Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV‑2 nsp3
Frick, David N, Virdi, Rajdeep S, Vuksanovic, Nemanja, Dahal, Narayan, Silvaggi, Nicholas R
Published in Biochemistry (21.07.2020)
Published in Biochemistry (21.07.2020)
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Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication
Bassetto, Marcella, Leyssen, Pieter, Neyts, Johan, Yerukhimovich, Mark M., Frick, David N., Brancale, Andrea
Published in European journal of medicinal chemistry (10.11.2016)
Published in European journal of medicinal chemistry (10.11.2016)
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Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
MASTRANGELO, Eloise, PEZZULLO, Margherita, BOLOGNESI, Martino, MILANI, Mario, DE BURGHGRAEVE, Tine, KAPTEIN, Suzanne, PASTORINO, Boris, DALLMEIER, Kai, DE LAMBALLERIE, Xavier, NEYTS, Johan, HANSON, Alicia M, FRICK, David N
Published in Journal of antimicrobial chemotherapy (01.08.2012)
Published in Journal of antimicrobial chemotherapy (01.08.2012)
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Discovering new medicines targeting helicases: challenges and recent progress
Shadrick, William R, Ndjomou, Jean, Kolli, Rajesh, Mukherjee, Sourav, Hanson, Alicia M, Frick, David N
Published in Journal of biomolecular screening (01.08.2013)
Published in Journal of biomolecular screening (01.08.2013)
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Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV
Bassetto, Marcella, Leyssen, Pieter, Neyts, Johan, Yerukhimovich, Mark M., Frick, David N., Brancale, Andrea
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase
Bassetto, Marcella, Leyssen, Pieter, Neyts, Johan, Yerukhimovich, Mark M., Frick, David N., Courtney-Smith, Matthew, Brancale, Andrea
Published in European journal of medicinal chemistry (05.01.2017)
Published in European journal of medicinal chemistry (05.01.2017)
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Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice
Belayet, Jawad B, Beamish, Sarah, Rahaman, Mizzanoor, Alanani, Samer, Virdi, Rajdeep S, Frick, David N, Rahman, A. F. M. Towheedur, Ulicki, Joseph S, Biswas, Sreya, Arnold, Leggy A, Roni, M. S. Rashid, Cheng, Eric Y, Steeber, Douglas A, Frick, Karyn M, Hossain, M. Mahmun
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells
Corby, M.J., Stoneman, Michael R., Biener, Gabriel, Paprocki, Joel D., Kolli, Rajesh, Raicu, Valerica, Frick, David N.
Published in The Journal of biological chemistry (07.07.2017)
Published in The Journal of biological chemistry (07.07.2017)
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Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient
Provazzi, Paola J S, Mukherjee, Sourav, Hanson, Alicia M, Nogueira, Mauricio L, Carneiro, Bruno M, Frick, David N, Rahal, Paula
Published in PloS one (10.12.2015)
Published in PloS one (10.12.2015)
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Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
Mukherjee, Sourav, Hanson, Alicia M, Shadrick, William R, Ndjomou, Jean, Sweeney, Noreena L, Hernandez, John J, Bartczak, Diana, Li, Kelin, Frankowski, Kevin J, Heck, Julie A, Arnold, Leggy A, Schoenen, Frank J, Frick, David N
Published in Nucleic acids research (01.09.2012)
Published in Nucleic acids research (01.09.2012)
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Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline
Li, Kelin, Frankowski, Kevin J, Belon, Craig A, Neuenswander, Ben, Ndjomou, Jean, Hanson, Alicia M, Shanahan, Matthew A, Schoenen, Frank J, Blagg, Brian S. J, Aubé, Jeffrey, Frick, David N
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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