Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Chen, Jun, Joshi, Shailen K., DiDomenico, Stanley, Perner, Richard J., Mikusa, Joe P., Gauvin, Donna M., Segreti, Jason A., Han, Ping, Zhang, Xu-Feng, Niforatos, Wende, Bianchi, Bruce R., Baker, Scott J., Zhong, Chengmin, Simler, Gricelda H., McDonald, Heath A., Schmidt, Robert G., McGaraughty, Steve P., Chu, Katharine L., Faltynek, Connie R., Kort, Michael E., Reilly, Regina M., Kym, Philip R.
Published in Pain (Amsterdam) (01.05.2011)
Published in Pain (Amsterdam) (01.05.2011)
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Journal Article
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Jarvis, Michael F, Honore, Prisca, Shieh, Char-Chang, Chapman, Mark, Joshi, Shailen, Zhang, Xu-Feng, Kort, Michael, Carroll, William, Marron, Brian, Atkinson, Robert, Thomas, James, Liu, Dong, Krambis, Michael, Liu, Yi, McGaraughty, Steve, Chu, Katharine, Roeloffs, Rosemarie, Zhong, Chengmin, Mikusa, Joseph P, Hernandez, Gricelda, Gauvin, Donna, Wade, Carrie, Zhu, Chang, Pai, Madhavi, Scanio, Marc, Shi, Lei, Drizin, Irene, Gregg, Robert, Matulenko, Mark, Hakeem, Ahmed, Gross, Michael, Johnson, Matthew, Marsh, Kennan, Wagoner, P. Kay, Sullivan, James P, Faltynek, Connie R, Krafte, Douglas S
Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)
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A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Honore, Prisca, Donnelly-Roberts, Diana, Namovic, Marian T, Hsieh, Gin, Zhu, Chang Z, Mikusa, Joe P, Hernandez, Gricelda, Zhong, Chengmin, Gauvin, Donna M, Chandran, Prasant, Harris, Richard, Medrano, Arturo Perez, Carroll, William, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Journal Article
Transient receptor potential A1 mediates an osmotically activated ion channel
Zhang, Xu-Feng, Chen, Jun, Faltynek, Connie R., Moreland, Robert B., Neelands, Torben R.
Published in The European journal of neuroscience (01.02.2008)
Published in The European journal of neuroscience (01.02.2008)
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Journal Article
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.
Published in Pain (Amsterdam) (01.03.2009)
Published in Pain (Amsterdam) (01.03.2009)
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Journal Article
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats
Honore, Prisca, Wismer, Carol T, Mikusa, Joe, Zhu, Chang Z, Zhong, Chengmin, Gauvin, Donna M, Gomtsyan, Arthur, El Kouhen, Rachid, Lee, Chih-Hung, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Journal Article
Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels
Chen, Jun, Kim, Donghee, Bianchi, Bruce R, Cavanaugh, Eric J, Faltynek, Connie R, Kym, Philip R, Reilly, Regina M
Published in Molecular pain (21.01.2009)
Published in Molecular pain (21.01.2009)
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Journal Article
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
Chen, Jun, Zhang, Xu-Feng, Kort, Michael E, Huth, Jeffrey R, Sun, Chaohong, Miesbauer, Laura J, Cassar, Steven C, Neelands, Torben, Scott, Victoria E, Moreland, Robert B, Reilly, Regina M, Hajduk, Philip J, Kym, Philip R, Hutchins, Charles W, Faltynek, Connie R
Published in The Journal of neuroscience (07.05.2008)
Published in The Journal of neuroscience (07.05.2008)
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Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats
HONORE, Prisca, KAGE, Karen, MIKUSA, Joseph, WATT, Andrew T, JOHNSTON, Joseph F, WYATT, Jacqueline R, FALTYNEK, Connie R, JARVIS, Michael F, LYNCH, Kevin
Published in Pain (Amsterdam) (01.09.2002)
Published in Pain (Amsterdam) (01.09.2002)
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Journal Article
Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells
Donnelly-Roberts, Diana L, Namovic, Marian T, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
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Journal Article
A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
McGaraughty, Steve, Chu, Katharine L, Scanio, Marc J C, Kort, Michael E, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Journal Article
Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia
ZHANG, Xu-Feng, PING HAN, FALTYNEK, Connie R, JARVIS, Michael F, SHIEH, Char-Chang
Published in Brain research (02.08.2005)
Published in Brain research (02.08.2005)
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Journal Article
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
Niforatos, Wende, Zhang, Xu-Feng, Lake, Marc R, Walter, Karl A, Neelands, Torben, Holzman, Thomas F, Scott, Victoria E, Faltynek, Connie R, Moreland, Robert B, Chen, Jun
Published in Molecular pharmacology (01.05.2007)
Published in Molecular pharmacology (01.05.2007)
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Journal Article
A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
El Kouhen, Rachid, Surowy, Carol S, Bianchi, Bruce R, Neelands, Torben R, McDonald, Heath A, Niforatos, Wende, Gomtsyan, Arthur, Lee, Chih-Hung, Honore, Prisca, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Journal Article
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
Vos, Melissa H., Neelands, Torben R., McDonald, Heath A., Choi, Won, Kroeger, Paul E., Puttfarcken, Pamela S., Faltynek, Connie R., Moreland, Robert B., Han, Ping
Published in Journal of neurochemistry (01.11.2006)
Published in Journal of neurochemistry (01.11.2006)
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Journal Article
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
Surowy, Carol S, Neelands, Torben R, Bianchi, Bruce R, McGaraughty, Steve, El Kouhen, Rachid, Han, Ping, Chu, Katharine L, McDonald, Heath A, Vos, Melissa, Niforatos, Wende, Bayburt, Erol K, Gomtsyan, Arthur, Lee, Chih-Hung, Honore, Prisca, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Journal Article
Central Pituitary Adenylate Cyclase 1 Receptors Modulate Nociceptive Behaviors in Both Inflammatory and Neuropathic Pain States
Davis-Taber, Rachel, Baker, Scott, Lehto, Sonya G, Zhong, Chengmin, Surowy, Carol S, Faltynek, Connie R, Scott, Victoria E, Honore, Prisca
Published in The journal of pain (01.05.2008)
Published in The journal of pain (01.05.2008)
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