Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.
Published in Nature (London) (01.06.2017)
Published in Nature (London) (01.06.2017)
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Journal Article
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (01.03.2018)
Published in Nature (London) (01.03.2018)
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Journal Article
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Mobbs, Jesse I, Belousoff, Matthew J, Harikumar, Kaleeckal G, Piper, Sarah J, Xu, Xiaomeng, Furness, Sebastian G B, Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M, Miller, Laurence J, Sexton, Patrick M
Published in PLoS biology (01.06.2021)
Published in PLoS biology (01.06.2021)
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Journal Article
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (16.01.2020)
Published in Nature (London) (16.01.2020)
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Journal Article
Structure and dynamics of the active Gs-coupled human secretin receptor
Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Published in Nature communications (18.08.2020)
Published in Nature communications (18.08.2020)
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Journal Article
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
Harikumar, Kaleeckal G, Zhao, Peishen, Cary, Brian P, Xu, Xiaomeng, Desai, Aditya J, Dong, Maoqing, Mobbs, Jesse I, Toufaily, Chirine, Furness, Sebastian G B, Christopoulos, Arthur, Belousoff, Matthew J, Wootten, Denise, Sexton, Patrick M, Miller, Laurence J
Published in PLoS biology (31.07.2024)
Published in PLoS biology (31.07.2024)
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Journal Article
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias
Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G, Sexton, Patrick M, Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim
Published in PloS one (18.03.2014)
Published in PloS one (18.03.2014)
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Journal Article
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins
Liang, Yi-Lynn, Belousoff, Matthew J, Fletcher, Madeleine M, Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B, Miller, Laurence J, Hay, Debbie L, Christopoulos, Arthur, Reynolds, Christopher A, Danev, Radostin, Wootten, Denise, Sexton, Patrick M
Published in ACS pharmacology & translational science (10.04.2020)
Published in ACS pharmacology & translational science (10.04.2020)
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Journal Article
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
Ostrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S, Stringer, Brett W, Wookey, Peter J, Wootten, Denise, Sexton, Patrick M, Furness, Sebastian G B
Published in BMC cancer (18.02.2019)
Published in BMC cancer (18.02.2019)
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Journal Article
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination
Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T, May, Lauren T, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M, Furness, Sebastian G. B
Published in ACS pharmacology & translational science (14.09.2018)
Published in ACS pharmacology & translational science (14.09.2018)
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Journal Article
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Cook, A E, Mistry, S N, Gregory, K J, Furness, S G B, Sexton, P M, Scammells, P J, Conigrave, A D, Christopoulos, A, Leach, K
Published in British journal of pharmacology (01.01.2015)
Published in British journal of pharmacology (01.01.2015)
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Journal Article
Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors
Morfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B, Christopoulos, George, Werry, Tim D, Christopoulos, Arthur, Sexton, Patrick M
Published in Endocrinology (Philadelphia) (01.11.2008)
Published in Endocrinology (Philadelphia) (01.11.2008)
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Journal Article
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
Harikumar, Kaleeckal G, Wootten, Denise, Pinon, Delia I, Koole, Cassandra, Ball, Alicja M, Furness, Sebastian G. B, Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J, Sexton, Patrick M
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2012)
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Journal Article
Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers
Furness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A., Furness, Sebastian G. B.
Published in Neurogastroenterology and motility (01.05.2021)
Published in Neurogastroenterology and motility (01.05.2021)
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Journal Article
Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma
Gilabert-Oriol, Roger, Furness, Sebastian G. B., Stringer, Brett W., Weng, Alexander, Fuchs, Hendrik, Day, Bryan W., Kourakis, Angela, Boyd, Andrew W., Hare, David L., Thakur, Mayank, Johns, Terrance G., Wookey, Peter J.
Published in Cancer Immunology, Immunotherapy (01.09.2017)
Published in Cancer Immunology, Immunotherapy (01.09.2017)
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Journal Article
TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum
Nguyen, Huynh T H, Wood, Rhiannon J, Prawdiuk, Alexa R, Furness, Sebastian G B, Xiao, Junhua, Murray, Simon S, Fletcher, Jessica L
Published in Frontiers in molecular neuroscience (27.08.2019)
Published in Frontiers in molecular neuroscience (27.08.2019)
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Journal Article
The Molecular Control of Calcitonin Receptor Signaling
dal Maso, Emma, Glukhova, Alisa, Zhu, Yue, Garcia-Nafria, Javier, Tate, Christopher G, Atanasio, Silvia, Reynolds, Christopher A, Ramírez-Aportela, Erney, Carazo, Jose-Maria, Hick, Caroline A, Furness, Sebastian G. B, Hay, Debbie L, Liang, Yi-Lynn, Miller, Laurence J, Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M
Published in ACS pharmacology & translational science (08.02.2019)
Published in ACS pharmacology & translational science (08.02.2019)
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Journal Article
Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L., Wookey, Peter J.
Published in Therapeutic Advances in Medical Oncology (2020)
Published in Therapeutic Advances in Medical Oncology (2020)
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Book Review
Journal Article
Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol
Harikumar, Kaleeckal G, Coudrat, Thomas, Desai, Aditya J, Dong, Maoqing, Dengler, Daniela G, Furness, Sebastian G B, Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A, Sexton, Patrick M, Miller, Laurence J
Published in Frontiers in endocrinology (Lausanne) (07.12.2021)
Published in Frontiers in endocrinology (Lausanne) (07.12.2021)
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