Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J, Gerrits, Danny, Geven, Edwin J W, Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J Mark, Garg, Pradeep K, Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity
Sam, Johannes, Colombetti, Sara, Fauti, Tanja, Roller, Andreas, Biehl, Marlene, Fahrni, Linda, Nicolini, Valeria, Perro, Mario, Nayak, Tapan, Bommer, Esther, Schoenle, Anne, Karagianni, Maria, Le Clech, Marine, Steinhoff, Nathalie, Klein, Christian, Umaña, Pablo, Bacac, Marina
Published in Frontiers in oncology (30.11.2020)
Published in Frontiers in oncology (30.11.2020)
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Journal Article
Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure
Spreafico, Anna, Couselo, Eva Muñoz, Irmisch, Anja, Bessa, Juliana, Au-Yeung, George, Bechter, Oliver, Svane, Inge Marie, Sanmamed, Miguel F, Gambardella, Valentina, McKean, Meredith, Callahan, Margaret, Dummer, Reinhard, Klein, Christian, Umaña, Pablo, Justies, Nicole, Heil, Florian, Fahrni, Linda, Opolka-Hoffmann, Eugenia, Waldhauer, Inja, Bleul, Conrad, Staack, Roland F, Karanikas, Vaios, Fowler, Stephen
Published in Frontiers in oncology (21.03.2024)
Published in Frontiers in oncology (21.03.2024)
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Journal Article
Corrigendum: Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity
Sam, Johannes, Colombetti, Sara, Fauti, Tanja, Roller, Andreas, Biehl, Marlene, Fahrni, Linda, Nicolini, Valeria, Perro, Mario, Nayak, Tapan, Bommer, Esther, Schoenle, Anne, Karagianni, Maria, Le Clech, Marine, Steinhoff, Nathalie, Klein, Christian, Umaña, Pablo, Bacac, Marina
Published in Frontiers in oncology (03.02.2021)
Published in Frontiers in oncology (03.02.2021)
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Journal Article
Correction: Preclinical In Vivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 TâCell Bispecific in Combination with AntiâPDâL1
Sánchez, Javier, Nicolini, Valeria, Fahrni, Linda, Waldhauer, Inja, Walz, AntjeâChristine, Jamois, Candice, Fowler, Stephen
Published in The AAPS journal (01.05.2023)
Published in The AAPS journal (01.05.2023)
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Journal Article
A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
Herter, Sylvia, Morra, Laura, Schlenker, Ramona, Sulcova, Jitka, Fahrni, Linda, Waldhauer, Inja, Lehmann, Steffi, Reisländer, Timo, Agarkova, Irina, Kelm, Jens M., Klein, Christian, Umana, Pablo, Bacac, Marina
Published in Cancer Immunology, Immunotherapy (01.01.2017)
Published in Cancer Immunology, Immunotherapy (01.01.2017)
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Journal Article
In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing
Lehmann, Steffi, Perera, Ramanil, Grimm, Hans-Peter, Sam, Johannes, Colombetti, Sara, Fauti, Tanja, Fahrni, Linda, Schaller, Teilo, Freimoser-Grundschober, Anne, Zielonka, Jörg, Stoma, Szymon, Rudin, Markus, Klein, Christian, Umana, Pablo, Gerdes, Christian, Bacac, Marina
Published in Clinical cancer research (01.09.2016)
Published in Clinical cancer research (01.09.2016)
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Journal Article
Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1
Sánchez, Javier, Nicolini, Valeria, Fahrni, Linda, Waldhauer, Inja, Walz, Antje-Christine, Jamois, Candice, Fowler, Stephen, Simon, Silke, Klein, Christian, Umaña, Pablo, Friberg, Lena E., Frances, Nicolas
Published in The AAPS journal (07.10.2022)
Published in The AAPS journal (07.10.2022)
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Journal Article
Correction: Preclinical In Vivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T‑Cell Bispecific in Combination with Anti‑PD‑L1
Sánchez, Javier, Nicolini, Valeria, Fahrni, Linda, Waldhauer, Inja, Walz, Antje‑Christine, Jamois, Candice, Fowler, Stephen, Simon, Silke, Klein, Christian, Umaña, Pablo, Friberg, Lena E., Frances, Nicolas
Published in The AAPS journal (01.04.2023)
Published in The AAPS journal (01.04.2023)
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Journal Article
A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma
Iurlaro, Raffaella, Waldhauer, Inja, Planas-Rigol, Ester, Bonfill-Teixidor, Ester, Arias, Alexandra, Nicolini, Valeria, Freimoser-Grundschober, Anne, Cuartas, Isabel, Martínez-Moreno, Alba, Martínez-Ricarte, Francisco, Cordero, Esteban, Cicuendez, Marta, Casalino, Simona, Guardia-Reyes, Xavier, Fahrni, Linda, Pöschinger, Thomas, Steinhart, Virginie, Richard, Marine, Briner, Stefanie, Mueller, Joerg, Osl, Franz, Sam, Johannes, Colombetti, Sara, Bacac, Marina, Klein, Christian, Pineda, Estela, Reyes-Figueroa, Luis, Di Somma, Alberto, González, Josep, Nuciforo, Paolo, Carles, Joan, Vieito, Maria, Tabernero, Josep, Umaña, Pablo, Seoane, Joan
Published in Molecular cancer therapeutics (07.10.2022)
Published in Molecular cancer therapeutics (07.10.2022)
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Journal Article
Abstract LB-389: Combination of TYRP1-TCB, a novel T cell bispecific antibody for the treatment of melanoma, with immunomodulatory agents
Nicolini, Valeria G., Waldhauer, Inja, Freimoser-Grundschober, Anne, Richard, Marine, Fahrni, Linda, Bommer, Esther, Claus, Christina, Sam, Johannes, Colombetti, Sara, Sutmuller, Roger, Levesque, Mitchell P., Irmisch, Anja, Bleul, Conrad, Campbell, Neil, Bacac, Marina, Moessner, Ekkehard, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 1494: Combination of CEA TCB, a novel T-cell bispecific antibody for the treatment of solid tumors, with PD-L1 checkpoint blockade
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Fahrni, Linda, Nicolini, Valeria, Gerdes, Christian, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 1594: Enhancement of the anti-tumor activity of CEA TCB via combination with checkpoint blockade by PD-L1 and interleukin-2 variant immunocytokine
Bacac, Marina, Colombetti, Sara, Fahrni, Linda, Fauti, Tanja, Nicolini, Valeria, Sam, Johannes, Papastogiannidis, Petros, Clech, Marine Le, Miot, Xavier, Waldhauer, Inja, Rommel, Karolin, Gerdes, Christian, Klein, Christian, Umaña, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs
Klein, Christian, Neumann, Christiane, Fauti, Tanja, Weinzierl, Tina, Freimoser-Grundschober, Anne, Waldhauer, Inja, Fahrni, Linda, Herter, Sylvia, Puijenbroek, Erwin van, Colombetti, Sara, Sam, Johannes, Lang, Sabine, Dudal, Sherri, Schäfer, Wolfgang, Regula, Jörg T., Moser, Samuel, Ast, Oliver, Hosse, Ralf, Mössner, Ekkehard, Brünker, Peter, Bacac, Marina, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
IMMUNOCONJUGATES
FAHRNI, Linda, HOSSE, Ralf, KLEIN, Christian, UMAÑA, Pablo, WALDHAUER, Inja
Year of Publication 14.07.2022
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Year of Publication 14.07.2022
Patent
PROTEASE-ACTIVATED POLYPEPTIDES
FAHRNI, Linda, FREIMOSER-GRUNDSCHOBER, Anne, GEIGER, Martina, HOSSE, Ralf, SAUER, Evelyn, CALABRO, Samuele, KLEIN, Christian, UMAÑA, Pablo, BRUENKER, Peter, MOESSNER, Ekkehard, WALDHAUER, Inja
Year of Publication 14.11.2024
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Year of Publication 14.11.2024
Patent
PROTEASE-ACTIVATED POLYPEPTIDES
FAHRNI, Linda, FREIMOSER-GRUNDSCHOBER, Anne, CODARRI DEAK, Laura, HOSSE, Ralf, KLEIN, Christian, UMAÑA, Pablo, MOESSNER, Ekkehard, NICOLINI, Valeria, DURINI, Greta, WALDHAUER, Inja
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent
PROTEASE-ACTIVATED POLYPEPTIDES
FAHRNI, Linda, FREIMOSER-GRUNDSCHOBER, Anne, GEIGER, Martina, HOSSE, Ralf, SAUER, Evelyn, CALABRO, Samuele, KLEIN, Christian, UMAÑA, Pablo, BRUENKER, Peter, MOESSNER, Ekkehard, WALDHAUER, Inja
Year of Publication 07.02.2024
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Year of Publication 07.02.2024
Patent
PROTEASE-ACTIVATED POLYPEPTIDES
FAHRNI, Linda, FREIMOSER-GRUNDSCHOBER, Anne, GEIGER, Martina, HOSSE, Ralf, SAUER, Evelyn, CALABRO, Samuele, KLEIN, Christian, UMAÑA, Pablo, BRUENKER, Peter, MOESSNER, Ekkehard, WALDHAUER, Inja
Year of Publication 06.10.2022
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Year of Publication 06.10.2022
Patent
Protease-activated polypeptides
NICOLINI, VALERIA, WALDHAUER, INJA, HOSSE, RALF, FAHRNI, LINDA, FREIMOSER-GRUNDSCHOBER, ANNE, KLEIN, CHRISTIAN, DURINI, GRETA, MOESSNER, EKKEHARD, UMANA, PABLO, CODARRI DEAK, LAURA
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
Patent