Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
Roberts, Jason A, Prof, Abdul-Aziz, Mohd H, BPharm, Lipman, Jeffrey, Prof, Mouton, Johan W, Prof, Vinks, Alexander A, Prof, Felton, Timothy W, Dr, Hope, William W, Prof, Farkas, Andras, Dr, Neely, Michael N, MD, Schentag, Jerome J, Dr, Drusano, George, Prof, Frey, Otto R, Dr, Theuretzbacher, Ursula, Dr, Kuti, Joseph L, Dr
Published in The Lancet infectious diseases (01.06.2014)
Published in The Lancet infectious diseases (01.06.2014)
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The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study
Roberts, Jason A, Joynt, Gavin M, Lee, Anna, Choi, Gordon, Bellomo, Rinaldo, Kanji, Salmaan, Mudaliar, M Yugan, Peake, Sandra L, Stephens, Dianne, Taccone, Fabio Silvio, Ulldemolins, Marta, Valkonen, Miia Maaria, Agbeve, Julius, Baptista, João P, Bekos, Vasileios, Boidin, Clement, Brinkmann, Alexander, Buizen, Luke, Castro, Pedro, Cole, C Louise, Creteur, Jacques, De Waele, Jan J, Deans, Renae, Eastwood, Glenn M, Escobar, Leslie, Gomersall, Charles, Gresham, Rebecca, Jamal, Janattul Ain, Kluge, Stefan, König, Christina, Koulouras, Vasilios P, Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lei, Katie, Leung, Patricia, Lefrant, Jean-Yves, Llauradó-Serra, Mireia, Martin-Loeches, Ignacio, Mat Nor, Mohd Basri, Ostermann, Marlies, Parker, Suzanne L, Rello, Jordi, Roberts, Darren M, Roberts, Michael S, Richards, Brent, Rodríguez, Alejandro, Roehr, Anka C, Roger, Claire, Seoane, Leonardo, Sinnollareddy, Mahipal, Sousa, Eduardo, Soy, Dolors, Spring, Anna, Starr, Therese, Thomas, Jane, Turnidge, John, Wallis, Steven C, Williams, Tricia, Wittebole, Xavier, Zikou, Xanthi T, Paul, Sanjoy K, Lipman, Jeffrey
Published in Clinical infectious diseases (26.04.2021)
Published in Clinical infectious diseases (26.04.2021)
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Journal Article
Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model
Minichmayr, Iris K, Roberts, Jason A, Frey, Otto R, Roehr, Anka C, Kloft, Charlotte, Brinkmann, Alexander
Published in Journal of antimicrobial chemotherapy (01.05.2018)
Published in Journal of antimicrobial chemotherapy (01.05.2018)
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Journal Article
Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study
Blassmann, Ute, Roehr, Anka C, Frey, Otto R, Vetter-Kerkhoff, Cornelia, Thon, Niklas, Hope, William, Briegel, Josef, Huge, Volker
Published in Critical care (London, England) (24.10.2016)
Published in Critical care (London, England) (24.10.2016)
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Journal Article
CSF penetration of vancomycin in critical care patients with proven or suspected ventriculitis: a prospective observational study
Blassmann, Ute, Hope, William, Roehr, Anka C, Frey, Otto R, Vetter-Kerkhoff, Cornelia, Thon, Niklas, Briegel, Josef, Huge, Volker
Published in Journal of antimicrobial chemotherapy (01.04.2019)
Published in Journal of antimicrobial chemotherapy (01.04.2019)
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Journal Article
Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia: A retrospective analysis on pharmacokinetics and pharmacokinetic target attainment
Chiriac, Ute, Frey, Otto R, Roehr, Anka C, Koeberer, Andreas, Gronau, Patrick, Fuchs, Thomas, Roberts, Jason A, Brinkmann, Alexander
Published in Medicine (Baltimore) (04.06.2021)
Published in Medicine (Baltimore) (04.06.2021)
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Journal Article
In vitro removal of anti-infective agents by a novel cytokine adsorbent system
König, Christina, Röhr, Anka C, Frey, Otto R, Brinkmann, Alexander, Roberts, Jason A, Wichmann, Dominic, Braune, Stephan, Kluge, Stefan, Nierhaus, Axel
Published in International journal of artificial organs (01.02.2019)
Published in International journal of artificial organs (01.02.2019)
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Journal Article
Linezolid in liver failure: exploring the value of the maximal liver function capacity (LiMAx) test in a pharmacokinetic pilot study
Wicha, Sebastian G., Frey, Otto R., Roehr, Anka C., Pratschke, Johann, Stockmann, Martin, Alraish, Rawan, Wuensch, Tilo, Kaffarnik, Magnus
Published in International journal of antimicrobial agents (01.10.2017)
Published in International journal of antimicrobial agents (01.10.2017)
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Journal Article
Excessive unbound cefazolin concentrations in critically ill patients receiving veno-arterial extracorporeal membrane oxygenation (vaECMO): an observational study
Booke, Hendrik, Frey, Otto R., Röhr, Anka C., Chiriac, Ute, Zacharowski, Kai, Holubec, Tomas, Adam, Elisabeth H.
Published in Scientific reports (20.08.2021)
Published in Scientific reports (20.08.2021)
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Journal Article
Population pharmacokinetics and toxicodynamics of continuously infused linezolid in critically ill patients
Wicha, Sebastian G., Mair, Andrea, Chiriac, Ute, Frey, Otto R., Fuchs, Thomas, Gaasch, Max, Hagel, Stefan, Richter, Daniel C., Roberts, Jason A., Röhr, Anka C., Weigand, Markus A., Brinkmann, Alexander
Published in International journal of antimicrobial agents (01.05.2022)
Published in International journal of antimicrobial agents (01.05.2022)
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Journal Article
Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis
König, Christina, Braune, Stephan, Roberts, Jason A, Nierhaus, Axel, Steinmetz, Oliver M, Baehr, Michael, Frey, Otto R, Langebrake, Claudia, Kluge, Stefan
Published in Journal of antimicrobial chemotherapy (01.05.2017)
Published in Journal of antimicrobial chemotherapy (01.05.2017)
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Journal Article
Liver function, quantified by the LiMAx test, as a predictor for the clinical outcome of critically ill patients treated with linezolid
Alraish, Rawan, Wicha, Sebastian G, Frey, Otto R, Roehr, Anka C, Pratschke, Johann, Stockmann, Martin, Wuensch, Tilo, Kaffarnik, Magnus
Published in Technology and health care (01.01.2022)
Published in Technology and health care (01.01.2022)
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Journal Article
Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice for patients undergoing major abdominal surgery
Murtha-Lemekhova, Anastasia, Fuchs, Juri, Teroerde, Miriam, Rau, Heike, Frey, Otto R, Hornuss, Daniel, Billeter, Adrian, Klotz, Rosa, Chiriac, Ute, Larmann, Jan, Weigand, Markus A, Probst, Pascal, Hoffmann, Katrin
Published in BMJ open (19.09.2022)
Published in BMJ open (19.09.2022)
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Journal Article
Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial
Hagel, Stefan, Fiedler, Sandra, Hohn, Andreas, Brinkmann, Alexander, Frey, Otto R, Hoyer, Heike, Schlattmann, Peter, Kiehntopf, Michael, Roberts, Jason A, Pletz, Mathias W
Published in Current controlled trials in cardiovascular medicine (06.06.2019)
Published in Current controlled trials in cardiovascular medicine (06.06.2019)
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Journal Article
What Are the Predictors for Achieving Therapeutic Levetiracetam Serum Concentrations in Adult Neurological Patients?
Cotta, Menino O, Abdul-Aziz, Mohd H, Frey, Otto R, Sime, Fekade B, Roberts, Jason A, Roehr, Anka C
Published in Therapeutic drug monitoring (01.08.2020)
Published in Therapeutic drug monitoring (01.08.2020)
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Journal Article
Ciprofloxacin in Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO): A Population Pharmacokinetic Study
Alihodzic, Dzenefa, Wicha, Sebastian G, Frey, Otto R, König, Christina, Baehr, Michael, Jarczak, Dominik, Kluge, Stefan, Langebrake, Claudia
Published in Pharmaceutics (29.04.2022)
Published in Pharmaceutics (29.04.2022)
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Journal Article
Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance
König, Christina, Both, Anna, Rohde, Holger, Kluge, Stefan, Frey, Otto R., Röhr, Anka C., Wichmann, Dominic
Published in Antibiotics (Basel) (28.05.2021)
Published in Antibiotics (Basel) (28.05.2021)
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Journal Article
What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?
Alobaid, Abdulaziz S, Brinkmann, Alexander, Frey, Otto R, Roehr, Anka C, Luque, Sonia, Grau, Santiago, Wong, Gloria, Abdul-Aziz, Mohd-Hafiz, Roberts, Michael S, Lipman, Jeffrey, Roberts, Jason A
Published in Journal of antimicrobial chemotherapy (01.03.2016)
Published in Journal of antimicrobial chemotherapy (01.03.2016)
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Journal Article
Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)
Alraish, Rawan, Wicha, Sebastian G., Frey, Otto R., Roehr, Anka C., Pratschke, Johann, Stockmann, Martin, Wuensch, Tilo, Kaffarnik, Magnus
Published in Annals of intensive care (04.08.2020)
Published in Annals of intensive care (04.08.2020)
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