ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
Fernandes, Hugo J.R., Hartfield, Elizabeth M., Christian, Helen C., Emmanoulidou, Evangelia, Zheng, Ying, Booth, Heather, Bogetofte, Helle, Lang, Charmaine, Ryan, Brent J., Sardi, S. Pablo, Badger, Jennifer, Vowles, Jane, Evetts, Samuel, Tofaris, George K., Vekrellis, Kostas, Talbot, Kevin, Hu, Michele T., James, William, Cowley, Sally A., Wade-Martins, Richard
Published in Stem cell reports (08.03.2016)
Published in Stem cell reports (08.03.2016)
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Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses
Fernandes, Hugo J.R., Patikas, Nikolaos, Foskolou, Stefanie, Field, Sarah F., Park, Jong-Eun, Byrne, Meg L., Bassett, Andrew R., Metzakopian, Emmanouil
Published in Cell reports (Cambridge) (13.10.2020)
Published in Cell reports (Cambridge) (13.10.2020)
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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
Bogetofte, Helle, Ryan, Brent J., Jensen, Pia, Schmidt, Sissel I., Vergoossen, Dana L.E., Barnkob, Mike B., Kiani, Lisa N., Chughtai, Uroosa, Heon-Roberts, Rachel, Caiazza, Maria Claudia, McGuinness, William, Márquez-Gómez, Ricardo, Vowles, Jane, Bunn, Fiona S., Brandes, Janine, Kilfeather, Peter, Connor, Jack P., Fernandes, Hugo J.R., Caffrey, Tara M., Meyer, Morten, Cowley, Sally A., Larsen, Martin R., Wade-Martins, Richard
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons
Snowden, Stuart G., Fernandes, Hugo J.R., Kent, Josh, Foskolou, Stefanie, Tate, Peri, Field, Sarah F., Metzakopian, Emmanouil, Koulman, Albert
Published in iScience (20.11.2020)
Published in iScience (20.11.2020)
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Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons
Zambon, Federico, Cherubini, Marta, Fernandes, Hugo J R, Lang, Charmaine, Ryan, Brent J, Volpato, Viola, Bengoa-Vergniory, Nora, Vingill, Siv, Attar, Moustafa, Booth, Heather D E, Haenseler, Walther, Vowles, Jane, Bowden, Rory, Webber, Caleb, Cowley, Sally A, Wade-Martins, Richard
Published in Human molecular genetics (15.06.2019)
Published in Human molecular genetics (15.06.2019)
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Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Published in Nature communications (18.04.2019)
Published in Nature communications (18.04.2019)
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Variant‐specific effects of GBA1 mutations on dopaminergic neuron proteostasis
Onal, G., Yalçın‐Çakmaklı, G., Özçelik, C. E., Boussaad, I., Şeker, U. Ö. Ş., Fernandes, Hugo J. R., Demir, H., Krüger, R., Elibol, B., Dökmeci, S., Salman, M. M.
Published in Journal of neurochemistry (01.09.2024)
Published in Journal of neurochemistry (01.09.2024)
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MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development
Parada, Guillermo E, Munita, Roberto, Georgakopoulos-Soares, Ilias, Fernandes, Hugo J R, Kedlian, Veronika R, Metzakopian, Emmanouil, Andres, Maria Estela, Miska, Eric A, Hemberg, Martin
Published in Genome Biology (22.01.2021)
Published in Genome Biology (22.01.2021)
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CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death
Pavlou, Sofia, Foskolou, Stefanie, Patikas, Nikolaos, Field, Sarah F., Papachristou, Evangelia K., Santos, Clive D’, Edwards, Abigail R., Kishore, Kamal, Ansari, Rizwan, Rajan, Sandeep S., Fernandes, Hugo J. R., Metzakopian, Emmanouil
Published in Scientific reports (09.03.2023)
Published in Scientific reports (09.03.2023)
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Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease
Vazquez-Arango, Pilar, Vowles, Jane, Browne, Cathy, Hartfield, Elizabeth, Fernandes, Hugo J R, Mandefro, Berhan, Sareen, Dhruv, James, William, Wade-Martins, Richard, Cowley, Sally A, Murphy, Shona, O'Reilly, Dawn
Published in Nucleic acids research (15.12.2016)
Published in Nucleic acids research (15.12.2016)
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Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT
Fernandes, Hugo J R, Kent, Josh P, Bruntraeger, Michaela, Bassett, Andrew R, Koulman, Albert, Metzakopian, Emmanouil, Snowden, Stuart G
Published in Metabolites (09.01.2023)
Published in Metabolites (09.01.2023)
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