Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate
Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors
Watson, Nigel S., Brown, David, Campbell, Matthew, Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Fenwick, Rebecca, Hamblin, J. Nicole, Haslam, Claudine, Kelly, Henry A., King, N. Paul, Kurtis, Cynthia L., Leach, Andrew R., Manchee, Gary R., Mason, Andrew M., Mitchell, Charlotte, Patel, Champa, Patel, Vipulkumar K., Senger, Stefan, Shah, Gita P., Weston, Helen E., Whitworth, Caroline, Young, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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