Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
Smith, Mark E. B, Schumacher, Felix F, Ryan, Chris P, Tedaldi, Lauren M, Papaioannou, Danai, Waksman, Gabriel, Caddick, Stephen, Baker, James R
Published in Journal of the American Chemical Society (17.02.2010)
Published in Journal of the American Chemical Society (17.02.2010)
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Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents
Jones, Mathew W, Strickland, Rachel A, Schumacher, Felix F, Caddick, Stephen, Baker, James. R, Gibson, Matthew I, Haddleton, David M
Published in Journal of the American Chemical Society (25.01.2012)
Published in Journal of the American Chemical Society (25.01.2012)
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Journal Article
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis
Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (21.05.2011)
Published in Chemical communications (Cambridge, England) (21.05.2011)
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Journal Article
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation
Castaneda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (01.01.2013)
Published in Chemical communications (Cambridge, England) (01.01.2013)
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Journal Article
Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging
Schumacher, Felix F., Nunes, Joao P. M., Maruani, Antoine, Chudasama, Vijay, Smith, Mark E. B., Chester, Kerry A., Baker, James R., Caddick, Stephen
Published in Organic & biomolecular chemistry (07.10.2014)
Published in Organic & biomolecular chemistry (07.10.2014)
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Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties
Sela, Tatjana, Mansø, Mads, Siegel, Michel, Marban-Doran, Céline, Ducret, Axel, Niewöhner, Jens, Ravn, Jacob, Martin, Rainer E., Sommer, Annika, Lohmann, Sabine, Krippendorff, Ben-Fillippo, Ladefoged, Mette, Indlekofer, Annette, Quaiser, Tom, Bueddefeld, Florian, Koller, Erich, Mohamed, Mohamed Y., Oelschlaegel, Tobias, Gothelf, Kurt V., Hofer, Kerstin, Schumacher, Felix F.
Published in Bioconjugate chemistry (15.11.2023)
Published in Bioconjugate chemistry (15.11.2023)
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Journal Article
Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides
Jones, Mathew W, Strickland, Rachel A, Schumacher, Felix F, Caddick, Stephen, Baker, James R, Gibson, Matthew I, Haddleton, David M
Published in Chemical communications (Cambridge, England) (28.04.2012)
Published in Chemical communications (Cambridge, England) (28.04.2012)
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Journal Article
Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'
Schumacher, Felix F, Sanchania, Vishal A, Tolner, Berend, Wright, Zoë V F, Ryan, Chris P, Smith, Mark E B, Ward, John M, Caddick, Stephen, Kay, Christopher W M, Aeppli, Gabriel, Chester, Kerry A, Baker, James R
Published in Scientific reports (22.03.2013)
Published in Scientific reports (22.03.2013)
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Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration
Nan, Ruodan, Farabella, Irene, Schumacher, Felix F., Miller, Ami, Gor, Jayesh, Martin, Andrew C.R., Jones, David T., Lengyel, Imre, Perkins, Stephen J.
Published in Journal of molecular biology (13.05.2011)
Published in Journal of molecular biology (13.05.2011)
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Journal Article
In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
Schumacher, Felix F, Nobles, Muriel, Ryan, Chris P, Smith, Mark E. B, Tinker, Andrew, Caddick, Stephen, Baker, James R
Published in Bioconjugate chemistry (16.02.2011)
Published in Bioconjugate chemistry (16.02.2011)
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Journal Article
Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridgingElectronic supplementary information (ESI) available: Synthetic procedures, 1H and 13C NMR spectra for synthesised compounds, additional SDS-PAGE gels, LCMS chromatograms, Ellman's analysis and other supplementary results. See DOI: 10.1039/c4ob01550a
Schumacher, Felix F, Nunes, João P. M, Maruani, Antoine, Chudasama, Vijay, Smith, Mark E. B, Chester, Kerry A, Baker, James R, Caddick, Stephen
Year of Publication 27.08.2014
Year of Publication 27.08.2014
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Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging† †Electronic supplementary information (ESI) available: Synthetic procedures, 1H and 13C NMR spectra for synthesised compounds, additional SDS-PAGE gels, LCMS chromatograms, Ellman's analysis and other supplementary results. See DOI: 10.1039/c4ob01550a Click here for additional data file
Schumacher, Felix F., Nunes, João P. M., Maruani, Antoine, Chudasama, Vijay, Smith, Mark E. B., Chester, Kerry A., Baker, James R., Caddick, Stephen
Published in Organic & biomolecular chemistry (08.08.2014)
Published in Organic & biomolecular chemistry (08.08.2014)
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Journal Article
Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all novel compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3cc45220dClick here for additional data file
Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (21.06.2013)
Published in Chemical communications (Cambridge, England) (21.06.2013)
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Journal Article
Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c2cc30259d
Jones, Mathew W, Strickland, Rachel A, Schumacher, Felix F, Caddick, Stephen, Baker, James. R, Gibson, Matthew I, Haddleton, David M
Year of Publication 28.03.2012
Year of Publication 28.03.2012
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Journal Article
Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file
Chudasama, Vijay, Smith, Mark E. B., Schumacher, Felix F., Papaioannou, Danai, Waksman, Gabriel, Baker, James R., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (07.07.2011)
Published in Chemical communications (Cambridge, England) (07.07.2011)
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Journal Article
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k Click here for additional data file
Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (05.04.2011)
Published in Chemical communications (Cambridge, England) (05.04.2011)
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