Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor
Miwa, Kazuhiro, Hitaka, Takenori, Imada, Takashi, Sasaki, Satoshi, Yoshimatsu, Mie, Kusaka, Masami, Tanaka, Akira, Nakata, Daisuke, Furuya, Shuichi, Endo, Satoshi, Hamamura, Kazumasa, Kitazaki, Tomoyuki
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy
Fujimura, Atsushi, Yasui, Seiji, Igawa, Kazuyo, Ueda, Ai, Watanabe, Kaori, Hanafusa, Tadashi, Ichikawa, Yasuaki, Yoshihashi, Sachiko, Tsuchida, Kazuki, Kamiya, Atsunori, Furuya, Shuichi
Published in Cells (Basel, Switzerland) (23.09.2020)
Published in Cells (Basel, Switzerland) (23.09.2020)
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Discovery of a Thieno[2,3-d]pyrimidine-2,4-dione Bearing a p-Methoxyureidophenyl Moiety at the 6-Position: A Highly Potent and Orally Bioavailable Non-Peptide Antagonist for the Human Luteinizing Hormone-Releasing Hormone Receptor
Sasaki, Satoshi, Cho, Nobuo, Nara, Yoshi, Harada, Masataka, Endo, Satoshi, Suzuki, Nobuhiro, Furuya, Shuichi, Fujino, Masahiko
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
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Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists
Yamamoto, Satoshi, Matsunaga, Nobuyuki, Hitaka, Takenori, Yamada, Masami, Hara, Takahito, Miyazaki, Junichi, Santou, Takashi, Kusaka, Masami, Yamaoka, Masuo, Kanzaki, Naoyuki, Furuya, Shuichi, Tasaka, Akihiro, Hamamura, Kazumasa, Ito, Mitsuhiro
Published in Bioorganic & medicinal chemistry (01.01.2012)
Published in Bioorganic & medicinal chemistry (01.01.2012)
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Suppression of a Pituitary-Ovarian Axis by Chronic Oral Administration of a Novel Nonpeptide Gonadotropin-Releasing Hormone Antagonist, TAK-013, in Cynomolgus Monkeys
Hara, Takahito, Araki, Hideo, Kusaka, Masami, Harada, Masataka, Cho, Nobuo, Suzuki, Nobuhiro, Furuya, Shuichi, Fujino, Masahiko
Published in The journal of clinical endocrinology and metabolism (01.04.2003)
Published in The journal of clinical endocrinology and metabolism (01.04.2003)
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Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT)
Michiue, Hiroyuki, Kitamatsu, Mizuki, Fukunaga, Asami, Tsuboi, Nobushige, Fujimura, Atsushi, Matsushita, Hiroaki, Igawa, Kazuyo, Kasai, Tomonari, Kondo, Natsuko, Matsui, Hideki, Furuya, Shuichi
Published in Journal of controlled release (10.02.2021)
Published in Journal of controlled release (10.02.2021)
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Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
Kaku, Tomohiro, Hitaka, Takenori, Ojida, Akio, Matsunaga, Nobuyuki, Adachi, Mari, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Okuda, Teruaki, Asahi, Satoru, Furuya, Shuichi, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.11.2011)
Published in Bioorganic & medicinal chemistry (01.11.2011)
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Discovery of 1-{4[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor
Miwa, Kazuhiro, Hitaka, Takenori, Imada, Takashi, Sasaki, Satoshi, Yoshimatsu, Mie, Kusaka, Masami, Tanaka, Akira, Nakata, Daisuke, Furuya, Shuichi, Endo, Satoshi, Hamamura, Kazumasa, Kitazaki, Tomoyuki
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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DDIS-20. NEW A6K BORON DRUG DELIVERY SYSTEM FOR CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT)
Michiue, Hiroyuki, Fukunaga, Asami, Fujimura, Atsushi, Igawa, Kazuyo, Matsui, Hideki, Furuya, Shuichi
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
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Particle and Heavy Ion Transport Code System‐Based Microdosimetry for the Development of Boron Agents for Boron Neutron Capture Therapy
Shigehira, Takafumi, Hanafusa, Tadashi, Igawa, Kazuyo, Kasai, Tomonari, Furuya, Shuichi, Nishimori, Hisakazu, Maeda, Yoshinobu, Michiue, Hiroyuki, Fujimura, Atsushi
Published in Advanced theory and simulations (01.07.2023)
Published in Advanced theory and simulations (01.07.2023)
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METHOD FOR ISOLATING STEM CELLS USING IN-VITRO BORON-NEUTRON REACTION
NISHITANI Takeo, Furuya Shuichi, MAEDA Yoshinobu, Ueda Ai, URITANI Akira, YOSHIHASHI Sachiko, KASAI Tomonari, TSUCHIDA Kazuki
Year of Publication 15.06.2023
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Year of Publication 15.06.2023
Patent
STEM CELL FRACTIONATION METHOD USING IN VITRO BORON NEUTRON REACTION
UEDA AI, KASAI TOMONARI, YOSHIHASHI SACHIKO, TSUCHIDA KAZUTERU, MAEDA YOSHINOBU, URITANI AKIRA, FURUYA SHUICHI, NISHITANI TAKEO
Year of Publication 20.06.2023
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Year of Publication 20.06.2023
Patent
NOVEL BSH COMPLEX FOR BORON NEUTRON CAPTURE THERAPY
TAKEUCHI, Yasuaki, MATSUI, Hideki, FURUYA, Shuichi, KAKUTA, Hiroki, MICHIUE, Hiroyuki
Year of Publication 31.05.2018
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Year of Publication 31.05.2018
Patent
Design, Synthesis, and Structure−Activity Relationships of Thieno[2,3-b]pyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists
Imada, Takashi, Cho, Nobuo, Imaeda, Toshihiro, Hayase, Yoji, Sasaki, Satoshi, Kasai, Shizuo, Harada, Masataka, Matsumoto, Hirokazu, Endo, Satoshi, Suzuki, Nobuhiro, Furuya, Shuichi
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor
Cho, Nobuo, Harada, Masataka, Imaeda, Toshihiro, Imada, Takashi, Matsumoto, Hirokazu, Hayase, Yoji, Sasaki, Satoshi, Furuya, Shuichi, Suzuki, Nobuhiro, Okubo, Shoichi, Ogi, Kazuhiro, Endo, Satoshi, Onda, Haruo, Fujino, Masahiko
Published in Journal of medicinal chemistry (22.10.1998)
Published in Journal of medicinal chemistry (22.10.1998)
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