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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
Pandit, Jayvardhan, Forman, Michael D, Fennell, Kimberly F, Dillman, Keith S, Menniti, Frank S
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2009)
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An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
Lees, Joshua A., Dias, João M., Rajamohan, Francis, Fortin, Jean-Philippe, O’Connor, Rebecca, Kong, Jimmy X., Hughes, Emily A. G., Fisher, Ethan L., Tuttle, Jamison B., Lovett, Gabrielle, Kormos, Bethany L., Unwalla, Rayomand J., Zhang, Lei, Dechert Schmitt, Anne-Marie, Zhou, Dahui, Moran, Michael, Stevens, Kimberly A., Fennell, Kimberly F., Varghese, Alison E., Maxwell, Andrew, Cote, Emmaline E., Zhang, Yuan, Han, Seungil
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Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, Varghese, Alison E.
Published in Journal of medicinal chemistry (12.01.2023)
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Machine Learning for Prioritization of Thermostabilizing Mutations for G-Protein Coupled Receptors
Muk, Sanychen, Ghosh, Soumadwip, Achuthan, Srisairam, Chen, Xiaomin, Yao, XiaoJie, Sandhu, Manbir, Griffor, Matthew C., Fennell, Kimberly F., Che, Ye, Shanmugasundaram, Veerabahu, Qiu, Xiayang, Tate, Christopher G., Vaidehi, Nagarajan
Published in Biophysical journal (03.12.2019)
Published in Biophysical journal (03.12.2019)
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Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
Butler, Christopher R., Beck, Elizabeth M., Harris, Anthony, Huang, Zhen, McAllister, Laura A., am Ende, Christopher W., Fennell, Kimberly, Foley, Timothy L., Fonseca, Kari, Hawrylik, Steven J., Johnson, Douglas S., Knafels, John D., Mente, Scot, Noell, G. Stephen, Pandit, Jayvardhan, Phillips, Tracy B., Piro, Justin R., Rogers, Bruce N., Samad, Tarek A., Wang, Jane, Wan, Shuangyi, Brodney, Michael A.
Published in Journal of medicinal chemistry (14.12.2017)
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Structural basis of the acyl-transfer mechanism of human GPAT1
Johnson, Zachary Lee, Ammirati, Mark, Wasilko, David Jonathan, Chang, Jeanne S., Noell, Stephen, Foley, Timothy L., Yoon, Hyejin, Smith, Kathleen, Asano, Shoh, Hales, Katherine, Wan, Min, Yang, Qingyi, Piotrowski, Mary A., Farley, Kathleen A., Gilbert, Tamara, Aschenbrenner, Lisa M., Fennell, Kimberly F., Dutra, Jason K., Xu, Mary, Guo, Chunyang, Varghese, Alison E., Bellenger, Justin, Quinn, Alandra, am Ende, Christopher W., West, Graham M., Griffor, Matthew C., Bennett, Donald, Calabrese, Matthew, Steppan, Claire M., Han, Seungil, Wu, Huixian
Published in Nature structural & molecular biology (01.01.2023)
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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist
Schnute, Mark E, Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R, Bolten, Charles W, Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P, Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F, Fish, Susan, Flick, Andrew C, Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K, Heasley, Steven E, Hegen, Martin, Hromockyj, Alexander E, Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R, Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G, Kyne, Jr, Robert E, Li, Wei, Löfstedt, Joakim, Long, Scott A, Menard, Carol A, Mente, Scot, Messing, Dean, Meyers, Marvin J, Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J, Prinsen, Michael J, Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P, Thorarensen, Atli, Trujillo, John I, Trzupek, John D, Unwalla, Ray, Vajdos, Felix F, Weinberg, Robin A, Wood, David C, Xing, Li, Zamaratski, Edouard, Zapf, Christoph W, Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel
Published in Journal of medicinal chemistry (13.12.2018)
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Discovery and structural characterization of an allosteric inhibitor of bacterial cis‐prenyltransferase
Danley, Dennis E., Baima, Eric T., Mansour, Mahmoud, Fennell, Kimberly F., Chrunyk, Boris A., Mueller, John P., Liu, Shenping, Qiu, Xiayang
Published in Protein science (01.01.2015)
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Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia
Helal, Christopher J, Kang, Zhijun, Hou, Xinjun, Pandit, Jayvardhan, Chappie, Thomas A, Humphrey, John M, Marr, Eric S, Fennell, Kimberly F, Chenard, Lois K, Fox, Carol, Schmidt, Christopher J, Williams, Robert D, Chapin, Douglas S, Siuciak, Judith, Lebel, Lorraine, Menniti, Frank, Cianfrogna, Julia, Fonseca, Kari R, Nelson, Frederick R, O’Connor, Rebecca, MacDougall, Mary, McDowell, Laura, Liras, Spiros
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Published in Journal of medicinal chemistry (14.07.2011)
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Discovery of 3‑Cyano‑N‑(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)‑1H‑pyrrolo[2,3‑b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist
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Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
Ahn, Kay, Boehm, Markus, Brown, Matthew F, Calloway, Jessica, Che, Ye, Chen, Jinshan, Fennell, Kimberly F, Geoghegan, Kieran F, Gilbert, Adam M, Gutierrez, Jemy A, Kalgutkar, Amit S, Lanba, Adhiraj, Limberakis, Chris, Magee, Thomas V, O’Doherty, Inish, Oliver, Robert, Pabst, Brandon, Pandit, Jayvardhan, Parris, Kevin, Pfefferkorn, Jeffrey A, Rolph, Timothy P, Patel, Rushi, Schuff, Brandon, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Varghese, Alison H, Vera, Nicholas B, Vernochet, Cecile, Yan, Jiangli
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, LaChapelle, Erik A, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants
Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
Pandit, Jayvardhan, Forman, Michael D., Fennell, Kimberly F., Dillman, Keith S., Menniti, Frank S.
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2015)
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Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yObenzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor Related Orphan Receptor C2 Inverse Agonist
Schnute, Mark E., Wennerstal, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R., Bolten, Charles W., Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P., Crouse, Kimberly, Farnegardh, Mathias, Fennell, Kimberly F., Fish, Susan, Flick, Andrew C., Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K., Heasley, Steven E., Hegen, Martin, Hromockyj, Alexander E., Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Bjorn, Kiefer, James R., Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G., Kyne, Robert E., Li, Wei, Lofstedt, Joakim, Long, Scott A., Menard, Carol A., Mente, Scot, Messing, Dean, Meyers, Marvin J., Napierata, Lee, Noteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J., Prinsen, Michael J., Rhonnstad, Patrik, Backstrom-Rydin, Eva, Sandberg, Johnny, Sandstrom, Maria, Shah, Falgun, Sjoberg, Maria, Sundell, Aron, Taylor, Alexandria P., Thorarensen, Atli, Trujillo, John I., Trzupek, John D., Unwalla, Ray, Vajdos, Felix F., Weinberg, Robin A., Wood, David C., Xing, Li, Zamaratski, Edouard, Zapf, Christoph W., Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Discovery and structural characterization of an allosteric inhibitor of bacterial c is ‐prenyltransferase
Danley, Dennis E., Baima, Eric T., Mansour, Mahmoud, Fennell, Kimberly F., Chrunyk, Boris A., Mueller, John P., Liu, Shenping, Qiu, Xiayang
Published in Protein science (01.01.2015)
Published in Protein science (01.01.2015)
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Activation of Human Liver Glycogen Phosphorylase by Alteration of the Secondary Structure and Packing of the Catalytic Core
Rath, Virginia L., Ammirati, Mark, LeMotte, Peter K., Fennell, Kimberly F., Mansour, Mahmoud N., Danley, Dennis E., Hynes, Thomas R., Schulte, Gayle K., Wasilko, David J., Pandit, Jayvardhan
Published in Molecular cell (2000)
Published in Molecular cell (2000)
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New kinase regulation mechanism found in HipBA: a bacterial persistence switch
Evdokimov, Artem, Voznesensky, Igor, Fennell, Kimberly, Anderson, Marie, Smith, James F., Fisher, Douglas A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2009)
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2009)
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