Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons
Tanudjojo, Benedict, Shaikh, Samiha S, Fenyi, Alexis, Bousset, Luc, Agarwal, Devika, Marsh, Jade, Zois, Christos, Heman-Ackah, Sabrina, Fischer, Roman, Sims, David, Melki, Ronald, Tofaris, George K
Published in Nature communications (21.06.2021)
Published in Nature communications (21.06.2021)
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The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
Van der Perren, Anke, Gelders, Géraldine, Fenyi, Alexis, Bousset, Luc, Brito, Filipa, Peelaerts, Wouter, Van den Haute, Chris, Gentleman, Steve, Melki, Ronald, Baekelandt, Veerle
Published in Acta neuropathologica (01.06.2020)
Published in Acta neuropathologica (01.06.2020)
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Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification
Fenyi, Alexis, Leclair-Visonneau, Laurène, Clairembault, Thomas, Coron, Emmanuel, Neunlist, Michel, Melki, Ronald, Derkinderen, Pascal, Bousset, Luc
Published in Neurobiology of disease (01.09.2019)
Published in Neurobiology of disease (01.09.2019)
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Journal Article
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
Gribaudo, Simona, Tixador, Philippe, Bousset, Luc, Fenyi, Alexis, Lino, Patricia, Melki, Ronald, Peyrin, Jean-Michel, Perrier, Anselme L.
Published in Stem cell reports (12.02.2019)
Published in Stem cell reports (12.02.2019)
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Parkinson's disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Yildirim-Balatan, Cansu, Fenyi, Alexis, Besnault, Pierre, Gomez, Lina, Sepulveda-Diaz, Julia E, Michel, Patrick P, Melki, Ronald, Hunot, Stéphane
Published in Journal of neuroinflammation (21.02.2024)
Published in Journal of neuroinflammation (21.02.2024)
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Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Fayard, Audrey, Fenyi, Alexis, Lavisse, Sonia, Dovero, Sandra, Bousset, Luc, Bellande, Tracy, Lecourtois, Sophie, Jouy, Christophe, Guillermier, Martine, Jan, Caroline, Gipchtein, Pauline, Dehay, Benjamin, Bezard, Erwan, Melki, Ronald, Hantraye, Philippe, Aron Badin, Romina
Published in Neurobiology of disease (01.05.2023)
Published in Neurobiology of disease (01.05.2023)
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Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease
Fenyi, Alexis, Duyckaerts, Charles, Bousset, Luc, Braak, Heiko, Del Tredici, Kelly, Melki, Ronald, On Behalf Of The Brainbank Neuro-Ceb Neuropathology Network
Published in Cells (Basel, Switzerland) (01.01.2021)
Published in Cells (Basel, Switzerland) (01.01.2021)
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Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
Walton, Sara, Fenyi, Alexis, Tittle, Tyler, Sidransky, Ellen, Pal, Gian, Choi, Solji, Melki, Ronald, Killinger, Bryan A, Kordower, Jeffrey H
Published in NPJ Parkinson's Disease (21.05.2024)
Published in NPJ Parkinson's Disease (21.05.2024)
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Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces
Fenyi, Alexis, Coens, Audrey, Bellande, Tracy, Melki, Ronald, Bousset, Luc
Published in Scientific reports (17.07.2018)
Published in Scientific reports (17.07.2018)
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Journal Article
Parkinson's disease-derived [alpha]-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Yildirim-Balatan, Cansu, Fenyi, Alexis, Besnault, Pierre, Gomez, Lina, Sepulveda-Diaz, Julia E, Michel, Patrick P, Melki, Ronald, Hunot, Stéphane
Published in Journal of neuroinflammation (21.02.2024)
Published in Journal of neuroinflammation (21.02.2024)
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Journal Article
The structural differences between patient-derived [alpha]-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies
Van der Perren, Anke, Gelders, Géraldine, Fenyi, Alexis, Bousset, Luc, Brito, Filipa, Peelaerts, Wouter, Van den Haute, Chris
Published in Acta neuropathologica (01.06.2020)
Published in Acta neuropathologica (01.06.2020)
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Journal Article
Detection of antibodies against the huntingtin protein in human plasma
Denis, Hélèna L., Alpaugh, Melanie, Alvarez, Claudia P., Fenyi, Alexis, Barker, Roger A., Chouinard, Sylvain, Arrowsmith, Cheryl H., Melki, Ronald, Labib, Richard, Harding, Rachel J., Cicchetti, Francesca
Published in Cellular and molecular life sciences : CMLS (01.02.2023)
Published in Cellular and molecular life sciences : CMLS (01.02.2023)
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α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
Piroska, Leonard, Fenyi, Alexis, Thomas, Scott, Plamont, Marie-Aude, Redeker, Virginie, Melki, Ronald, Gueroui, Zoher
Published in Science advances (18.08.2023)
Published in Science advances (18.08.2023)
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Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits
Negrini, Matilde, Tomasello, Giuseppe, Davidsson, Marcus, Fenyi, Alexis, Adant, Cécile, Hauser, Swantje, Espa, Elena, Gubinelli, Francesco, Manfredsson, Fredric P., Melki, Ronald, Heuer, Andreas
Published in Journal of Parkinson's disease (01.01.2022)
Published in Journal of Parkinson's disease (01.01.2022)
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Journal Article
Sequential or simultaneous injection of preformed fibrils and AAV overexpression of alpha-synuclein are equipotent in producing relevant pathology and behavioral deficits
Negrini, Matilde, Tomasello, Giuseppe, Davidsson, Marcus, Fenyi, Alexis, Adant, Cécile, Hauser, Swantje, Espa, Elena, Gubinelli, Francesco, Manfredsson, Fredric, Melki, Ronald, Heuer, Andreas
Published in Journal of Parkinson's disease (23.02.2022)
Published in Journal of Parkinson's disease (23.02.2022)
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Journal Article
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF
Audrain, Mickael, Egesipe, Anne-Laure, Tentillier, Noémie, Font, Laure, Ratnam, Monisha, Mottier, Lorene, Clavel, Mathieu, Le Roux-Bourdieu, Morgan, Fenyi, Alexis, Ollier, Romain, Chevalier, Elodie, Guilhot, Florence, Fuchs, Aline, Piorkowska, Kasia, Carlyle, Becky, Arnold, Steven E, Berry, James D, Luthi-Carter, Ruth, Adolfsson, Oskar, Pfeifer, Andrea, Kosco-Vilbois, Marie, Seredenina, Tamara, Afroz, Tariq
Published in Brain communications (01.11.2023)
Published in Brain communications (01.11.2023)
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