The Structural Biology of Bcl-xL
Lee, Erinna F., Fairlie, W. Douglas
Published in International journal of molecular sciences (07.05.2019)
Published in International journal of molecular sciences (07.05.2019)
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Journal Article
BECLIN1: Protein Structure, Function and Regulation
Tran, Sharon, Fairlie, W. Douglas, Lee, Erinna F.
Published in Cells (Basel, Switzerland) (17.06.2021)
Published in Cells (Basel, Switzerland) (17.06.2021)
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Journal Article
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth M., Adams, Jerry M., Colman, Peter M.
Published in Cell (31.01.2013)
Published in Cell (31.01.2013)
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Journal Article
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Glaser, Stefan P, Lee, Erinna F, Trounson, Evelyn, Bouillet, Philippe, Wei, Andrew, Fairlie, W Douglas, Izon, David J, Zuber, Johannes, Rappaport, Amy R, Herold, Marco J, Alexander, Warren S, Lowe, Scott W, Robb, Lorraine, Strasser, Andreas
Published in Genes & development (15.01.2012)
Published in Genes & development (15.01.2012)
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Journal Article
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J., Fairlie, W. Douglas
Published in Cell death & disease (24.04.2019)
Published in Cell death & disease (24.04.2019)
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Journal Article
Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo
Ji, Yanhao, Harris, Michael A, Newton, Lucas M, Harris, Tiffany J, Fairlie, W Douglas, Lee, Erinna F, Hawkins, Christine J
Published in BMC cancer (04.11.2024)
Published in BMC cancer (04.11.2024)
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Journal Article
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Kelly, Gemma L, Grabow, Stephanie, Glaser, Stefan P, Fitzsimmons, Leah, Aubrey, Brandon J, Okamoto, Toru, Valente, Liz J, Robati, Mikara, Tai, Lin, Fairlie, W Douglas, Lee, Erinna F, Lindstrom, Mikael S, Wiman, Klas G, Huang, David C S, Bouillet, Philippe, Rowe, Martin, Rickinson, Alan B, Herold, Marco J, Strasser, Andreas
Published in Genes & development (01.01.2014)
Published in Genes & development (01.01.2014)
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Journal Article
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
O’ Reilly, Lorraine A., Tai, Lin, Lee, Lily, Kruse, Elizabeth A., Grabow, Stephanie, Fairlie, W. Douglas, Haynes, Nicole M., Tarlinton, David M., Zhang, Jian-Guo, Belz, Gabrielle T., Smyth, Mark J., Bouillet, Philippe, Robb, Lorraine, Strasser, Andreas
Published in Nature (London) (01.10.2009)
Published in Nature (London) (01.10.2009)
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Journal Article
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David
Published in eLife (02.11.2016)
Published in eLife (02.11.2016)
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Journal Article
Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
Dmello, Rhynelle S., Palmieri, Michelle, Thilakasiri, Pathum S., Doughty, Larissa, Nero, Tracy L., Poh, Ashleigh R., To, Sarah Q., Lee, Erinna F., Douglas Fairlie, W., Mielke, Lisa, Parker, Michael W., Poon, Ivan K. H., Batlle, Eduard, Ernst, Matthias, Chand, Ashwini L.
Published in Cell death & disease (10.04.2024)
Published in Cell death & disease (10.04.2024)
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Journal Article
Structural insights into the degradation of Mcl-1 induced by BH3 domains
Czabotar, Peter E, Lee, Erinna F, van Delft, Mark F, Day, Catherine L, Smith, Brian J, Huang, David C.S, Fairlie, W. Douglas, Hinds, Mark G, Colman, Peter M
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
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Journal Article
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
Fletcher, Jamie I, Meusburger, Sarina, Hawkins, Christine J, Riglar, David T, Lee, Erinna F, Fairlie, W. Douglas, Huang, David C.S, Adams, Jerry M
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2008)
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Journal Article
High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL
Lee, Erinna F, Sadowsky, Jack D, Smith, Brian J, Czabotar, Peter E, Peterson-Kaufman, Kimberly J, Colman, Peter M, Gellman, Samuel H, Fairlie, W. Douglas
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Journal Article
Physiological restraint of Bak by Bcl-xL is essential for cell survival
Lee, Erinna F, Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M, Debrincat, Marlyse A, Gray, Daniel H, Witkowski, Matthew T, Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M, Czabotar, Peter E, Colman, Peter M, Smith, Brian J, Kile, Benjamin T, Fairlie, W Douglas
Published in Genes & development (15.05.2016)
Published in Genes & development (15.05.2016)
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Journal Article
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking
Tran, Sharon, Juliani, Juliani, Harris, Tiffany J., Evangelista, Marco, Ratcliffe, Julian, Ellis, Sarah L., Baloyan, David, Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura J., Ghilas, Sonia, Yakou, Marina H., Inguanti, Chantelle, Johnson, Chad, Buchert, Michael, Lee, James C., De Cruz, Peter, Duszyc, Kinga, Gleeson, Paul A., Kile, Benjamin T., Mielke, Lisa A., Yap, Alpha S., Mariadason, John M., Fairlie, W. Douglas, Lee, Erinna F.
Published in Communications biology (20.02.2024)
Published in Communications biology (20.02.2024)
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Journal Article
Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells
Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Grabow, Stephanie, Ottina, Eleonora, Herold, Marco J., Pellegrini, Marc, Huang, David C. S., Tarlinton, David M., Strasser, Andreas, Lew, Andrew M., Zhan, Yifan
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2015)
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Journal Article
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
Lee, Erinna F., Czabotar, Peter E., Yang, Hong, Sleebs, Brad E., Lessene, Guillaume, Colman, Peter M., Smith, Brian J., Fairlie, W.Douglas
Published in The Journal of biological chemistry (30.10.2009)
Published in The Journal of biological chemistry (30.10.2009)
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Journal Article
Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl‑XL
Sleebs, Brad E, Kersten, Wilhemus J. A, Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M, Parisot, John P, Yang, Hong, Czabotar, Peter E, Fairlie, W. Douglas, Lee, Erinna F, Adams, Jerry M, Chen, Lin, van Delft, Mark F, Lowes, Kym N, Wei, Andrew, Huang, David C.S, Colman, Peter M, Street, Ian P, Baell, Jonathan B, Watson, Keith, Lessene, Guillaume
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Journal Article
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes
Lee, Erinna F, Clarke, Oliver B, Evangelista, Marco, Feng, Zhiping, Speed, Terence P, Tchoubrieva, Elissaveta B, Strasser, Andreas, Kalinna, Bernd H, Colman, Peter M, Fairlie, W. Douglas
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
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Journal Article
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy
White, Christine A, Zhang, Jian-Guo, Salamonsen, Lois A, Baca, Manuel, Fairlie, W. Douglas, Metcalf, Donald, Nicola, Nicos A, Robb, Lorraine, Dimitriadis, Evdokia
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
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