AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist
Fukushima-Shintani, Mari, Suzuki, Ken-ichi, Iwatsuki, Yoshiyuki, Abe, Masaki, Sugasawa, Keizo, Hirayama, Fukushi, Kawasaki, Tomihisa, Nakahata, Tatsutoshi
Published in European journal of haematology (01.04.2009)
Published in European journal of haematology (01.04.2009)
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Journal Article
Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands
Miura, Masanori, Seki, Norio, Koike, Takanori, Ishihara, Tsukasa, Niimi, Tatsuya, Hirayama, Fukushi, Shigenaga, Takeshi, Sakai-Moritani, Yumiko, Tagawa, Ayako, Kawasaki, Tomihisa, Sakamoto, Shuichi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (2007)
Published in Bioorganic & medicinal chemistry (2007)
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Journal Article
Biochemical and pharmacological characterization of YM-60828, a newly synthesized and orally active inhibitor of human factor Xa
Taniuchi, Y, Sakai, Y, Hisamichi, N, Kayama, M, Mano, Y, Sato, K, Hirayama, F, Koshio, H, Matsumoto, Y, Kawasaki, T
Published in Thrombosis and haemostasis (01.03.1998)
Published in Thrombosis and haemostasis (01.03.1998)
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Journal Article
Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors
Koshio, Hiroyuki, Hirayama, Fukushi, Ishihara, Tsukasa, Shiraki, Ryouta, Shigenaga, Takeshi, Taniuchi, Yuta, Sato, Kazuo, Moritani, Yumiko, Iwatsuki, Yoshiyuki, Kaku, Seiji, Katayama, Naoko, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.02.2005)
Published in Bioorganic & medicinal chemistry (15.02.2005)
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Journal Article
The discovery of YM-60828: A potent, selective and orally-bioavailable factor Xa inhibitor
HIRAYAMA, Fukushi, KOSHIO, Hiroyuki, YANAGISAWA, Isao, KATAYAMA, Naoko, KURIHARA, Hiroyuki, TANIUCHI, Yuta, SATO, Kazuo, HISAMICHI, Nami, SAKAI-MORITANI, Yumiko, KAWASAKI, Tomihisa, MATSUMOTO, Yuzo
Published in Bioorganic & medicinal chemistry (01.05.2002)
Published in Bioorganic & medicinal chemistry (01.05.2002)
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Journal Article
YM-60828, a novel factor Xa inhibitor: Separation of its antithrombotic effects from its prolongation of bleeding time
Sato, Kazuo, Kawasaki, Tomihisa, Taniuchi, Yuta, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo
Published in European journal of pharmacology (27.11.1997)
Published in European journal of pharmacology (27.11.1997)
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Journal Article
An Easy Access to 7-Methyl-2-naphthalenecarbonitrile
Koshio, Hiroyuki, Ishihara, Tsukasa, Yamada, Hiroyoshi, Hirayama, Fukushi, Matsumoto, Yuzo, Yanagisawa, Isao
Published in Chemical & Pharmaceutical Bulletin (01.04.2005)
Published in Chemical & Pharmaceutical Bulletin (01.04.2005)
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Journal Article
Antithrombotic effects of YM‐60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time
Sato, Kazuo, Kawasaki, Tomihisa, Hisamichi, Nami, Taniuchi, Yuta, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo
Published in British journal of pharmacology (01.01.1998)
Published in British journal of pharmacology (01.01.1998)
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Journal Article
Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives
Koshio, Hiroyuki, Hirayama, Fukushi, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Shigenaga, Takeshi, Taniuchi, Yuta, Sato, Kazuo, Moritani, Yumiko, Iwatsuki, Yoshiyuki, Uemura, Toshio, Kaku, Seiji, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.10.2004)
Published in Bioorganic & medicinal chemistry (15.10.2004)
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Journal Article
Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template
Hirayama, Fukushi, Koshio, Hiroyuki, Katayama, Naoko, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Taniuchi, Yuta, Sato, Kazuo, Sakai-Moritani, Yumiko, Kaku, Seiji, Kurihara, Hiroyuki, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (06.02.2003)
Published in Bioorganic & medicinal chemistry (06.02.2003)
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Journal Article
Design, synthesis and biological activity of YM-60828 derivatives: Potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates
HIRAYAMA, Fukushi, KOSHIO, Hiroyuki, SATO, Kazuo, SAKAI-MORITANI, Yumiko, KAKU, Seiji, KAWASAKI, Tomihisa, MATSUMOTO, Yuzo, SAKAMOTO, Shuichi, TSUKAMOTO, Shin-Ichi, ISHIHARA, Tsukasa, WATANUKI, Susumu, HACHIYA, Shunichiro, KAIZAWA, Hiroyuki, KURAMOCHI, Takahiro, KATAYAMA, Naoko, KURIHARA, Hiroyuki, TANIUCHI, Yuta
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis
Kawasaki, T, Sato, K, Sakai, Y, Hirayama, F, Koshio, H, Taniuchi, Y, Matsumoto, Y
Published in Thrombosis and haemostasis (01.02.1998)
Published in Thrombosis and haemostasis (01.02.1998)
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Journal Article
Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats
Sato, Kazuo, Taniuchi, Yuta, Kawasaki, Tomihisa, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo
Published in European journal of pharmacology (24.04.1998)
Published in European journal of pharmacology (24.04.1998)
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Journal Article
Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system
Ishihara, Tsukasa, Koga, Yuji, Iwatsuki, Yoshiyuki, Hirayama, Fukushi
Published in Bioorganic & medicinal chemistry (15.01.2015)
Published in Bioorganic & medicinal chemistry (15.01.2015)
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Journal Article
Effect of a synthetic factor Xa inhibitor, YM-60828, on blood vessel patency in combination with a thrombolytic agent and on blood loss from the operation site in a rat model of arterial thrombosis
Kawasaki, T, Sato, K, Hirayama, F, Koshio, H, Taniuchi, Y, Matsumoto, Y
Published in Thrombosis and haemostasis (01.04.1998)
Published in Thrombosis and haemostasis (01.04.1998)
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Journal Article
Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs
Sato, Kazuo, Kawasaki, Tomihisa, Hisamichi, Nami, Taniuchi, Yuta, Hirayama, Fukushi, Koshio, Hiroyuki, Ichihara, Masato, Matsumoto, Yuzo
Published in European journal of pharmacology (29.05.1998)
Published in European journal of pharmacology (29.05.1998)
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Journal Article
Antithrombotic effect of YM-75466 is separated from its effect on bleeding time and coagulation time
Sato, Kazuo, Kaku, Seiji, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo, Kawasaki, Tomihisa, Iizumi, Yuichi
Published in European journal of pharmacology (03.07.1998)
Published in European journal of pharmacology (03.07.1998)
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Journal Article
Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates
Ishihara, Tsukasa, Koga, Yuji, Mori, Kenichi, Sugasawa, Keizo, Iwatsuki, Yoshiyuki, Hirayama, Fukushi
Published in Bioorganic & medicinal chemistry (15.11.2014)
Published in Bioorganic & medicinal chemistry (15.11.2014)
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Journal Article
Antithrombotic effects of YM466, a synthesized direct inhibitor of factor Xa, in an arterio-venous shunt thrombosis model in squirrel monkeys
Iwatsuki, Yoshiyuki, Kaku, Seiji, Moritani, Yumiko, Taniuchi, Yuta, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo, Mano, Yuji, Kawasaki, Tomihisa
Published in Drug development research (01.02.2003)
Published in Drug development research (01.02.2003)
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