Activation and allosteric modulation of a muscarinic acetylcholine receptor
Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.
Published in Nature (London) (05.12.2013)
Published in Nature (London) (05.12.2013)
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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
Thal, David M., Sun, Bingfa, Feng, Dan, Nawaratne, Vindhya, Leach, Katie, Felder, Christian C., Bures, Mark G., Evans, David A., Weis, William I., Bachhawat, Priti, Kobilka, Tong Sun, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur
Published in Nature (London) (17.03.2016)
Published in Nature (London) (17.03.2016)
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The Opioid Crisis and the Future of Addiction and Pain Therapeutics
Coussens, Nathan P, Sittampalam, G Sitta, Jonson, Samantha G, Hall, Matthew D, Gorby, Heather E, Tamiz, Amir P, McManus, Owen B, Felder, Christian C, Rasmussen, Kurt
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
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Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects
Valant, Celine, Felder, Christian C, Sexton, Patrick M, Christopoulos, Arthur
Published in Molecular pharmacology (01.01.2012)
Published in Molecular pharmacology (01.01.2012)
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Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
Shekhar, Anantha, Potter, William Z., Lightfoot, Jeffrey, Lienemann, John, Dubé, Sanjay, Mallinckrodt, Craig, Bymaster, Frank P., McKinzie, David L., Felder, Christian C.
Published in The American journal of psychiatry (01.08.2008)
Published in The American journal of psychiatry (01.08.2008)
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
Dennis, Siobhan H, Pasqui, Francesca, Colvin, Ellen M, Sanger, Helen, Mogg, Adrian J, Felder, Christian C, Broad, Lisa M, Fitzjohn, Steve M, Isaac, John T R, Mellor, Jack R
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2016)
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2016)
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Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
Published in Nature communications (23.07.2019)
Published in Nature communications (23.07.2019)
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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Burger, Wessel A. C., Pham, Vi, Vuckovic, Ziva, Powers, Alexander S., Mobbs, Jesse I., Laloudakis, Yianni, Glukhova, Alisa, Wootten, Denise, Tobin, Andrew B., Sexton, Patrick M., Paul, Steven M., Felder, Christian C., Danev, Radostin, Dror, Ron O., Christopoulos, Arthur, Valant, Celine, Thal, David M.
Published in Nature communications (06.09.2023)
Published in Nature communications (06.09.2023)
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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
Bradley, Sophie J, Bourgognon, Julie-Myrtille, Sanger, Helen E, Verity, Nicholas, Mogg, Adrian J, White, David J, Butcher, Adrian J, Moreno, Julie A, Molloy, Colin, Macedo-Hatch, Timothy, Edwards, Jennifer M, Wess, Jurgen, Pawlak, Robert, Read, David J, Sexton, Patrick M, Broad, Lisa M, Steinert, Joern R, Mallucci, Giovanna R, Christopoulos, Arthur, Felder, Christian C, Tobin, Andrew B
Published in The Journal of clinical investigation (01.02.2017)
Published in The Journal of clinical investigation (01.02.2017)
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New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)
Nawaratne, Vindhya, Leach, Katie, Suratman, Nur, Loiacono, Richard E, Felder, Christian C, Armbruster, Blaine N, Roth, Bryan L, Sexton, Patrick M, Christopoulos, Arthur
Published in Molecular pharmacology (01.10.2008)
Published in Molecular pharmacology (01.10.2008)
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Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice
Martin, Anna E, Schober, Douglas A, Nikolayev, Alexander, Tolstikov, Vladimir V, Anderson, Wesley H, Higgs, Richard E, Kuo, Ming-Shang, Laksmanan, Anastasia, Catlow, John T, Li, Xia, Felder, Christian C, Witkin, Jeffrey M
Published in CNS & neurological disorders drug targets (01.01.2017)
Published in CNS & neurological disorders drug targets (01.01.2017)
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Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor
Porter, Amy C, Sauer, John-Michael, Knierman, Michael D, Becker, Gerald W, Berna, Michael J, Bao, Jingqi, Nomikos, George G, Carter, Petra, Bymaster, Frank P, Leese, Andrea Baker, Felder, Christian C
Published in The Journal of pharmacology and experimental therapeutics (01.06.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2002)
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Characterization of PCS1055, a novel muscarinic M4 receptor antagonist
Croy, Carrie H., Chan, Wai Y., Castetter, Andrea M., Watt, Marla L., Quets, Anne T., Felder, Christian C.
Published in European journal of pharmacology (05.07.2016)
Published in European journal of pharmacology (05.07.2016)
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Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor
Buckley, Nancy E, McCoy, Kathleen L, Mezey, Éva, Bonner, Tom, Zimmer, Anne, Felder, Christian C, Glass, Michelle, Zimmer, Andreas
Published in European journal of pharmacology (19.05.2000)
Published in European journal of pharmacology (19.05.2000)
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Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates
Andersen, Maibritt B, Croy, Carrie Hughes, Dencker, Ditte, Werge, Thomas, Bymaster, Frank P, Felder, Christian C, Fink-Jensen, Anders
Published in PloS one (16.04.2015)
Published in PloS one (16.04.2015)
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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Wess, Jürgen, Yamada, Masahisa, Miyakawa, Tsuyoshi, Duttaroy, Alokesh, Yamanaka, Akihiro, Moriguchi, Toru, Makita, Ryosuke, Ogawa, Masaharu, Chou, Chieh J, Xia, Bing, Crawley, Jacqueline N, Felder, Christian C, Deng, Chu-Xia
Published in Nature (London) (08.03.2001)
Published in Nature (London) (08.03.2001)
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