2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism
Fader, Kelly A, Nault, Rance, Zhang, Chen, Kumagai, Kazuyoshi, Harkema, Jack R, Zacharewski, Timothy R
Published in Scientific reports (19.07.2017)
Published in Scientific reports (19.07.2017)
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Journal Article
Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo‑p‑dioxin
Nault, Rance, Fader, Kelly A, Lydic, Todd A, Zacharewski, Timothy R
Published in Chemical research in toxicology (17.04.2017)
Published in Chemical research in toxicology (17.04.2017)
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Journal Article
Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis
Najt, Charles P, Senthivinayagam, Subramanian, Aljazi, Mohammad B, Fader, Kelly A, Olenic, Sandra D, Brock, Julienne R L, Lydic, Todd A, Jones, A Daniel, Atshaves, Barbara P
Published in American journal of physiology: Gastrointestinal and liver physiology (01.05.2016)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.05.2016)
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Journal Article
Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
Cholico, Giovan N, Orlowska, Karina, Fling, Russell R, Sink, Warren J, Zacharewski, Nicholas A, Fader, Kelly A, Nault, Rance, Zacharewski, Tim
Published in Scientific reports (13.03.2023)
Published in Scientific reports (13.03.2023)
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Journal Article
Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation
Cholico, Giovan N, Fling, Russell R, Zacharewski, Nicholas A, Fader, Kelly A, Nault, Rance, Zacharewski, Timothy R
Published in Scientific reports (03.08.2021)
Published in Scientific reports (03.08.2021)
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Journal Article
Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis
Nault, Rance, Fader, Kelly A, Ammendolia, Dustin A, Dornbos, Peter, Potter, Dave, Sharratt, Bonnie, Kumagai, Kazuyoshi, Harkema, Jack R, Lunt, Sophia Y, Matthews, Jason, Zacharewski, Tim
Published in Toxicological sciences (01.12.2016)
Published in Toxicological sciences (01.12.2016)
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Journal Article
2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice
Fader, Kelly A, Nault, Rance, Ammendolia, Dustin A, Harkema, Jack R, Williams, Kurt J, Crawford, Robert B, Kaminski, Norbert E, Potter, Dave, Sharratt, Bonnie, Zacharewski, Timothy R
Published in Toxicological sciences (01.12.2015)
Published in Toxicological sciences (01.12.2015)
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Journal Article
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
Fader, Kelly A., Pardo, Ingrid D., Kovi, Ramesh C., Somps, Christopher J., Wang, Helen Hong, Vaidya, Vishal S., Ramaiah, Shashi K., Sirivelu, Madhu P.
Published in Molecular therapy. Methods & clinical development (09.06.2022)
Published in Molecular therapy. Methods & clinical development (09.06.2022)
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Journal Article
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice
Fling, Russell R, Doskey, Claire M, Fader, Kelly A, Nault, Rance, Zacharewski, Tim R
Published in Scientific reports (09.09.2020)
Published in Scientific reports (09.09.2020)
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Journal Article
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats
Doskey, Claire M., Fader, Kelly A., Nault, Rance, Lydic, Todd, Matthews, Jason, Potter, Dave, Sharratt, Bonnie, Williams, Kurt, Zacharewski, Tim
Published in Toxicology and applied pharmacology (01.07.2020)
Published in Toxicology and applied pharmacology (01.07.2020)
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Journal Article
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity
Fader, Kelly A., Nault, Rance, Kirby, Mathew P., Markous, Gena, Matthews, Jason, Zacharewski, Timothy R.
Published in Toxicology and applied pharmacology (15.04.2017)
Published in Toxicology and applied pharmacology (15.04.2017)
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Journal Article
Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA
Fader, Kelly A., Gosink, Mark M., Xia, Shuhua, Lanz, Thomas A., Halsey, Charles, Vaidya, Vishal S., Radi, Zaher A.
Published in Toxicology and applied pharmacology (15.08.2023)
Published in Toxicology and applied pharmacology (15.08.2023)
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Journal Article
Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo- p -dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction
Nault, Rance, Doskey, Claire M, Fader, Kelly A, Rockwell, Cheryl E, Zacharewski, Tim
Published in Molecular pharmacology (01.08.2018)
Published in Molecular pharmacology (01.08.2018)
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Journal Article
Qualified kidney injury biomarkers demonstrate value during early clinical drug development
Ravindra, Kodihalli C, Fader, Kelly A, Potter, David, Radi, Zaher A, Friedman, Gary S, Brenneman, Karrie A, Amin, Neeta B, Weiss, Roberta, Danto, Spencer I, Page, Karen, Ramaiah, Shashi K, Vaidya, Vishal S
Published in Toxicological sciences (12.07.2024)
Published in Toxicological sciences (12.07.2024)
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