Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human
Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat
Published in Molecular pharmaceutics (02.11.2020)
Published in Molecular pharmaceutics (02.11.2020)
Get full text
Journal Article
Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine
Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P, Fan, Peter W, Takahashi, Ryan H, Khojasteh, S Cyrus, Smith, Bill J, Murray, Bernard P, Thummel, Kenneth, Prasad, Bhagwat
Published in Drug metabolism and disposition (01.07.2020)
Published in Drug metabolism and disposition (01.07.2020)
Get full text
Journal Article
Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites
Yu, Zaikuan J., Roesner, Joseph M., Lutz, Ryan, Liang, Yuexia, Baker, James, Smith, Dustin M., Fan, Peter W.
Published in Drug metabolism and pharmacokinetics (01.10.2019)
Published in Drug metabolism and pharmacokinetics (01.10.2019)
Get full text
Journal Article
Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species
Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
Get full text
Journal Article
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat
Fan, Peter W, Chen, Jacob Z, Allan Jaochico, M, La, Hank, Liu, Ning, Mulder, Teresa, Cass, Robert T, Durk, Matthew, Messick, Kirsten, Valle, Nicole, Liu, Shannon, Lee, Wendy, Crawford, James J, Rudolf, Joachim, Murray, Lesley J, Cyrus Khojasteh, S, Wright, Matthew
Published in Drug metabolism letters (01.06.2016)
Published in Drug metabolism letters (01.06.2016)
Get more information
Journal Article
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
Brightbill, Hans D., Suto, Eric, Blaquiere, Nicole, Ramamoorthi, Nandhini, Sujatha-Bhaskar, Swathi, Gogol, Emily B., Castanedo, Georgette M., Jackson, Benjamin T., Kwon, Youngsu C., Haller, Susan, Lesch, Justin, Bents, Karin, Everett, Christine, Kohli, Pawan Bir, Linge, Sandra, Christian, Laura, Barrett, Kathy, Jaochico, Allan, Berezhkovskiy, Leonid M., Fan, Peter W., Modrusan, Zora, Veliz, Kelli, Townsend, Michael J., DeVoss, Jason, Johnson, Adam R., Godemann, Robert, Lee, Wyne P., Austin, Cary D., McKenzie, Brent S., Hackney, Jason A., Crawford, James J., Staben, Steven T., Alaoui Ismaili, Moulay H., Wu, Lawren C., Ghilardi, Nico
Published in Nature communications (12.01.2018)
Published in Nature communications (12.01.2018)
Get full text
Journal Article
Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
Fan, Peter W, Zhang, Donglu, Halladay, Jason S, Driscoll, James P, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
Get full text
Journal Article
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design
Crawford, James J., Feng, Jianwen, Brightbill, Hans D., Johnson, Adam R., Wright, Matthew, Kolesnikov, Aleksandr, Lee, Wendy, Castanedo, Georgette M., Do, Steven, Blaquiere, Nicole, Staben, Steven T., Chiang, Po-Chang, Fan, Peter W., Baumgardner, Matt, Wong, Susan, Godemann, Robert, Grabbe, Alice, Wiegel, Catharina, Sujatha-Bhaskar, Swathi, Hymowitz, Sarah G., Liau, Nicholas, Hsu, Peter L., McEwan, Paul A., Ismaili, Moulay Hicham Alaoui, Landry, Matthew L.
Published in Bioorganic & medicinal chemistry letters (01.06.2023)
Published in Bioorganic & medicinal chemistry letters (01.06.2023)
Get full text
Journal Article
Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection
Caniga, Michael, Yu, Hongshi, Lee, Hyun-Hee, Wang, Meiyao, Witter, David, Salmon, Michael, Fan, Peter W
Published in Journal of aerosol medicine and pulmonary drug delivery (01.10.2019)
Published in Journal of aerosol medicine and pulmonary drug delivery (01.10.2019)
Get full text
Journal Article
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors
Crawford, James J, Lee, Wendy, Aliagas, Ignacio, Mathieu, Simon, Hoeflich, Klaus P, Zhou, Wei, Wang, Weiru, Rouge, Lionel, Murray, Lesley, La, Hank, Liu, Ning, Fan, Peter W, Cheong, Jonathan, Heise, Christopher E, Ramaswamy, Sreemathy, Mintzer, Robert, Liu, Yanzhou, Chao, Qi, Rudolph, Joachim
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
Get full text
Journal Article
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology
Lu, Min, Zhang, Hongjun, Li, Derun, Childers, Matthew, Pu, Qinglin, Palte, Rachel L, Gathiaka, Symon, Lyons, Thomas W, Palani, Anandan, Fan, Peter W, Spacciapoli, Peter, Miller, J. Richard, Cho, Hyelim, Cheng, Mangeng, Chakravarthy, Kalyan, O’Neil, Jennifer, Eangoor, Padmanabhan, Beard, Adam, Kim, Hai-Young, Saurí, Josep, Gunaydin, Hakan, Sloman, David L, Siliphaivanh, Phieng, Cumming, Jared, Fischer, Christian
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
Get full text
Journal Article
Mechanism-Based Inactivation of Cytochrome P450 2B6 by a Novel Terminal Acetylene Inhibitor
FAN, Peter W, CHUNGANG GU, MARSH, Sandra A, STEVENS, Jeffrey C
Published in Drug metabolism and disposition (01.01.2003)
Published in Drug metabolism and disposition (01.01.2003)
Get full text
Journal Article
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP
Johnson, Michael G., Liu, Jim (Jiwen), Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C., Collins, Tassie L., Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L., Fan, Peter W., Wong, Simon G. W.
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
Get full text
Journal Article
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System
Wang, Xiaojing, Sun, Minghua, New, Connie, Nam, Spencer, Blackaby, Wesley P, Hodges, Alastair J, Nash, David, Matteucci, Mizio, Lyssikatos, Joseph P, Fan, Peter W, Tay, Suzanne, Chang, Jae H
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
Get full text
Journal Article