Population Pharmacokinetic-Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin
Fernández-Teruel, Carlos, Lubomirov, Rubin, Fudio, Salvador
Published in Journal of clinical pharmacology (01.09.2021)
Published in Journal of clinical pharmacology (01.09.2021)
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Phase I/II study of weekly PM00104 (Zalypsis®) in patients with relapsed/refractory multiple myeloma
Ocio, Enrique M., Oriol, Albert, Bladé, Joan, Teruel, Ana I., Martín, Jesus, Rubia, Javier, Gutiérrez, Norma C., Rodríguez Díaz‐Pavón, José, Martínez González, Sara, Coronado, Cinthya, Fernández‐García, Eva M., Siguero Gómez, Mariano, Fernández‐Teruel, Carlos, San Miguel, Jesus
Published in British journal of haematology (01.02.2016)
Published in British journal of haematology (01.02.2016)
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Journal Article
Population Pharmacokinetic–Pharmacodynamic Analysis of Neutropenia in Cancer Patients Receiving PM00104 (Zalypsis®)
González-Sales, Mario, Valenzuela, Belén, Pérez-Ruixo, Carlos, Fernández Teruel, Carlos, Miguel-Lillo, Bernardo, Soto-Matos, Arturo, Pérez-Ruixo, Juan Jose
Published in Clinical pharmacokinetics (01.11.2012)
Published in Clinical pharmacokinetics (01.11.2012)
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A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies
Navarro-Fontestad, Carmen, González-Álvarez, Isabel, Fernández-Teruel, Carlos, Bermejo, Marival, Casabó, Vicente Germán
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.01.2012)
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.01.2012)
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In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results
González-Alvarez, Isabel, Fernández-Teruel, Carlos, Casabó-Alós, Vicente G., Garrigues, Teresa M., Polli, James E., Ruiz-García, Ana, Bermejo, Marival
Published in Biopharmaceutics & drug disposition (01.07.2007)
Published in Biopharmaceutics & drug disposition (01.07.2007)
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A topological-substructural molecular design (TOPS-MODE) approach to determining pharmacokinetics and pharmacological properties of 6-fluoroquinolone derivatives
Pérez, Miguel Angel Cabrera, Garcı́a, Ana Ruiz, Teruel, Carlos Fernández, Álvarez, Isabel González, Sanz, Marival Bermejo
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2003)
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2003)
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Journal Article
Population pharmacokinetics of PM00104 (Zalypsis®) in cancer patients
Pérez-Ruixo, Carlos, Valenzuela, Belén, Fernández Teruel, Carlos, González-Sales, Mario, Miguel-Lillo, Bernardo, Soto-Matos, Arturo, Pérez-Ruixo, Juan José
Published in Cancer chemotherapy and pharmacology (2012)
Published in Cancer chemotherapy and pharmacology (2012)
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Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies
Reig‐Lopez, Javier, Tang, Weifeng, Fernandez‐Teruel, Carlos, Merino‐Sanjuan, Matilde, Mangas‐Sanjuan, Victor, Boulton, David W., Sharma, Pradeep
Published in British journal of clinical pharmacology (01.09.2023)
Published in British journal of clinical pharmacology (01.09.2023)
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Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS
King, Nicholas, Garcia-Martinez, Soledad, Alcaraz, Eider, Grisalena, Alba, Lubomirov, Rubin, Altares, Raquel, Fernandez-Teruel, Carlos, Francesch, Andrés M, Avilés, Pablo M, Fudio, Salvador
Published in PloS one (30.03.2023)
Published in PloS one (30.03.2023)
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Journal Article
First-In-Human Phase I Study of Lurbinectedin (PM01183) in Patients with Advanced Solid Tumors
ELEZ, María Elena, TABERNERO, Josep, SZYLDERGEMAJN, Sergio, RATAIN, Mark J, GEARY, David, MACARULLA, Teresa, KANG, S. Peter, KAHATT, Carmen, PITA, Arturo Soto-Matos, TERUEL, Carlos Fernandez, SIGUERO, Mariano, CULLELL-YOUNG, Martin
Published in Clinical cancer research (15.04.2014)
Published in Clinical cancer research (15.04.2014)
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Journal Article
A novel approach to determining physicochemical and absorption properties of 6-fluoroquinolone derivatives: experimental assessment
Cabrera Pérez, Miguel Angel, González Dı́az, Humberto, Fernández Teruel, Carlos, Plá-Delfina, José M a, Bermejo Sanz, Marival
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2002)
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2002)
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Journal Article
Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors
Paz-Ares, Luis, Forster, Martin, Boni, Valentina, Szyldergemajn, Sergio, Corral, Jesús, Turnbull, Samantha, Cubillo, Antonio, Teruel, Carlos Fernandez, Calderero, Iker López, Siguero, Mariano, Bohan, Patrick, Calvo, Emiliano
Published in Investigational new drugs (01.04.2017)
Published in Investigational new drugs (01.04.2017)
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Journal Article
A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin
Grosso, Federica, D’Incalci, Maurizio, Cartoafa, Mirela, Nieto, Antonio, Fernández-Teruel, Carlos, Alfaro, Vicente, Lardelli, Pilar, Roy, Elena, Gómez, Javier, Kahatt, Carmen, Soto-Matos, Arturo, Judson, Ian
Published in Cancer chemotherapy and pharmacology (01.06.2012)
Published in Cancer chemotherapy and pharmacology (01.06.2012)
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Journal Article
Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors
Sessa, Cristiana, Del Conte, Gianluca, Christinat, Alexandre, Cresta, Sara, Perotti, Antonella, Gallerani, Elisa, Lardelli, Pilar, Kahatt, Carmen, Alfaro, Vicente, Iglesias, Jorge L., Fernández-Teruel, Carlos, Gianni, Luca
Published in Investigational new drugs (01.10.2013)
Published in Investigational new drugs (01.10.2013)
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Journal Article
Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors
Massard, Christophe, Margetts, Jane, Amellal, Nadia, Drew, Yvette, Bahleda, Ratislav, Stevens, Peter, Armand, Jean Pierre, Calvert, Hilary, Soria, Jean Charles, Coronado, Cinthya, Kahatt, Carmen, Alfaro, Vicente, Siguero, Mariano, Fernández-Teruel, Carlos, Plummer, Ruth
Published in Investigational new drugs (01.06.2013)
Published in Investigational new drugs (01.06.2013)
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Journal Article
Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors
Salazar, Ramón, Calles, Antonio, Gil, Marta, Durán, Ignacio, García, Margarita, Hidalgo, Manuel, Coronado, Cinthya, Alfaro, Vicente, Siguero, Mariano, Fernández-Teruel, Carlos, Prados, Raquel, Calvo, Emiliano
Published in Investigational new drugs (01.08.2014)
Published in Investigational new drugs (01.08.2014)
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Journal Article
Phase II clinical trial of PM00104 (Zalypsis®) in urothelial carcinoma patients progressing after first-line platinum-based regimen
Castellano, Daniel E., Bellmunt, Joaquim, Maroto, José Pablo, Font-Pous, Albert, Morales-Barrera, Rafael, Ghanem, Ismael, Suarez, Cristina, Martín Lorente, Cristina, Etxaniz, Olatz, Capdevila, Laia, Coronado, Cinthya, Alfaro, Vicente, Siguero, Mariano, Fernández-Teruel, Carlos, Carles, Joan
Published in Cancer chemotherapy and pharmacology (01.04.2014)
Published in Cancer chemotherapy and pharmacology (01.04.2014)
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