MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM
Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2019)
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Journal Article
683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Zhu, Eric, Blom, Daniel, Sethumadhavan, Shalini, Merriman, Chengfeng, Molloy, Katherine, Fink, Alexandria, Lou, Shan, Rogantino, Andrew, Apte, Ameya, abbassi, Mandana, Liao, Tiffany, Dai, Hongyue, Fulgham, Aaron, Hurov, Jonathan, Huang, Pearl
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation
SCHOEBERL, Birgit, FABER, Anthony C, FULGHAM, Aaron, SONG, Youngchul, NIELSEN, Ulrik B, ENGELMAN, Jeffrey A, WONG, Kwok-Kin, DANAN LI, LIANG, Mei-Chih, CROSBY, Katherine, ONSUM, Matthew, BURENKOVA, Olga, PACE, Emily, WALTON, Zandra, LIN NIE
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Published in Cancer research (Chicago, Ill.) (15.03.2010)
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Abstract LB-C05: The autism and schizophrenia-associated CYFIP1 protein is required for pancreatic tumor growth and presents a potential therapeutic target
Couto, Kiley, Strickland, Matthew, Liao, Tiffany, Najem, Mortada, Fulgham, Aaron, Apte, Ameya, Huang, Pearl, Hurov, Jonathan, Lantermann, Alexandra
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract 526: Novel mechanisms of Neuropilin-1 inhibition result in improved tumor growth inhibition in vivo
Sethumadhavan, Shalini, Zhu, Eric, Fulgham, Aaron, Abbassi, Mandana, Apte, Ameya, Liao, Tiffany, Merriman, Chengfeng, Molloy, Katherine, Stein, Caitlin, Hanna, Amber, Geoghegan, James, Prinz, Bianka, Dai, Hongyue, Hurov, Jonathan, Huang, Pearl, Blom, Daniel
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 1690: Mechanistic characterization of MM-131, a bispecific antibody that blocks c-Met signaling through concurrent targeting of EpCAM
Abu-Yousif, Adnan O., Casaletto, Jessica B., Masson, Kristina, Fulgham, Aaron, Geddie, Melissa, Schoeberl, Birgit, Nielsen, Ulrik, MacBeath, Gavin
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
Schoeberl, Birgit, Kudla, Art, Masson, Kristina, Kalra, Ashish, Curley, Michael, Finn, Gregory, Pace, Emily, Harms, Brian, Kim, Jaeyeon, Kearns, Jeff, Fulgham, Aaron, Burenkova, Olga, Grantcharova, Viara, Yarar, Defne, Paragas, Violette, Fitzgerald, Jonathan, Wainszelbaum, Marisa, West, Kip, Mathews, Sara, Nering, Rachel, Adiwijaya, Bambang, Garcia, Gabriela, Kubasek, Bill, Moyo, Victor, Czibere, Akos, Nielsen, Ulrik B, MacBeath, Gavin
Published in NPJ systems biology and applications (01.01.2017)
Published in NPJ systems biology and applications (01.01.2017)
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Abstract 166: Identification of Grk2 as novel oncology target and development of potent Grk2 inhibitors
Lantermann, Alexandra, Chekler, Eugene, Lefker, Bruce, Yuen, Garmen, Lam, Vanessa, Strickland, Matthew, Pennacchio, Justyne, Fulgham, Aaron, Bree, Dara, Perekslis, Thomas, Piizzi, Grazia, Dai, Hongyue, Zheng, Tim, Wagner, John, Huang, Pearl
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 3094: Discovery of a HeliconTM peptide inhibitor of the beta-catenin-TCF interaction with in vivo activity
White, Brian H., Si, Yaguang, Cappucci, Sarah, Li, Zhi, Ramirez, Jessica D., Ponthier, Charles M., Visness, Erica, Du, Peicheng, Choi, Minjung, Beerepoot, Pieter C., Ortet, Paula C., Jewett, Ivan T., Alfaro-Lopez, Josue, Agarwal, Sorabh, La, Daniel, Fulgham, Aaron, McGee, John H., Orford, Keith, Hurov, Jonathan B., Tremblay, Martin R., Verdine, Gregory L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4972: Anti-tumor activity of Helicon inhibitors of Β-catenin-TCF interaction in patient-derived xenograft models
Si, YaGuang, Choi, Minjung, Han, Xinwei, White, Brian, Wu, Ziyang, Visness, Erica, Beerepoot, Pieter, Jaensch, Elizabeth, Ramirez, Jessica, Ponthier, Charles, Han, Xiaogang, Ortet, Paula, Du, Peicheng, Agarwal, Sorabh, Lech, Mirek, Fulgham, Aaron, Cappucci, Sarah, Li, Zhi, McGee, John, Yu, Lihua, Tremblay, Martin, Orford, Keith, Verdine, Gregory, Hurov, Jonathan
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract PR9: Investigating combinatorial ligand addiction provides insights into rational drug combinations in cancer therapy
Pace, Emily A., Nielsen, Ulrik B., Schoeberl, Birgit, Chai, Diana H., Parikh, Anand, Kalra, Ashish, Oyama, Shinji, Johnson, Bryan, Tan, Gege, Fulgham, Aaron, Bukhalid, Raghida
Published in Cancer research (Chicago, Ill.) (01.07.2012)
Published in Cancer research (Chicago, Ill.) (01.07.2012)
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Abstract 1806: Efficacy of MM121 in ER+ and triple negative breast cancer studies
Nie, Lin, Burenkova, Olga, Adams, Sharlene, Kalra, Ashish, Fulgham, Aaron, Xiao, Dongmei, Grantcharova, Viara, Onsum, Matt, Wille, Lucia, Moulis, Sharon, Garcia, Gabriela, Moyo, Victor, Kubasek, Bill, Nielsen, Ulrik
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract 3756: Prediction of xenograft response to MM-121, an anti-ErbB3 inhibitor, using computational modeling and measurements of five biomarkers
Onsum, Matthew, Burenkova, Olga, Fulgham, Aaron, Nie, Lin, Kalra, Ashish, Xiao, Dongmei, Grantcharova, Viara, Adams, Sharlene, Luus, Lia, Paragas, Violette, Bukhalid, Raghida, Moulis, Sharon, Wille, Lucia, Garcia, Gabriela, Moyo, Victor, Schoeberl, Birgit, Kubasek, Bill, Nielsen, Ulrik
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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