Cooperative Therapeutic Action of Retinoic Acid Receptor and Retinoid X Receptor Agonists in a Mouse Model of Alzheimer's Disease
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Published in Journal of Alzheimer's disease (01.01.2014)
Published in Journal of Alzheimer's disease (01.01.2014)
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Transdermal Administration of Aqueous Pregabalin Solution as a Potential Treatment Option for Patients with Neuropathic Pain to Avoid Central Nervous System-Mediated Side Effects
Fukasawa, Hiroshi, Muratake, Hideaki, Nagae, Marina, Sugiyama, Kiyoshi, Shudo, Koichi
Published in Biological & pharmaceutical bulletin (01.11.2014)
Published in Biological & pharmaceutical bulletin (01.11.2014)
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Aldosterone-induced kidney injury is mediated by NFκB activation
Fukuda, Seiichi, Horimai, Chihiro, Harada, Kaori, Wakamatsu, Toshifumi, Fukasawa, Hiroshi, Muto, Susumu, Itai, Akiko, Hayashi, Matsuhiko
Published in Clinical and experimental nephrology (01.02.2011)
Published in Clinical and experimental nephrology (01.02.2011)
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(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
Muratake, Hideaki, Ito, Ai, Toda, Takahiro, Suzuki, Hideyuki, Fukasawa, Hiroshi, Tsuda, Makoto, Inoue, Kazuhide, Sugiyama, Kiyoshi, Shudo, Koichi
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Silicon-Containing GABA Derivatives, Silagaba Compounds, as Orally Effective Agents for Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects
Fukasawa, Hiroshi, Muratake, Hideaki, Ito, Ai, Suzuki, Hideyuki, Amano, Yohei, Nagae, Marina, Sugiyama, Kiyoshi, Shudo, Koichi
Published in ACS chemical neuroscience (16.07.2014)
Published in ACS chemical neuroscience (16.07.2014)
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Novel Retinoid X Receptor Antagonists: Specific Inhibition of Retinoid Synergism in RXR−RAR Heterodimer Actions
Takahashi, Bitoku, Ohta, Kiminori, Kawachi, Emiko, Fukasawa, Hiroshi, Hashimoto, Yuichi, Kagechika, Hiroyuki
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Transdermal Administration of Aqueous Pregabalin Solution as a Potential Treatment Option for Patients with Neuropathic Pain to Avoid Central Nervous System-Mediated Side Effects
Hiroshi Fukasawa, Hideaki Muratake, Marina Nagae, Kiyoshi Sugiyama, Koichi Shudo
Published in Biological and Pharmaceutical Bulletin (01.11.2014)
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Published in Biological and Pharmaceutical Bulletin (01.11.2014)
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Regulation of Retinoidal Actions by Diazepinylbenzoic Acids. Retinoid Synergists Which Activate the RXR−RAR Heterodimers
Umemiya, Hiroki, Fukasawa, Hiroshi, Ebisawa, Masayuki, Eyrolles, Laurence, Kawachi, Emiko, Eisenmann, Ghislaine, Gronemeyer, Hinrich, Hashimoto, Yuichi, Shudo, Koichi, Kagechika, Hiroyuki
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids
EBISAWA, Masayuki, UMEMIYA, Hiroki, OHTA, Kiminori, FUKASAWA, Hiroshi, KAWACHI, Emiko, CHRISTOFFEL, Ghislaine, GRONEMEYER, Hinrich, TSUJI, Motonori, HASHIMOTO, Yuichi, SHUDO, Koichi, KAGECHIKA, Hiroyuki
Published in Chemical & pharmaceutical bulletin (01.12.1999)
Published in Chemical & pharmaceutical bulletin (01.12.1999)
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Retinoidal Pyrimidinecarboxylic Acids. Unexpected Diaza-Substituent Effects in Retinobenzoic Acids
OHTA, Kiminori, KAWACHI, Emiko, INOUE, Noriko, FUKASAWA, Hiroshi, HASHIMOTO, Yuichi, ITAI, Akiko, KAGECHIKA, Hiroyuki
Published in Chemical & pharmaceutical bulletin (01.10.2000)
Published in Chemical & pharmaceutical bulletin (01.10.2000)
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Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4‑(1-Pyrrolidinyl)piperidine Structure
Kato, Terukazu, Fukao, Keita, Ohara, Takafumi, Naya, Noriyuki, Tokuyama, Ryukou, Muto, Susumu, Fukasawa, Hiroshi, Itai, Akiko, Matsumura, Ken-ichi
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
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Discovery and structure-based design of a new series of potent and selective PPAR6 agonists utilizing a virtual screening method
Kato, Terukazu, Ohara, Takafumi, Suzuki, Naoyuki, Muto, Susumu, Tokuyama, Ryukou, Mizutani, Miho, Fukasawa, Hiroshi, Matsumura, Ken-ichi, Itai, Akiko
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Discovery and structure-activity relationship study of 2-piperazinyl-benzo- thiazole derivatives as potent and selective PPAR delta; agonists
Kato, Terukazu, Ohara, Takafumi, Suzuki, Naoyuki, Naya, Noriyuki, Fukao, Keita, Tokuyama, Ryukou, Muto, Susumu, Fukasawa, Hiroshi, Itai, Akiko, Matsumura, Ken-ichi
Published in Bioorganic & medicinal chemistry (15.03.2023)
Published in Bioorganic & medicinal chemistry (15.03.2023)
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Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbA1c Values
Yamakoshi, Yuko, Fukasawa, Hiroshi, Yamauchi, Toshimasa, Waki, Hironori, Kadowaki, Takashi, Shudo, Koichi, Kagechika, Hiroyuki
Published in Biological & pharmaceutical bulletin (01.10.2002)
Published in Biological & pharmaceutical bulletin (01.10.2002)
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Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists
Kato, Terukazu, Ohara, Takafumi, Suzuki, Naoyuki, Naya, Noriyuki, Fukao, Keita, Tokuyama, Ryukou, Muto, Susumu, Fukasawa, Hiroshi, Itai, Akiko, Matsumura, Ken-ichi
Published in Bioorganic & medicinal chemistry (15.03.2023)
Published in Bioorganic & medicinal chemistry (15.03.2023)
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