Design of an in vitro biocatalytic cascade for the manufacture of islatravir
Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao
Published in Science (American Association for the Advancement of Science) (06.12.2019)
Published in Science (American Association for the Advancement of Science) (06.12.2019)
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Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site‐Saturated Libraries
Hulley, Martyn E, Toogood, Helen S, Fryszkowska, Anna, Mansell, David, Stephens, Gill M, Gardiner, John M, Scrutton, Nigel S
Published in Chembiochem : a European journal of chemical biology (22.11.2010)
Published in Chembiochem : a European journal of chemical biology (22.11.2010)
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Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
McIntosh, John A, Benkovics, Tamas, Silverman, Steven M, Huffman, Mark A, Kong, Jongrock, Maligres, Peter E, Itoh, Tetsuji, Yang, Hao, Verma, Deeptak, Pan, Weilan, Ho, Hsing-I, Vroom, Jonathan, Knight, Anders M, Hurtak, Jessica A, Klapars, Artis, Fryszkowska, Anna, Morris, William J, Strotman, Neil A, Murphy, Grant S, Maloney, Kevin M, Fier, Patrick S
Published in ACS central science (22.12.2021)
Published in ACS central science (22.12.2021)
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Studies on enzymatic synthesis of chiral non-racemic 3-arylglutaric acid monoesters
Fryszkowska, Anna, Komar, Marta, Koszelewski, Dominik, Ostaszewski, Ryszard
Published in Tetrahedron: asymmetry (20.03.2006)
Published in Tetrahedron: asymmetry (20.03.2006)
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Electrochemical Activation of Galactose Oxidase: Mechanistic Studies and Synthetic Applications
Zhang, Shaoguang, Ruccolo, Serge, Fryszkowska, Anna, Klapars, Artis, Marshall, Nicholas, Strotman, Neil A
Published in ACS catalysis (18.06.2021)
Published in ACS catalysis (18.06.2021)
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Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone
Patel, Niki R., Nawrat, Christopher C., McLaughlin, Mark, Xu, Yingju, Huffman, Mark A., Yang, Hao, Li, Hongming, Whittaker, Aaron M., Andreani, Teresa, Levesque, Francois, Fryszkowska, Anna, Brunskill, Andrew, Tschaen, David M., Maloney, Kevin M.
Published in Organic letters (19.06.2020)
Published in Organic letters (19.06.2020)
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Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
Shaw, Megan H., Fryszkowska, Anna, Alvizo, Oscar, Attadgie, Ilana, Borra-Garske, Margie, Devine, Paul N., Duan, Da, Grosser, Shane T., Forstater, Jacob H., Hughes, Gregory J., Maloney, Kevin M., Margelefsky, Eric L., Mattern, Keith A., Miller, Margaret T., Nawrat, Christopher C., Nazor, Jovana, Orth, Peter, Ouimet, Claire M., Robaire, Sandra A., Ruccolo, Serge, Schwalm, Erica L., Verma, Deeptak, Xiao, Li, Zhang, Victoria
Published in Organic process research & development (20.09.2024)
Published in Organic process research & development (20.09.2024)
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Journal Article
Biocatalytic oxidation of alcohols using galactose oxidase and a manganese() activator for the synthesis of islatravir
Johnson, Heather C, Zhang, Shaoguang, Fryszkowska, Anna, Ruccolo, Serge, Robaire, Sandra A, Klapars, Artis, Patel, Niki R, Whittaker, Aaron M, Huffman, Mark A, Strotman, Neil A
Published in Organic & biomolecular chemistry (25.02.2021)
Published in Organic & biomolecular chemistry (25.02.2021)
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A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
Fryszkowska, Anna, An, Chihui, Alvizo, Oscar, Banerjee, Goutami, Canada, Keith A., Cao, Yang, DeMong, Duane, Devine, Paul N., Duan, Da, Elgart, David M., Farasat, Iman, Gauthier, Donald R., Guidry, Erin N., Jia, Xiujuan, Kong, Jongrock, Kruse, Nikki, Lexa, Katrina W., Makarov, Alexey A., Mann, Benjamin F., Milczek, Erika M., Mitchell, Vesna, Nazor, Jovana, Neri, Claudia, Orr, Robert K., Orth, Peter, Phillips, Eric M., Riggins, James N., Schafer, Wes A., Silverman, Steven M., Strulson, Christopher A., Subramanian, Nandhitha, Voladri, Rama, Yang, Hao, Yang, Jie, Yi, Xiang, Zhang, Xiyun, Zhong, Wendy
Published in Science (American Association for the Advancement of Science) (17.06.2022)
Published in Science (American Association for the Advancement of Science) (17.06.2022)
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Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic 'ene'-Reductase related to Old Yellow Enzyme
Adalbjörnsson, Björn V, Toogood, Helen S, Fryszkowska, Anna, Pudney, Christopher R, Jowitt, Thomas A, Leys, David, Scrutton, Nigel S
Published in Chembiochem : a European journal of chemical biology (25.01.2010)
Published in Chembiochem : a European journal of chemical biology (25.01.2010)
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Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation
Fryszkowska, Anna, Toogood, Helen, Sakuma, Michiyo, Gardiner, John M., Stephens, Gill M., Scrutton, Nigel S.
Published in Advanced synthesis & catalysis (01.11.2009)
Published in Advanced synthesis & catalysis (01.11.2009)
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Journal Article
A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity
Toogood, Helen S., Fryszkowska, Anna, Hulley, Martyn, Sakuma, Michiyo, Mansell, David, Stephens, Gill M., Gardiner, John M., Scrutton, Nigel S.
Published in Chembiochem : a European journal of chemical biology (21.03.2011)
Published in Chembiochem : a European journal of chemical biology (21.03.2011)
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Development of a Chemoenzymatic Process for Dehydroepiandrosterone Acetate Synthesis
Fryszkowska, Anna, Peterson, Justine, Davies, Nichola L, Dewar, Colin, Evans, George, Bycroft, Matthew, Triggs, Neil, Fleming, Toni, Gorantla, Srikanth Sarat Chandra, Hoge, Garrett, Quirmbach, Michael, Timmanna, Upadhya, Reddy Poreddy, Srinivas, Kumar Reddy, D. Naresh, Dahanukar, Vilas, Holt-Tiffin, Karen E
Published in Organic process research & development (19.08.2016)
Published in Organic process research & development (19.08.2016)
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항바이러스 뉴클레오시드의 합성
MALIGRES PETER E, FIER PATRICK S, KONG JONGROCK, MURPHY GRANT S, FRYSZKOWSKA ANNA, HUFFMAN MARK A, MALONEY KEVIN M, YANG HAO, MCINTOSH JOHN, SILVERMAN STEVEN M, ITOH TETSUJI, BENKOVICS TAMAS
Year of Publication 18.08.2023
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Year of Publication 18.08.2023
Patent
Structure-Based Insight into the Asymmetric Bioreduction of the CC Double Bond of α,β-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase
Toogood, Helen S., Fryszkowska, Anna, Hare, Victoria, Fisher, Karl, Roujeinikova, Anna, Leys, David, Gardiner, John M., Stephens, Gill M., Scrutton, Nigel S.
Published in Advanced synthesis & catalysis (17.11.2008)
Published in Advanced synthesis & catalysis (17.11.2008)
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