Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine
Fukumoto, Kenichi, Iijima, Michihiko, Funakoshi, Takeo, Chaki, Shigeyuki
Published in The international journal of neuropsychopharmacology (01.04.2018)
Published in The international journal of neuropsychopharmacology (01.04.2018)
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Antidepressant/anxiolytic potential and adverse effect liabilities of melanin-concentrating hormone receptor 1 antagonists in animal models
Chaki, Shigeyuki, Shimazaki, Toshiharu, Nishiguchi, Mariko, Funakoshi, Takeo, Iijima, Michihiko, Ito, Akie, Kanuma, Kosuke, Sekiguchi, Yoshinori
Published in Pharmacology, biochemistry and behavior (01.08.2015)
Published in Pharmacology, biochemistry and behavior (01.08.2015)
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Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
Chaki, Shigeyuki, Funakoshi, Takeo, Hirota-Okuno, Shiho, Nishiguchi, Mariko, Shimazaki, Toshiharu, Iijima, Michihiko, Grottick, Andrew J, Kanuma, Kosuke, Omodera, Katsunori, Sekiguchi, Yoshinori, Okuyama, Shigeru, Tran, Thuy-Anh, Semple, Graeme, Thomsen, William
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
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Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor
Chaki, Shigeyuki, Hirota, Shiho, Funakoshi, Takeo, Suzuki, Yoshiko, Suetake, Sayoko, Okubo, Taketoshi, Ishii, Takaaki, Nakazato, Atsuro, Okuyama, Shigeru
Published in The Journal of pharmacology and experimental therapeutics (01.02.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2003)
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Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents
CHAKI, Shigeyuki, OGAWA, Shin-Ichi, TODA, Yoshihisa, FUNAKOSHI, Takeo, OKUYAMA, Shigeru
Published in European journal of pharmacology (01.08.2003)
Published in European journal of pharmacology (01.08.2003)
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Binding characteristics of [formula omitted]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors
Chaki, Shigeyuki, Funakoshi, Takeo, Yoshikawa, Ryoko, Okuyama, Shigeru, Okubo, Taketoshi, Nakazato, Atsuro, Nagamine, Masashi, Tomisawa, Kazuyuki
Published in European journal of pharmacology (29.04.1999)
Published in European journal of pharmacology (29.04.1999)
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A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile
Okuyama, S, Kawashima, N, Chaki, S, Yoshikawa, R, Funakoshi, T, Ogawa, S I, Suzuki, Y, Ikeda, Y, Kumagai, T, Nakazato, A, Nagamine, M, Tomisawa, K
Published in Life sciences (1973) (01.10.1999)
Published in Life sciences (1973) (01.10.1999)
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MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity
Chaki, Shigeyuki, Oshida, Yuichi, Ogawa, Shin-ichi, Funakoshi, Takeo, Shimazaki, Toshiharu, Okubo, Taketoshi, Nakazato, Atsuro, Okuyama, Shigeru
Published in Pharmacology, biochemistry and behavior (01.12.2005)
Published in Pharmacology, biochemistry and behavior (01.12.2005)
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Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists
Kanuma, Kosuke, Omodera, Katsunori, Nishiguchi, Mariko, Funakoshi, Takeo, Chaki, Shigeyuki, Nagase, Yasuko, Iida, Izumi, Yamaguchi, Jun-ichi, Semple, Graeme, Tran, Thuy-Anh, Sekiguchi, Yoshinori
Published in Bioorganic & medicinal chemistry (15.05.2006)
Published in Bioorganic & medicinal chemistry (15.05.2006)
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Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1
Kanuma, Kosuke, Omodera, Katsunori, Nishiguchi, Mariko, Funakoshi, Takeo, Chaki, Shigeyuki, Semple, Graeme, Tran, Thuy-Anh, Kramer, Bryan, Hsu, Debbie, Casper, Martin, Thomsen, Bill, Sekiguchi, Yoshinori
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
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Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1
Kanuma, Kosuke, Omodera, Katsunori, Nishiguchi, Mariko, Funakoshi, Takeo, Chaki, Shigeyuki, Semple, Graeme, Tran, Thuy-Anh, Kramer, Bryan, Hsu, Debbie, Casper, Martin, Thomsen, Bill, Beeley, Nigel, Sekiguchi, Yoshinori
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Antipsychotic profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562) in rats
Takamori, Kazuaki, Funakoshi, Takeo, Hirota, Shiho, Chaki, Shigeyuki, Kameo, Kazuya
Published in Life sciences (1973) (12.07.2002)
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Published in Life sciences (1973) (12.07.2002)
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Interaction of tyrosine 65 of RecA protein with the first and second DNA strands
Morimatsu, Katsumi, Funakoshi, Takeo, Horii, Toshihiro, Takahashi, Masayuki
Published in Journal of molecular biology (16.02.2001)
Published in Journal of molecular biology (16.02.2001)
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In vitro and in vivo receptor binding profile of NRA0161 and NRA0562, novel atypical antipsychotics
Funakoshi, Takeo, Chaki, Shigeyuki, Yoshikakwa, Ryoko, Okuyama, Shigeru, Nakazato, Atsuro, Kumagai, Toshihito, Nagamine, Masashi, Tomisawa, Kazuyuki
Published in Japanese Journal of Pharmacology (1999)
Published in Japanese Journal of Pharmacology (1999)
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