Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer
Lainé, Muriel, Fanning, Sean W, Chang, Ya-Fang, Green, Bradley, Greene, Marianne E, Komm, Barry, Kurleto, Justyna D, Phung, Linda, Greene, Geoffrey L
Published in Breast cancer research : BCR (12.05.2021)
Published in Breast cancer research : BCR (12.05.2021)
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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation
Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L
Published in eLife (02.02.2016)
Published in eLife (02.02.2016)
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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Published in eLife (29.11.2018)
Published in eLife (29.11.2018)
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Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells
Safi, Rachid, Wardell, Suzanne E., Watkinson, Paige, Qin, Xiaodi, Lee, Marissa, Park, Sunghee, Krebs, Taylor, Dolan, Emma L., Blattler, Adam, Tsuji, Toshiya, Nayak, Surendra, Khater, Marwa, Fontanillo, Celia, Newlin, Madeline A., Kirkland, Megan L., Xie, Yingtian, Long, Henry, Fink, Emma C., Fanning, Sean W., Runyon, Scott, Brown, Myles, Xu, Shuichan, Owzar, Kouros, Norris, John D., McDonnell, Donald P.
Published in Nature communications (03.09.2024)
Published in Nature communications (03.09.2024)
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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells
Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Suavage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Nduwke, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W
Published in eLife (16.05.2022)
Published in eLife (16.05.2022)
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Editorial: Hormone resistance in cancer
Phoenix, John T., Budreika, Audris, Kostlan, Raymond J., Hwang, Justin H., Fanning, Sean W., Kregel, Steven
Published in Frontiers in endocrinology (Lausanne) (24.08.2023)
Published in Frontiers in endocrinology (Lausanne) (24.08.2023)
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Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies
Hancock, Govinda R, Gertz, Jason, Jeselsohn, Rinath, Fanning, Sean W
Published in Endocrinology (Philadelphia) (29.04.2024)
Published in Endocrinology (Philadelphia) (29.04.2024)
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Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer
Maximov, Philipp Y., Abderrahman, Balkees, Fanning, Sean W., Sengupta, Surojeet, Fan, Ping, Curpan, Ramona F., Rincon, Daniela Maria Quintana, Greenland, Jeffery A., Rajan, Shyamala S., Greene, Geoffrey L., Jordan, V. Craig
Published in Molecular pharmacology (01.08.2018)
Published in Molecular pharmacology (01.08.2018)
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Stapled Peptides with [gamma]-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction
Speltz, Thomas E, Fanning, Sean W, Mayne, Christopher G, Fowler, Colin, Tajkhorshid, Emad, Greene, Geoffrey L, Moore, Terry W
Published in Angewandte Chemie International Edition (18.03.2016)
Published in Angewandte Chemie International Edition (18.03.2016)
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Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction
Speltz, Thomas E., Fanning, Sean W., Mayne, Christopher G., Fowler, Colin, Tajkhorshid, Emad, Greene, Geoffrey L., Moore, Terry W.
Published in Angewandte Chemie (International ed.) (18.03.2016)
Published in Angewandte Chemie (International ed.) (18.03.2016)
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Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains
Speltz, Thomas E., Qiao, Zeyu, Swenson, Colin S., Shangguan, Xianghang, Coukos, John S., Lee, Christopher W., Thomas, Deborah M., Santana, Jesse, Fanning, Sean W., Greene, Geoffrey L., Moellering, Raymond E.
Published in Nature biotechnology (01.04.2023)
Published in Nature biotechnology (01.04.2023)
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Versatile Peptide Macrocyclization with Diels–Alder Cycloadditions
Montgomery, Jeffrey E, Donnelly, Justin A, Fanning, Sean W, Speltz, Thomas E, Shangguan, Xianghang, Coukos, John S, Greene, Geoffrey L, Moellering, Raymond E
Published in Journal of the American Chemical Society (16.10.2019)
Published in Journal of the American Chemical Society (16.10.2019)
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Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line
Ren, Pin, Tiede, Christian, Fanning, Sean W, Adams, Thomas, Speirs, Valerie, Nelson, Erik R, Cheng, Changfeng, Moore, Terry W, Greene, Geoffrey L, Tomlinson, Darren, Selvin, Paul R
Published in Biophysical journal (04.10.2022)
Published in Biophysical journal (04.10.2022)
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Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells
Vidana Gamage, Hashni Epa, Albright, Samuel T., Smith, Amanda J., Farmer, Rachel, Shahoei, Sayyed Hamed, Wang, Yu, Fink, Emma C., Jacquin, Elise, Weisser, Erin, Bautista, Rafael O., Henn, Madeline A., Schane, Claire P., Nelczyk, Adam T., Ma, Liqian, Das Gupta, Anasuya, Bendre, Shruti V., Nguyen, Tiffany, Tiwari, Srishti, Krawczynska, Natalia, He, Sisi, Tjoanda, Evelyn, Chen, Hong, Sverdlov, Maria, Gann, Peter H., Boidot, Romain, Vegran, Frederique, Fanning, Sean W., Apetoh, Lionel, Hergenrother, Paul J., Nelson, Erik R.
Published in Cancer letters (10.08.2024)
Published in Cancer letters (10.08.2024)
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