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Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A
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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
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Published in Cancer cell (14.01.2013)
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Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
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Published in Cancer cell (12.01.2015)
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Patient-derived models of acquired resistance can identify effective drug combinations for cancer
Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.
Published in Science (American Association for the Advancement of Science) (19.12.2014)
Published in Science (American Association for the Advancement of Science) (19.12.2014)
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MYCN -Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis
Floros, Konstantinos V, Cai, JinYang, Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K, Shende, Mayuri, Coon, Colin M, Powell, Krista M, Belvin, Benjamin R, Hu, Bin, Puchalapalli, Madhavi, Ramamoorthy, Sivapriya, Swift, Kimberly, Lewis, Janina P, Dozmorov, Mikhail G, Glod, John, Koblinski, Jennifer E, Boikos, Sosipatros A, Faber, Anthony C
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer
Kitai, Hidenori, Ebi, Hiromichi, Tomida, Shuta, Floros, Konstantinos V, Kotani, Hiroshi, Adachi, Yuta, Oizumi, Satoshi, Nishimura, Masaharu, Faber, Anthony C, Yano, Seiji
Published in Cancer discovery (01.07.2016)
Published in Cancer discovery (01.07.2016)
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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1
Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Pelle, Patricia Della, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
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Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
Guix, Marta, Faber, Anthony C, Wang, Shizhen Emily, Olivares, Maria Graciela, Song, Youngchul, Qu, Sherman, Rinehart, Cammie, Seidel, Brenda, Yee, Douglas, Arteaga, Carlos L, Engelman, Jeffrey A
Published in The Journal of clinical investigation (01.07.2008)
Published in The Journal of clinical investigation (01.07.2008)
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Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer
Shee, Kevin, Yang, Wei, Hinds, John W, Hampsch, Riley A, Varn, Frederick S, Traphagen, Nicole A, Patel, Kishan, Cheng, Chao, Jenkins, Nicole P, Kettenbach, Arminja N, Demidenko, Eugene, Owens, Philip, Faber, Anthony C, Golub, Todd R, Straussman, Ravid, Miller, Todd W
Published in The Journal of experimental medicine (05.03.2018)
Published in The Journal of experimental medicine (05.03.2018)
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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
Faber, Anthony C, Li, Danan, Song, YoungChul, Liang, Mei-Chih, Yeap, Beow Y, Bronson, Roderick T, Lifshits, Eugene, Chen, Zhao, Maira, Sauveur-Michel, García-Echeverría, Carlos, Wong, Kwok-Kin, Engelman, Jeffrey A
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
Lochmann, Timothy L, Powell, Krista M, Ham, Jungoh, Floros, Konstantinos V, Heisey, Daniel A R, Kurupi, Richard I J, Calbert, Marissa L, Ghotra, Maninderjit S, Greninger, Patricia, Dozmorov, Mikhail, Gowda, Madhu, Souers, Andrew J, Reynolds, C Patrick, Benes, Cyril H, Faber, Anthony C
Published in Science translational medicine (16.05.2018)
Published in Science translational medicine (16.05.2018)
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Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Song, Kyung-A, Niederst, Matthew J, Lochmann, Timothy L, Hata, Aaron N, Kitai, Hidenori, Ham, Jungoh, Floros, Konstantinos V, Hicks, Mark A, Hu, Haichuan, Mulvey, Hillary E, Drier, Yotam, Heisey, Daniel A R, Hughes, Mark T, Patel, Neha U, Lockerman, Elizabeth L, Garcia, Angel, Gillepsie, Shawn, Archibald, Hannah L, Gomez-Caraballo, Maria, Nulton, Tara J, Windle, Brad E, Piotrowska, Zofia, Sahingur, Sinem E, Taylor, Shirley M, Dozmorov, Mikhail, Sequist, Lecia V, Bernstein, Bradley, Ebi, Hiromichi, Engelman, Jeffrey A, Faber, Anthony C
Published in Clinical cancer research (01.01.2018)
Published in Clinical cancer research (01.01.2018)
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Increased synthesis of MCL-1 protein underlies initial survival of EGFR mutant lung cancer to EGFR inhibitors and provides a novel drug target
Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros A, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C
Published in Clinical cancer research (15.11.2018)
Published in Clinical cancer research (15.11.2018)
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Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment
Neely, Victoria, Manchikalapudi, Alekhya, Nguyen, Khanh, Dalton, Krista, Hu, Bin, Koblinski, Jennifer E, Faber, Anthony C, Deb, Sumitra, Harada, Hisashi
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
Faber, Anthony C., Farago, Anna F., Costa, Carlotta, Dastur, Anahita, Gomez-Caraballo, Maria, Robbins, Rebecca, Wagner, Bethany L., Rideout, William M., Jakubik, Charles T., Ham, Jungoh, Edelman, Elena J., Ebi, Hiromichi, Yeo, Alan T., Hata, Aaron N., Song, Youngchul, Patel, Neha U., March, Ryan J., Tam, Ah Ting, Milano, Randy J., Boisvert, Jessica L., Hicks, Mark A., Elmiligy, Sarah, Malstrom, Scott E., Rivera, Miguel N., Harada, Hisashi, Windle, Brad E., Ramaswamy, Sridhar, Benes, Cyril H., Jacks, Tyler, Engelman, Jeffrey A.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
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BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors
Faber, Anthony C, Corcoran, Ryan B, Ebi, Hiromichi, Sequist, Lecia V, Waltman, Belinda A, Chung, Euiheon, Incio, Joao, Digumarthy, Subba R, Pollack, Sarah F, Song, Youngchul, Muzikansky, Alona, Lifshits, Eugene, Roberge, Sylvie, Coffman, Erik J, Benes, Cyril H, Gómez, Henry L, Baselga, José, Arteaga, Carlos L, Rivera, Miguel N, Dias-Santagata, Dora, Jain, Rakesh K, Engelman, Jeffrey A
Published in Cancer discovery (01.09.2011)
Published in Cancer discovery (01.09.2011)
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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Dalton, Krista M., Coon, Colin, Greninger, Patricia, Egan, Regina K., Stein, Giovanna T., Murchie, Ellen, McClanaghan, Joseph, Adachi, Yuta, Hirade, Kentaro, Dozmorov, Mikhail, Glod, John, Boikos, Sosipatros A., Ebi, Hiromichi, Hao, Huaixiang, Caponigro, Giordano, Benes, Cyril H., Faber, Anthony C.
Published in Cell reports (Cambridge) (26.07.2022)
Published in Cell reports (Cambridge) (26.07.2022)
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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
HATA, Aaron N, YEO, Alan, MINO-KENUDSON, Mari, WONG, Kwok-Kin, ENGELMAN, Jeffrey A, FABER, Anthony C, LIFSHITS, Eugene, ZHAO CHEN, CHENG, Katherine A, WALTON, Zandra, SAROSIEK, Kristopher A, LETAI, Anthony, HEIST, Rebecca S
Published in Cancer research (Chicago, Ill.) (01.06.2014)
Published in Cancer research (Chicago, Ill.) (01.06.2014)
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