Significant Differences in Biological Parameters between Prodrugs Cleavable by Carboxypeptidase G2 That Generate 3,5-Difluoro-phenol and -aniline Nitrogen Mustards in Gene-Directed Enzyme Prodrug Therapy Systems
Niculescu-Duvaz, I, Scanlon, I, Niculescu-Duvaz, D, Friedlos, F, Martin, J, Marais, R, Springer, C. J
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
Get full text
Journal Article
A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs
SPOONER, R. A, FRIEDLOS, F, MARAIS, R, SPRINGER, C. J, MAYCROFT, K, STRIBBLING, S. M, ROUSSEL, J, BRUEGGEN, J, STOLZ, B, O'REILLY, T, WOOD, J, MATTER, A
Published in British journal of cancer (19.05.2003)
Published in British journal of cancer (19.05.2003)
Get full text
Journal Article
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase
Anlezark, G.M., Melton, R.G., Sherwood, R.F., Wilson, W.R., Denny, W.A., Palmer, B.D., Knox, R.J., Friedlos, F., Williams, A.
Published in Biochemical pharmacology (25.08.1995)
Published in Biochemical pharmacology (25.08.1995)
Get full text
Journal Article
584 POSTER Novel inhibitors of BRAF based on a 2,6-disubstituted pyrazine scaffold
Niculescu-Duvaz, I, Roman, E, Whittaker, S.R, Friedlos, F, Kirk, R, Scanlon, I.J, Davies, L.C, Niculescu-Duvaz, D, Marais, R, Springer, C.J
Published in European journal of cancer supplements (2008)
Published in European journal of cancer supplements (2008)
Get full text
Journal Article
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
DA ROCHA DIAS, Silvy, FRIEDLOS, Frank, LIGHT, Yvonne, SPRINGER, Caroline, WORKMAN, Paul, MARAIS, Richard
Published in Cancer research (Chicago, Ill.) (01.12.2005)
Published in Cancer research (Chicago, Ill.) (01.12.2005)
Get full text
Journal Article
Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes
Chen, S, Knox, R, Lewis, A D, Friedlos, F, Workman, P, Deng, P S, Fung, M, Ebenstein, D, Wu, K, Tsai, T M
Published in Molecular pharmacology (01.05.1995)
Get full text
Published in Molecular pharmacology (01.05.1995)
Journal Article
B-RAF is a therapeutic target in melanoma
KARASARIDES, Maria, CHILOECHES, Antonio, SPRINGER, Caroline J, MARAIS, Richard, HAYWARD, Robert, NICULESCU-DUVAZ, Dan, SCANLON, Ian, FRIEDLOS, Frank, OGILVIE, Lesley, HEDLEY, Douglas, MARTIN, Jan, MARSHALL, Christopher J
Published in Oncogene (19.08.2004)
Published in Oncogene (19.08.2004)
Get full text
Journal Article
Sensitisation of human ovarian cancer cells to killing by the prodrug CB1954 following retroviral or adenoviral transfer of the E. coli nitroreductase gene
Searle, P F, Weedon, S J, McNeish, I A, Gilligan, M G, Ford, M J, Friedlos, F, Springer, C J, Young, L S, Kerr, D J
Published in Advances in experimental medicine and biology (1998)
Published in Advances in experimental medicine and biology (1998)
Get more information
Journal Article
Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead
Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R, Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J, Davies, Lawrence C, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
Get full text
Journal Article
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2
SCHEPELMANN, Silke, HALLENBECK, Paul, SPRINGER, Caroline J, OGILVIE, Lesley M, HEDLEY, Douglas, FRIEDLOS, Frank, MARTIN, Janet, SCANLON, Ian, HAY, Carl, HAWKINS, Lynda K, MARAIS, Richard
Published in Cancer research (Chicago, Ill.) (15.06.2005)
Published in Cancer research (Chicago, Ill.) (15.06.2005)
Get full text
Journal Article
Novel Fluorinated Prodrugs for Activation by Carboxypeptidase G2 Showing Good in Vivo Antitumor Activity in Gene-Directed Enzyme Prodrug Therapy
Davies, Lawrence C, Friedlos, Frank, Hedley, Douglas, Martin, Jan, Ogilvie, Lesley M, Scanlon, Ian J, Springer, Caroline J
Published in Journal of medicinal chemistry (11.08.2005)
Published in Journal of medicinal chemistry (11.08.2005)
Get full text
Journal Article
Self-Immolative Nitrogen Mustards Prodrugs Cleavable by Carboxypeptidase G2 (CPG2) Showing Large Cytotoxicity Differentials in GDEPT
Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Friedlos, Frank, Martin, Jan, Lehouritis, Panos, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (24.04.2003)
Published in Journal of medicinal chemistry (24.04.2003)
Get full text
Journal Article
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
FRIEDLOS, Frank, DAVIES, Lawrence, SCANLON, Ian, OGILVIE, Lesley M, MARTIN, Janet, STRIBBLING, Stephen M, SPOONER, Robert A, NICULESCU-DUVAZ, Ion, MARAIS, Richard, SPRINGER, Caroline J
Published in Cancer research (Chicago, Ill.) (15.03.2002)
Get full text
Published in Cancer research (Chicago, Ill.) (15.03.2002)
Journal Article
The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents
Knox, R.J., Lydall, D.A., Friedlos, F., Basham, C., Roberts, J.J.
Published in Biochimica et biophysica acta (29.04.1987)
Published in Biochimica et biophysica acta (29.04.1987)
Get full text
Journal Article
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
Anlezark, G M, Melton, R G, Sherwood, R F, Coles, B, Friedlos, F, Knox, R J
Published in Biochemical pharmacology (15.12.1992)
Published in Biochemical pharmacology (15.12.1992)
Get more information
Journal Article
Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect
Stribbling, S M, Friedlos, F, Martin, J, Davies, L, Spooner, R A, Marais, R, Springer, C J
Published in Human gene therapy (20.01.2000)
Published in Human gene therapy (20.01.2000)
Get more information
Journal Article