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Long‐term safety and sustained efficacy for up to 5 years of treatment with recombinant factor IX Fc fusion protein in subjects with haemophilia B: Results from the B‐YOND extension study
Pasi, K. John, Fischer, Kathelijn, Ragni, Margaret, Kulkarni, Roshni, Ozelo, Margareth C., Mahlangu, Johnny, Shapiro, Amy, P’Ng, Stephanie, Chambost, Hervé, Nolan, Beatrice, Bennett, Carolyn, Matsushita, Tadashi, Winding, Bent, Fruebis, Joachim, Yuan, Huixing, Rudin, Dan, Oldenburg, Johannes
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2020)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2020)
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Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A
Young, G., Mahlangu, J., Kulkarni, R., Nolan, B., Liesner, R., Pasi, J., Barnes, C., Neelakantan, S., Gambino, G., Cristiano, L. M., Pierce, G. F., Allen, G.
Published in Journal of thrombosis and haemostasis (01.06.2015)
Published in Journal of thrombosis and haemostasis (01.06.2015)
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Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Mahlangu, Johnny, Powell, Jerry S., Ragni, Margaret V., Chowdary, Pratima, Josephson, Neil C., Pabinger, Ingrid, Hanabusa, Hideji, Gupta, Naresh, Kulkarni, Roshni, Fogarty, Patrick, Perry, David, Shapiro, Amy, Pasi, K. John, Apte, Shashikant, Nestorov, Ivan, Jiang, Haiyan, Li, Shuanglian, Neelakantan, Srividya, Cristiano, Lynda M., Goyal, Jaya, Sommer, Jurg M., Dumont, Jennifer A., Dodd, Nigel, Nugent, Karen, Vigliani, Gloria, Luk, Alvin, Brennan, Aoife, Pierce, Glenn F.
Published in Blood (16.01.2014)
Published in Blood (16.01.2014)
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Long‐acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B‐LONG study
Powell, Jerry S., Apte, Shashikant, Chambost, Hervé, Hermans, Cedric, Jackson, Shannon, Josephson, Neil C., Mahlangu, Johnny N., Ozelo, Margareth C., Peerlinck, Kathelijne, Pasi, John, Perry, David, Ragni, Margaret V., Wang, Xuefeng, Jiang, Haiyan, Li, Shuanglian, Cristiano, Lynda M., Innes, Alison, Nugent, Karen, Brennan, Aoife, Luk, Alvin, Allen, Geoffrey, Pierce, Glenn F., Robinson, Brian
Published in British journal of haematology (01.01.2015)
Published in British journal of haematology (01.01.2015)
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Long-term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A
Nolan, B., Mahlangu, J., Perry, D., Young, G., Liesner, R., Konkle, B., Rangarajan, S., Brown, S., Hanabusa, H., Pasi, K. J., Pabinger, I., Jackson, S., Cristiano, L. M., Li, X., Pierce, G. F., Allen, G.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2016)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2016)
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Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients
Powell, Jerry S., Josephson, Neil C., Quon, Doris, Ragni, Margaret V., Cheng, Gregory, Li, Ella, Jiang, Haiyan, Li, Lian, Dumont, Jennifer A., Goyal, Jaya, Zhang, Xin, Sommer, Jurg, McCue, Justin, Barbetti, Margaret, Luk, Alvin, Pierce, Glenn F.
Published in Blood (29.03.2012)
Published in Blood (29.03.2012)
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Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension study
Nolan, Beatrice, Mahlangu, Johnny, Pabinger, Ingrid, Young, Guy, Konkle, Barbara A., Barnes, Chris, Nogami, Keiji, Santagostino, Elena, Pasi, K. John, Khoo, Liane, Winding, Bent, Yuan, Huixing, Fruebis, Joachim, Rudin, Dan, Oldenburg, Johannes
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2020)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2020)
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Pharmacokinetic parameters of recombinant factor IX Fc fusion protein are not influenced by factor IX antigen levels in subjects from the Phase 3 B‐LONG trial
Sidonio, Robert F., Casiano, Sandra, Falk, Aletta, Altincatal, Arman, Katragadda, Suresh, Santagostino, Elena, Windyga, Jerzy
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2023)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2023)
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Treatment of bleeding episodes with recombinant factor VIII Fc fusion protein in A‐LONG study subjects with severe haemophilia A
Shapiro, A. D., Mahlangu, J. N., Perry, D., Pasi, J., Quon, D. V., Chowdary, P., Tsao, E., Li, S., Innes, A., Pierce, G. F., Allen, G. A.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2017)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.05.2017)
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Recombinant factor VIII Fc fusion protein: extended‐interval dosing maintains low bleeding rates and correlates with von Willebrand factor levels
Shapiro, A. D., Ragni, M. V., Kulkarni, R., Oldenberg, J., Srivastava, A., Quon, D. V., Pasi, K. J., Hanabusa, H., Pabinger, I., Mahlangu, J., Fogarty, P., Lillicrap, D., Kulke, S., Potts, J., Neelakantan, S., Nestorov, I., Li, S., Dumont, J. A., Jiang, H., Brennan, A., Pierce, G. F.
Published in Journal of thrombosis and haemostasis (01.11.2014)
Published in Journal of thrombosis and haemostasis (01.11.2014)
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Safety, pharmacokinetics, and pharmacodynamics of TG103, a novel long-acting GLP-1/Fc fusion protein after a single ascending dose in Chinese healthy subjects
Jin, Jiangli, Cui, Gang, Mi, Na, Wu, Wei, Zhang, Xin, Xiao, Chunyan, Wang, Jing, Qiu, Xueying, Han, Mai, Li, Ziyan, Wang, Lei, Lu, Tong, Niu, Huikun, Wu, Zhaoxi, Li, Jintong
Published in European journal of pharmaceutical sciences (01.06.2023)
Published in European journal of pharmaceutical sciences (01.06.2023)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of YH35324, a Novel Long-Acting High-Affinity IgETrap-Fc Fusion Protein, in Atopic Subjects with a Total IgE > 700 IU/mL
Ye, Young-Min, Park, Jung-Won, Kim, Sae-Hoon, Cho, Yoo Sook, Lee, Sook Young, Lee, Sae Young, Sim, Sujin, Song, Eunji, Kim, Bomin, Lee, Jieon, Kim, Su Kyung, Jang, Myoung Ho, Park, Hae-Sim
Published in Journal of allergy and clinical immunology (01.02.2024)
Published in Journal of allergy and clinical immunology (01.02.2024)
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Prophylaxis with recombinant factor IX Fc fusion protein reduces the risk of bleeding and delays time to first spontaneous bleed event in previously untreated patients with haemophilia B: A post hoc analysis of the PUPs B‐LONG study
Nolan, Beatrice, Recht, Michael, Rendo, Pablo, Falk, Aletta, Foster, Meredith, Casiano, Sandra, Rauch, Antoine, Shapiro, Amy
Published in European journal of haematology (01.10.2024)
Published in European journal of haematology (01.10.2024)
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Long-acting recombinant factor VIII Fc fusion protein (rFVIIIFc) for perioperative haemostatic management in severe haemophilia A
Mahlangu, Johnny N, Ragni, Margaret, Gupta, Naresh, Rangarajan, Savita, Klamroth, Robert, Oldenburg, Johannes, Nogami, Keiji, Young, Guy, Cristiano, Lynda M, Dong, Yingwen, Allen, Geoffrey, Pierce, Glenn F, Robinson, Brian
Published in Thrombosis and haemostasis (04.07.2016)
Published in Thrombosis and haemostasis (04.07.2016)
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Improved joint health in subjects with severe haemophilia A treated prophylactically with recombinant factor VIII Fc fusion protein
Oldenburg, J., Kulkarni, R., Srivastava, A., Mahlangu, J. N., Blanchette, V. S., Tsao, E., Winding, B., Dumont, J., Jain, N.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2018)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.01.2018)
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Matching-Adjusted Indirect Comparison of Recombinant Factor IX Albumin Fusion Protein Versus Recombinant Factor IX Fc Fusion Protein for Weekly Prophylactic Treatment of Hemophilia B
Guillet, Benoit, Yan, Songkai, Hooper, Becky, Drelich, Douglass, Steenkamp, Jason, Tomic, Radovan, Mancuso, Maria Elisa
Published in Advances in therapy (01.02.2024)
Published in Advances in therapy (01.02.2024)
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Pharmacokinetics, Safety and Preliminary Efficacy of Multiple Doses of Pegylated Recombinant Human Coagulation Factor VIII-Fc Fusion Protein (FRSW117) in Previously Treated Adult and Adolescent Subjects with Severe Hemophilia a: Results from an Open-Label, Multicenter, Phase 2 Study
Xue, Feng, Chen, Weizhi, Guo, Shuxia, Hua, Haiying, Cao, Yu, Feng, Xianqi, Yang, Renchi
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients
Shapiro, Amy D., Ragni, Margaret V., Valentino, Leonard A., Key, Nigel S., Josephson, Neil C., Powell, Jerry S., Cheng, Gregory, Thompson, Arthur R., Goyal, Jaya, Tubridy, Karen L., Peters, Robert T., Dumont, Jennifer A., Euwart, Donald, Li, Lian, Hallén, Bengt, Gozzi, Peter, Bitonti, Alan J., Jiang, Haiyan, Luk, Alvin, Pierce, Glenn F.
Published in Blood (19.01.2012)
Published in Blood (19.01.2012)
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GS-3583, a novel FLT3 agonist Fc fusion protein, to expand conventional dendritic cells in healthy volunteers
Rajakumaraswamy, Nishanthan, Dauki, Anees, Kuhne, Michelle R., Trowe, Torsten, He, Jing, Clarke, Christopher, Carr, Brian, Worth, Angela, Vashishtha, Anshu, Schwabe, Christian, Othman, Ahmed A.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B
Pasi, K John, Fischer, Kathelijn, Ragni, Margaret, Nolan, Beatrice, Perry, David J, Kulkarni, Roshni, Ozelo, Margareth, Mahlangu, Johnny, Shapiro, Amy D, Baker, Ross I, Bennett, Carolyn M, Barnes, Christopher, Oldenburg, Johannes, Matsushita, Tadashi, Yuan, Huixing, Ramirez-Santiago, Alejandra, Pierce, Glenn F, Allen, Geoffrey, Mei, Baisong
Published in Thrombosis and haemostasis (2017)
Published in Thrombosis and haemostasis (2017)
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