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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA
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Published in Science (American Association for the Advancement of Science) (03.01.2014)
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EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
Liu, Feng, Hon, Gary C., Villa, Genaro R., Turner, Kristen M., Ikegami, Shiro, Yang, Huijun, Ye, Zhen, Li, Bin, Kuan, Samantha, Lee, Ah Young, Zanca, Ciro, Wei, Bowen, Lucey, Greg, Jenkins, David, Zhang, Wei, Barr, Cathy L., Furnari, Frank B., Cloughesy, Timothy F., Yong, William H., Gahman, Timothy C., Shiau, Andrew K., Cavenee, Webster K., Ren, Bing, Mischel, Paul S.
Published in Molecular cell (15.10.2015)
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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.
Published in Cancer cell (09.07.2018)
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MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells
Talukdar, Sarmistha, Pradhan, Anjan K., Bhoopathi, Praveen, Shen, Xue-Ning, August, Laura A., Windle, Jolene J., Sarkar, Devanand, Furnari, Frank B., Cavenee, Webster K., Das, Swadesh K., Emdad, Luni, Fisher, Paul B.
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2018)
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Malignant astrocytic glioma: genetics, biology, and paths to treatment
Furnari, Frank B, Fenton, Tim, Bachoo, Robert M, Mukasa, Akitake, Stommel, Jayne M, Stegh, Alexander, Hahn, William C, Ligon, Keith L, Louis, David N, Brennan, Cameron, Chin, Lynda, DePinho, Ronald A, Cavenee, Webster K
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PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
Benitez, Jorge A., Ma, Jianhui, D’Antonio, Matteo, Boyer, Antonia, Camargo, Maria Fernanda, Zanca, Ciro, Kelly, Stephen, Khodadadi-Jamayran, Alireza, Jameson, Nathan M., Andersen, Michael, Miletic, Hrvoje, Saberi, Shahram, Frazer, Kelly A., Cavenee, Webster K., Furnari, Frank B.
Published in Nature communications (12.05.2017)
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Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin
Kegelman, Timothy P., Wu, Bainan, Das, Swadesh K., Talukdar, Sarmistha, Beckta, Jason M., Hu, Bin, Emdad, Luni, Valerie, Kristoffer, Sarkar, Devanand, Furnari, Frank B., Cavenee, Webster K., Wei, Jun, Purves, Angela, De, Surya K., Pellecchia, Maurizio, Fisher, Paul B.
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2017)
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The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)
Tsuchihashi, Kenji, Okazaki, Shogo, Ohmura, Mitsuyo, Ishikawa, Miyuki, Sampetrean, Oltea, Onishi, Nobuyuki, Wakimoto, Hiroaki, Yoshikawa, Momoko, Seishima, Ryo, Iwasaki, Yoshimi, Morikawa, Takayuki, Abe, Shinya, Takao, Ayumi, Shimizu, Misato, Masuko, Takashi, Nagane, Motoo, Furnari, Frank B, Akiyama, Tetsu, Suematsu, Makoto, Baba, Eishi, Akashi, Koichi, Saya, Hideyuki, Nagano, Osamu
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YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity
Yu, Olivia M., Benitez, Jorge A., Plouffe, Steven W., Ryback, Daniel, Klein, Andrea, Smith, Jeff, Greenbaum, Jason, Delatte, Benjamin, Rao, Anjana, Guan, Kun-Liang, Furnari, Frank B., Chaim, Olga Meiri, Miyamoto, Shigeki, Brown, Joan Heller
Published in Oncogene (01.10.2018)
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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
Bi, Junfeng, Khan, Atif, Tang, Jun, Armando, Aaron M., Wu, Sihan, Zhang, Wei, Gimple, Ryan C., Reed, Alex, Jing, Hui, Koga, Tomoyuki, Wong, Ivy Tsz-Lo, Gu, Yuchao, Miki, Shunichiro, Yang, Huijun, Prager, Briana, Curtis, Ellis J., Wainwright, Derek A., Furnari, Frank B., Rich, Jeremy N., Cloughesy, Timothy F., Kornblum, Harley I., Quehenberger, Oswald, Rzhetsky, Andrey, Cravatt, Benjamin F., Mischel, Paul S.
Published in Cell reports (Cambridge) (02.11.2021)
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Quantitative Analysis of EGFRvIII Cellular Signaling Networks Reveals a Combinatorial Therapeutic Strategy for Glioblastoma
Huang, Paul H., Mukasa, Akitake, Bonavia, Rudy, Flynn, Ryan A., Brewer, Zachary E., Cavenee, Webster K., Furnari, Frank B., White, Forest M.
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2007)
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MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression
Wang, Yemin, Huang, Jen-Wei, Li, Ming, Cavenee, Webster K, Mitchell, Patrick S, Zhou, Xiaofeng, Tewari, Muneesh, Furnari, Frank B, Taniguchi, Toshiyasu
Published in Molecular cancer research (01.08.2011)
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Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Koga, Tomoyuki, Chaim, Isaac A., Benitez, Jorge A., Markmiller, Sebastian, Parisian, Alison D., Hevner, Robert F., Turner, Kristen M., Hessenauer, Florian M., D’Antonio, Matteo, Nguyen, Nam-phuong D., Saberi, Shahram, Ma, Jianhui, Miki, Shunichiro, Boyer, Antonia D., Ravits, John, Frazer, Kelly A., Bafna, Vineet, Chen, Clark C., Mischel, Paul S., Yeo, Gene W., Furnari, Frank B.
Published in Nature communications (28.01.2020)
Published in Nature communications (28.01.2020)
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Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion
Chaim, Olga Meiri, Miki, Shunichiro, Prager, Briana C., Ma, Jianhui, Jeong, Anthony Y., Lara, Jacqueline, Tran, Nancy K., Smith, Jeffrey M., Rich, Jeremy N., Gutkind, J. Silvio, Miyamoto, Shigeki, Furnari, Frank B., Brown, Joan Heller
Published in Scientific reports (16.12.2023)
Published in Scientific reports (16.12.2023)
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A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma
Read, Renee D, Fenton, Tim R, Gomez, German G, Wykosky, Jill, Vandenberg, Scott R, Babic, Ivan, Iwanami, Akio, Yang, Huijun, Cavenee, Webster K, Mischel, Paul S, Furnari, Frank B, Thomas, John B
Published in PLoS genetics (01.02.2013)
Published in PLoS genetics (01.02.2013)
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Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
Sok, John C, Coppelli, Francesca M, Thomas, Sufi M, Lango, Miriam N, Xi, Sichuan, Hunt, Jennifer L, Freilino, Maria L, Graner, Michael W, Wikstrand, Carol J, Bigner, Darell D, Gooding, William E, Furnari, Frank B, Grandis, Jennifer R
Published in Clinical cancer research (01.09.2006)
Published in Clinical cancer research (01.09.2006)
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