Safety, tolerability, pharmacokinetics and pharmacodynamics of the anti‐CD38 cytolytic antibody TAK‐079 in healthy subjects
Fedyk, Eric R., Zhao, Lin, Koch, Annelize, Smithson, Glennda, Estevam, Jose, Chen, Grace, Lahu, Gezim, Roepcke, Stefan, Lin, Jianchang, Mclean, Lachy
Published in British journal of clinical pharmacology (01.07.2020)
Published in British journal of clinical pharmacology (01.07.2020)
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A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects
Esfandiari, Ehsanollah, Chen, Mary, Smithson, Glennda, Blair, Derek, Faessel, Helene, Wagner, John, Mclean, Lachy, Fedyk, Eric R.
Published in Clinical and translational science (01.05.2021)
Published in Clinical and translational science (01.05.2021)
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A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys
Korver, Wouter, Carsillo, Mary, Yuan, Josh, Idamakanti, Neeraja, Wagoner, Matthew, Shi, Pu, Xia, Cindy Q, Smithson, Glennda, McLean, Lachy, Zalevsky, Jonathan, Fedyk, Eric R
Published in The Journal of pharmacology and experimental therapeutics (01.08.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2019)
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Antagonizing the α4β1 integrin, but not α4β7, inhibits leukocytic infiltration of the central nervous system in rhesus monkey experimental autoimmune encephalomyelitis
Haanstra, Krista G, Hofman, Sam O, Lopes Estêvão, Dave M, Blezer, Erwin L A, Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A, Fedyk, Eric R
Published in The Journal of immunology (1950) (01.03.2013)
Published in The Journal of immunology (1950) (01.03.2013)
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Journal Article
Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial
Roepcke, Stefan, Plock, Nele, Yuan, Josh, Fedyk, Eric R., Lahu, Gezim, Zhao, Lin, Smithson, Glennda
Published in Pharmacology research & perspectives (01.06.2018)
Published in Pharmacology research & perspectives (01.06.2018)
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Journal Article
Pharmacokinetics and pharmacodynamics of the cytolytic anti‐ CD 38 human monoclonal antibody TAK ‐079 in monkey – model assisted preparation for the first in human trial
Roepcke, Stefan, Plock, Nele, Yuan, Josh, Fedyk, Eric R., Lahu, Gezim, Zhao, Lin, Smithson, Glennda
Published in Pharmacology research & perspectives (01.06.2018)
Published in Pharmacology research & perspectives (01.06.2018)
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Journal Article
Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro
Csizmadia, Vilmos, Raczynski, Arek, Csizmadia, Eva, Fedyk, Eric R., Rottman, James, Alden, Carl L.
Published in Neurotoxicology (Park Forest South) (01.03.2008)
Published in Neurotoxicology (Park Forest South) (01.03.2008)
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Journal Article
Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation
Lippert, Eric, Yowe, David L, Gonzalo, Jose-Angel, Justice, J. Paul, Webster, Jeremy M, Fedyk, Eric R, Hodge, Martin, Miller, Cheryl, Gutierrez-Ramos, Jose-Carlos, Borrego, Francisco, Keane-Myers, Andrea, Druey, Kirk M
Published in The Journal of immunology (1950) (01.08.2003)
Published in The Journal of immunology (1950) (01.08.2003)
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Journal Article
Correlation of serpin–protease expression by comparative analysis of real-time PCR profiling data
Badola, Sunita, Spurling, Heidi, Robison, Keith, Fedyk, Eric R., Silverman, Gary A., Strayle, Jochen, Kapeller, Rosana, Tsu, Christopher A.
Published in Genomics (San Diego, Calif.) (01.08.2006)
Published in Genomics (San Diego, Calif.) (01.08.2006)
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Journal Article
Exclusive antagonism of the α4β7 integrin by vedolizumab confirms the gut‐selectivity of this pathway in primates
Fedyk, Eric R., Wyant, Tim, Yang, Li‐Li, Csizmadia, Vilmos, Burke, Kristine, Yang, Hua, Kadambi, Vivek J.
Published in Inflammatory bowel diseases (01.11.2012)
Published in Inflammatory bowel diseases (01.11.2012)
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Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)
Liu, Fang, Gonzalo, Jose Angel, Manning, Stephen, O’Connell, Laura E., Fedyk, Eric R., Burke, Kristine E., Elder, Amy M., Pulido, Jacqueline C., Cao, Wei, Tayber, Olga, Qiu, Yubin, Ghosh, Shomir, Ocain, Timothy D., Hodge, Martin R., Suzuki-Yagawa, Yuriko
Published in Prostaglandins & other lipid mediators (01.05.2005)
Published in Prostaglandins & other lipid mediators (01.05.2005)
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IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2
Smith, R S, Fedyk, E R, Springer, T A, Mukaida, N, Iglewski, B H, Phipps, R P
Published in The Journal of immunology (1950) (01.07.2001)
Published in The Journal of immunology (1950) (01.07.2001)
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Journal Article
Exclusive antagonism of the [alpha]4[beta]7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates
Fedyk, Eric R, Wyant, Tim, Yang, Li-Li, Csizmadia, Vilmos, Burke, Kristine, Yang, Hua, Kadambi, Vivek J
Published in Inflammatory bowel diseases (01.11.2012)
Published in Inflammatory bowel diseases (01.11.2012)
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Journal Article
Antagonizing the alpha 4 beta 1 Integrin, but Not alpha 4 beta 7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis
Haanstra, Krista G, Hofman, Sam O, Lopes Estevao, Dave M, Blezer, Erwin LA, Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A, Fedyk, Eric R
Published in The Journal of immunology (1950) (01.03.2013)
Published in The Journal of immunology (1950) (01.03.2013)
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Journal Article
The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α4β7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
Dulce Soler, Tobias Chapman, Li-Li Yang, Tim Wyant, Robert Egan, Eric R. Fedyk
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Journal Article
The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α 4 β 7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
Soler, Dulce, Chapman, Tobias, Yang, Li-Li, Wyant, Tim, Egan, Robert, Fedyk, Eric R.
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Journal Article
Prostaglandin E$_{2}$ Receptors of the EP$_{2}$ and EP$_{4}$ Subtypes Regulate Activation and Differentiation of Mouse B Lymphocytes to IgE-Secreting Cells
Fedyk, Eric R., Phipps, Richard P.
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1996)
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