Identification of Selective Inhibitors of Plasmodium N‑Myristoyltransferase by High-Throughput Screening
Harupa, Anke, De Las Heras, Laura, Colmenarejo, Gonzalo, Lyons-Abbott, Sally, Reers, Alexandra, Caballero Hernandez, Iván, Chung, Chun-Wa, Charter, David, Myler, Peter J, Fernández-Menéndez, Raquel M, Calderón, Félix, Palomo, Sara, Rodríguez, Beatriz, Berlanga, Manuela, Herreros-Avilés, Esperanza, Staker, Bart L, Fernández Álvaro, Elena, Kaushansky, Alexis
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
Get full text
Journal Article
Identification of and Structural Insights into Hit Compounds Targeting N‑Myristoyltransferase for Cryptosporidium Drug Development
Fenwick, Michael K., Reers, Alexandra R., Liu, Yi, Zigweid, Rachael, Sankaran, Banumathi, Shin, Janis, Hulverson, Matthew A., Hammerson, Bradley, Fernández Álvaro, Elena, Myler, Peter J., Kaushansky, Alexis, Van Voorhis, Wesley C., Fan, Erkang, Staker, Bart L.
Published in ACS infectious diseases (13.10.2023)
Published in ACS infectious diseases (13.10.2023)
Get full text
Journal Article
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp
Fernández Álvaro, Elena, Voong Vinh, Phat, de Cozar, Cristina, Willé, David R, Urones, Beatriz, Cortés, Alvaro, Price, Alan, Tran Do Hoang, Nhu, Ha Thanh, Tuyen, McCloskey, Molly, Shaheen, Shareef, Dayao, Denise, Martinot, Amanda, de Mercado, Jaime, Castañeda, Pablo, García-Perez, Adolfo, Singa, Benson, Pavlinac, Patricia, Walson, Judd, Martínez-Martínez, Maria Santos, Arnold, Samuel L M, Tzipori, Saul, Ballell Pages, Lluis, Baker, Stephen
Published in eLife (15.03.2022)
Published in eLife (15.03.2022)
Get full text
Journal Article
Correction: The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp
Fernández Álvaro, Elena, Voong Vinh, Phat, de Cozar, Cristina, Willé, David R, Urones, Beatriz, Cortés, Alvaro, Price, Alan, Tran Do Hoang, Nhu, Ha Thanh, Tuyen, McCloskey, Molly, Shaheen, Shareef, Dayao, Denise, Martinot, Amanda, de Mercado, Jaime, Castañeda, Pablo, García-Perez, Adolfo, Singa, Benson, Pavlinac, Patricia, Walson, Judd, Martínez-Martínez, Maria Santos, Arnold, Samuel LM, Tzipori, Saul, Pages, Lluis Ballell, Baker, Stephen
Published in eLife (05.09.2022)
Published in eLife (05.09.2022)
Get full text
Journal Article
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action
Fernández-Álvaro, Elena, Hong, W David, Nixon, Gemma L, O'Neill, Paul M, Calderón, Félix
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
Get full text
Journal Article
Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi
Mylona, Elli, Voong Vinh, Phat, Qureshi, Sonia, Karkey, Abhilasha, Dongol, Sabina, Ha Thanh, Tuyen, Walson, Judd, Ballell, Lluis, Fernández Álvaro, Elena, Qamar, Farah, Baker, Stephen
Published in Journal of antimicrobial chemotherapy (12.11.2021)
Published in Journal of antimicrobial chemotherapy (12.11.2021)
Get full text
Journal Article
Lead Optimization of Dehydroemetine for Repositioned Use in Malaria
Panwar, Priyanka, Burusco, Kepa K, Abubaker, Muna, Matthews, Holly, Gutnov, Andrey, Fernández-Álvaro, Elena, Bryce, Richard A, Wilkinson, James, Nirmalan, Niroshini
Published in Antimicrobial agents and chemotherapy (24.03.2020)
Published in Antimicrobial agents and chemotherapy (24.03.2020)
Get full text
Journal Article
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action: Miniperspective
Fernández-Álvaro, Elena, Hong, W. David, Nixon, Gemma L, O’Neill, Paul M, Calderón, Félix
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
Get full text
Journal Article
Assessing biocatalysis for the synthesis of optically active tetrahydropyrazolo[1,5-α]pyrimidines (THPPs) as novel therapeutic agents
Fernández-Álvaro, Elena, Esquivias, Jorge, Pérez-Sánchez, María, Domínguez de María, Pablo, Remuiñán-Blanco, Modesto J.
Published in Journal of molecular catalysis. B, Enzymatic (01.02.2014)
Published in Journal of molecular catalysis. B, Enzymatic (01.02.2014)
Get full text
Journal Article
Eine Kombination aus In-vivo-Selektion und Zellsortierung zur Identifizierung enantioselektiver Biokatalysatoren
Fernández-Álvaro, Elena, Snajdrova, Radka, Jochens, Helge, Davids, Timo, Böttcher, Dominique, Bornscheuer, Uwe T.
Published in Angewandte Chemie (05.09.2011)
Published in Angewandte Chemie (05.09.2011)
Get full text
Journal Article
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites
Matralis, Alexios N, Malik, Adnan, Penzo, Maria, Moreno, Inmaculada, Almela, Maria J, Camino, Isabel, Crespo, Benigno, Saadeddin, Anas, Ghidelli-Disse, Sonja, Rueda, Lourdes, Calderon, Felix, Osborne, Simon A, Drewes, Gerard, Böesche, Markus, Fernández-Álvaro, Elena, Martin Hernando, Jose Ignacio, Baker, David A
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
Get full text
Journal Article
A Combination of In Vivo Selection and Cell Sorting for the Identification of Enantioselective Biocatalysts
Fernández-Álvaro, Elena, Snajdrova, Radka, Jochens, Helge, Davids, Timo, Böttcher, Dominique, Bornscheuer, Uwe T.
Published in Angewandte Chemie International Edition (05.09.2011)
Published in Angewandte Chemie International Edition (05.09.2011)
Get full text
Journal Article
The crystal structure of an esterase from the hyperthermophilic microorganism Pyrobaculum calidifontis VA1 explains its enantioselectivity
Palm, Gottfried J., Fernández-Álvaro, Elena, Bogdanović, Xenia, Bartsch, Sebastian, Sczodrok, Jaroslaw, Singh, Rajesh K., Böttcher, Dominique, Atomi, Haruyuki, Bornscheuer, Uwe T., Hinrichs, Winfried
Published in Applied microbiology and biotechnology (01.08.2011)
Published in Applied microbiology and biotechnology (01.08.2011)
Get full text
Journal Article
Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri
Miljkovic, Marija, Lozano, Sonia, Castellote, Isabel, de Cózar, Cristina, Villegas-Moreno, Ana I, Gamallo, Pablo, Jimenez-Alfaro Martinez, Dolores, Fernández-Álvaro, Elena, Ballell, Lluis, Garcia, George A
Published in mSphere (24.10.2023)
Published in mSphere (24.10.2023)
Get full text
Journal Article
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Published in Science (American Association for the Advancement of Science)
(30.08.2019)
Get full text
Journal Article
Animal models of efficacy to accelerate drug discovery in malaria
JIMÉNEZ-DÍAZ, MARÍA BELÉN, VIERA, SARA, FERNÁNDEZ-ALVARO, ELENA, ANGULO-BARTUREN, IÑIGO
Published in Parasitology (01.01.2014)
Published in Parasitology (01.01.2014)
Get full text
Journal Article
Eine Kombination aus In‐vivo‐Selektion und Zellsortierung zur Identifizierung enantioselektiver Biokatalysatoren
Fernández‐Álvaro, Elena, Snajdrova, Radka, Jochens, Helge, Davids, Timo, Böttcher, Dominique, Bornscheuer, Uwe T.
Published in Angewandte Chemie (05.09.2011)
Published in Angewandte Chemie (05.09.2011)
Get full text
Journal Article
Efforts Aimed To Reduce Attrition in Antimalarial Drug Discovery: A Systematic Evaluation of the Current Antimalarial Targets Portfolio
Chaparro, María Jesús, Calderón, Félix, Castañeda, Pablo, Fernández-Alvaro, Elena, Gabarró, Raquel, Gamo, Francisco Javier, Gómez-Lorenzo, María G, Martín, Julio, Fernández, Esther
Published in ACS infectious diseases (13.04.2018)
Published in ACS infectious diseases (13.04.2018)
Get full text
Journal Article
Validation of the protein kinase Pf CLK3 as a multistage cross-species malarial drug target
Alam, Mahmood M, Sanchez-Azqueta, Ana, Janha, Omar, Flannery, Erika L, Mahindra, Amit, Mapesa, Kopano, Char, Aditya B, Sriranganadane, Dev, Brancucci, Nicolas M B, Antonova-Koch, Yevgeniya, Crouch, Kathryn, Simwela, Nelson Victor, Millar, Scott B, Akinwale, Jude, Mitcheson, Deborah, Solyakov, Lev, Dudek, Kate, Jones, Carolyn, Zapatero, Cleofé, Doerig, Christian, Nwakanma, Davis C, Vázquez, Maria Jesús, Colmenarejo, Gonzalo, Lafuente-Monasterio, Maria Jose, Leon, Maria Luisa, Godoi, Paulo H C, Elkins, Jon M, Waters, Andrew P, Jamieson, Andrew G, Álvaro, Elena Fernández, Ranford-Cartwright, Lisa C, Marti, Matthias, Winzeler, Elizabeth A, Gamo, Francisco Javier, Tobin, Andrew B
Published in Science (American Association for the Advancement of Science) (30.08.2019)
Published in Science (American Association for the Advancement of Science) (30.08.2019)
Get full text
Journal Article