Taxanes convert regions of perturbed microtubule growth into rescue sites
Rai, Ankit, Liu, Tianyang, Glauser, Simon, Katrukha, Eugene A, Estévez-Gallego, Juan, Rodríguez-García, Ruddi, Fang, Wei-Shuo, Díaz, J Fernando, Steinmetz, Michel O, Altmann, Karl-Heinz, Kapitein, Lukas C, Moores, Carolyn A, Akhmanova, Anna
Published in Nature materials (01.03.2020)
Published in Nature materials (01.03.2020)
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Targeting the tubulin C-terminal tail by charged small molecules
Li, Shuo, Mori, Mattia, Yang, Mingyan, Elfazazi, Soumia, Hortigüela, Rafael, Chan, Peter, Feng, Xinyue, Risinger, April, Yang, Zhiyou, Oliva, María Ángela, Fernando Díaz, J, Fang, Wei-Shuo
Published in Organic & biomolecular chemistry (21.12.2022)
Published in Organic & biomolecular chemistry (21.12.2022)
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Structural insight into the stabilization of microtubules by taxanes
Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Published in eLife (06.03.2023)
Published in eLife (06.03.2023)
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Journal Article
Synthesis and Cytotoxicity of 7,9- O -Linked Macrocyclic C-Seco Taxoids
Zhao, Yu, Wang, Tian-En, Mills, Alberto, Gago, Federico, Fang, Wei-Shuo
Published in Molecules (Basel, Switzerland) (08.06.2019)
Published in Molecules (Basel, Switzerland) (08.06.2019)
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Journal Article
Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods
Wang, Shao-Rong, Xu, Tingting, Deng, Kai, Wong, Chi-Wai, Liu, Jinsong, Fang, Wei-Shuo
Published in Molecules (Basel, Switzerland) (26.04.2017)
Published in Molecules (Basel, Switzerland) (26.04.2017)
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Journal Article
Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer
Chen, Li-Qing, Huang, Wei, Gao, Zhong-Gao, Fang, Wei-Shuo, Jin, Ming-Ji
Published in International journal of nanomedicine (01.01.2016)
Published in International journal of nanomedicine (01.01.2016)
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A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis
Coderch, Claire, Tang, Yong, Klett, Javier, Zhang, Shu-En, Ma, Yun-Tao, Wang Shaorong, Matesanz, Ruth, Pera, Benet, Canales, Angeles, Jimenez-Barbero, Jesus, Morreale, Antonio, Fernando Diaz, J., Fang, Wei-Shuo, Gago, Federico
Published in Organic & biomolecular chemistry (14.05.2013)
Published in Organic & biomolecular chemistry (14.05.2013)
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Journal Article
On the Chemical Constituents of Dipsacus asper
Tian, Xiao-Yan, Wang, Ying-Hong, Liu, Hong-Yue, Yu, Shi-Shan, Fang, Wei-Shuo
Published in Chemical & Pharmaceutical Bulletin (01.12.2007)
Published in Chemical & Pharmaceutical Bulletin (01.12.2007)
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Journal Article
Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates
Sun, Hua, Yue, Partick Y K, Wang, Shao-Rong, Huo, Lihong, Zhao, Ying, Xie, Songbo, Kringelum, Jens V, Lund, Ole, Taboureau, Olivier, Zhou, Jun, Wong, Ricky N S, Fang, Wei-Shuo
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.12.2016)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.12.2016)
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Journal Article
BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta
Tian, Xiao-Yan, Zhao, Ying, Yu, Shi-Shan, Fang, Wei-Shuo
Published in Chemistry & biodiversity (01.04.2010)
Published in Chemistry & biodiversity (01.04.2010)
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Journal Article
Synthesis and biological activities of high affinity taxane-based fluorescent probes
Li, Xuan, Barasoain, Isabel, Matesanz, Ruth, Fernando Díaz, J., Fang, Wei-Shuo
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Overcoming Tumor Drug Resistance with High-Affinity Taxanes: A SAR Study of C2-Modified 7-Acyl-10-Deacetyl Cephalomannines
Yang, Chun-Gang, Barasoain, Isabel, Li, Xuan, Matesanz, Ruth, Liu, Ronghua, Sharom, Frances J., Yin, Da-Li, Díaz, J. Fernando, Fang, Wei-Shuo
Published in ChemMedChem (14.05.2007)
Published in ChemMedChem (14.05.2007)
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Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo
Wang, Shaorong, Huan, Yi, Niu, Shuaishuai, Cao, Hui, Yang, Mingyan, Zhou, Xinyue, Gao, Xuefeng, Wang, Xing, Shen, Zhufang, Fang, Wei-Shuo
Published in Bioorganic chemistry (01.12.2022)
Published in Bioorganic chemistry (01.12.2022)
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Journal Article
Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency
Ma, Yuntao, Josa-Prado, Fernando, Essif, Jacob Nathaniel, Liu, Shuqi, Li, Shuo, Lucena-Agell, Daniel, Chan, Peter YW, Goossens, Kenneth, Hortigüela, Rafael, Matesanz, Ruth, Wang, Yingjie, Gago, Federico, Wang, Hongbo, Risinger, April, Diaz, J. Fernando, Fang, Wei-Shuo
Published in European journal of medicinal chemistry (05.11.2023)
Published in European journal of medicinal chemistry (05.11.2023)
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Journal Article
A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility
Ma, Yun-Tao, Yang, Yanting, Cai, Pei, Sun, De-Yang, Sánchez-Murcia, Pedro A, Zhang, Xiao-Ying, Jia, Wen-Qiang, Lei, Lei, Guo, Mengqi, Gago, Federico, Wang, Hongbo, Fang, Wei-Shuo
Published in Journal of natural products (Washington, D.C.) (23.03.2018)
Published in Journal of natural products (Washington, D.C.) (23.03.2018)
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Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
Fang, Wei-Shuo, Sun, De-yang, Yang, Shuang, Cheng, Chen, Moschke, Katrin, Li, Tianqi, Sun, Shanshan, Lichtenthaler, Stefan F., Huang, Jian, Wang, Yinghong
Published in Bioorganic chemistry (01.11.2019)
Published in Bioorganic chemistry (01.11.2019)
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