Acylguanidines as Small-Molecule β-Secretase Inhibitors
Cole, Derek C, Manas, Eric S, Stock, Joseph R, Condon, Jeffrey S, Jennings, Lee D, Aulabaugh, Ann, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jin, Guixan, Lin, Laura, Lovering, Frank E, Malamas, Michael S, Stahl, Mark L, Strand, James, Sukhdeo, Mohani N, Svenson, Kristine, Turner, M. James, Wagner, Erik, Wu, Junjun, Zhou, Ping, Bard, Jonathan
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Journal Article
Acylguanidine inhibitors of β-secretase : Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets
COLE, Derek C, STOCK, Joseph R, GUIXIAN JIN, LOHSE, Peter A, MALAMAS, Michael S, MANAS, Eric S, MOORE, William J, O'DONNELL, Mary-Margaret, OLLAND, Andrea M, ROBICHAUD, Albert J, SVENSON, Kristine, JUNJUN WU, CHOPRA, Rajiv, WAGNER, Eric, BARD, Jonathan, COWLING, Rebecca, ELLINGBOE, John W, FAN, Kristi Y, HARRISON, Boyd L, YUN HU, JACOBSEN, Steve, JENNINGS, Lee D
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
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Journal Article
Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors
Nowak, Pawel, Cole, Derek C., Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y., Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S., Manas, Eric S., Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J., Stock, Joseph R., Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Acylguanidine inhibitors of β-secretase : Optimization of the pyrrole ring substituents extending into the S'1 substrate binding pocket
JENNINGS, Lee D, COLE, Derek C, HARRISON, Boyd L, JACOBSEN, Steve, CHOPRA, Rajiv, LOHSE, Peter A, MOORE, William J, O'DONNELL, Mary-Margaret, YUN HU, ROBICHAUD, Albert J, TURNER, M. James, WAGNER, Erik, STOCK, Joseph R, BARD, Jonathan, SUKHDEO, Mohani N, ELLINGBOE, John W, COWLING, Rebecca, GUIXIAN JIN, MANAS, Eric S, FAN, Kristi Y, MALAMAS, Michael S
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the substrate binding pocket
Jennings, Lee D., Cole, Derek C., Stock, Joseph R., Sukhdeo, Mohani N., Ellingboe, John W., Cowling, Rebecca, Jin, Guixian, Manas, Eric S., Fan, Kristi Y., Malamas, Michael S., Harrison, Boyd L., Jacobsen, Steve, Chopra, Rajiv, Lohse, Peter A., Moore, William J., O’Donnell, Mary-Margaret, Hu, Yun, Robichaud, Albert J., Turner, M. James, Wagner, Erik, Bard, Jonathan
Published in Bioorganic & medicinal chemistry (01.01.2008)
Published in Bioorganic & medicinal chemistry (01.01.2008)
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Journal Article
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 and S 3 substrate binding pockets
Cole, Derek C., Stock, Joseph R., Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W., Fan, Kristi Y., Harrison, Boyd L., Hu, Yun, Jacobsen, Steve, Jennings, Lee D., Jin, Guixian, Lohse, Peter A., Malamas, Michael S., Manas, Eric S., Moore, William J., O’Donnell, Mary-Margaret, Olland, Andrea M., Robichaud, Albert J., Svenson, Kristine, Wu, JunJun, Wagner, Eric, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
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Journal Article
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 ′ substrate binding pocket
Jennings, Lee D., Cole, Derek C., Stock, Joseph R., Sukhdeo, Mohani N., Ellingboe, John W., Cowling, Rebecca, Jin, Guixian, Manas, Eric S., Fan, Kristi Y., Malamas, Michael S., Harrison, Boyd L., Jacobsen, Steve, Chopra, Rajiv, Lohse, Peter A., Moore, William J., O’Donnell, Mary-Margaret, Hu, Yun, Robichaud, Albert J., Turner, M. James, Wagner, Erik, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent b-secretase (BACE1) inhibitors
Nowak, Pawel, Cole, Derek C, Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y, Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S, Manas, Eric S, Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J, Stock, Joseph R, Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Novel triazines as potent and selective phosphodiesterase 10A inhibitors
Malamas, Michael S., Stange, Hans, Schindler, Rudolf, Lankau, Hans-Joachim, Grunwald, Christian, Langen, Barbara, Egerland, Ute, Hage, Thorsten, Ni, Yike, Erdei, James, Fan, Kristi Yi, Parris, Kevin, Marquis, Karen L., Grauer, Steve, Brennan, Julie, Navarra, Rachel, Graf, Radka, Harrison, Boyd L., Robichaud, Albert, Kronbach, Thomas, Pangalos, Menelas N., Brandon, Nicholas J., Hoefgen, Norbert
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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Journal Article
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2′ region
Malamas, Michael S., Erdei, Jim, Gunawan, Iwan, Barnes, Keith, Hui, Yu, Johnson, Matthew, Robichaud, Albert, Zhou, Ping, Yan, Yinfa, Solvibile, William, Turner, Jim, Fan, Kristi Yi, Chopra, Rajiv, Bard, Jonathan, Pangalos, Menelas N.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Acylguanidine inhibitors of beta -secretase: Optimization of the pyrrole ring substituents extending into the S sub(1) and S sub(3) substrate binding pockets
Cole, Derek C, Stock, Joseph R, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jennings, Lee D, Jin, Guixian, Lohse, Peter A, Malamas, Michael S, Manas, Eric S, Moore, William J, O'Donnell, Mary-Margaret, Olland, Andrea M, Robichaud, Albert J, Svenson, Kristine, Wu, JunJun, Wagner, Eric, Bard, Jonathan
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors
Hu, Baihua, Fan, Kristi Yi, Bridges, Kristie, Chopra, Rajiv, Lovering, Frank, Cole, Derek, Zhou, Ping, Ellingboe, John, Jin, Guixiang, Cowling, Rebecca, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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