Yousefi, OSascha, Kock, Sylvia, Fiala, Gina J, Garcillan, Beatriz, Sandstrom, Andrew, Alarcon, Balbino, Regueiro, Jose R, Kabelitz, Dieter, Adams, Erin J, Minguet, Susana, Wesch, Daniela, Fisch, Paul, Schamel, Wolfgang WA
Published in Cell reports (Cambridge) (12.06.2014)
Published in Cell reports (Cambridge) (12.06.2014)
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Journal Article
Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals
Herr, Laurenz A, Fiala, Gina J, Sagar, Schaffer, Anna-Maria, Hummel, Jonas F, Zintchenko, Marina, Raute, Katrin, Velasco Cárdenas, Rubí M-H, Heizmann, Beate, Ebert, Karolina, Fehrenbach, Kerstin, Janowska, Iga, Chan, Susan, Tanriver, Yakup, Minguet, Susana, Schamel, Wolfgang W
Published in Science advances (15.03.2024)
Published in Science advances (15.03.2024)
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