Non-destructive and Selective Imaging of the Functionally Active, Pro-invasive Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Enzyme in Cancer Cells
Remacle, Albert G., Shiryaev, Sergey A., Golubkov, Vladislav S., Freskos, John N., Brown, Michael A., Karwa, Amolkumar S., Naik, Arati D., Howard, Carol P., Sympson, Carolyn J., Strongin, Alex Y.
Published in The Journal of biological chemistry (12.07.2013)
Published in The Journal of biological chemistry (12.07.2013)
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Multicompartment Polymer Nanostructures with Ratiometric Dual-Emission pH-Sensitivity
Sun, Guorong, Cui, Honggang, Lin, Lily Yun, Lee, Nam S, Yang, Chao, Neumann, William L, Freskos, John N, Shieh, Jeng J, Dorshow, Richard B, Wooley, Karen L
Published in Journal of the American Chemical Society (08.06.2011)
Published in Journal of the American Chemical Society (08.06.2011)
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Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease
Becker, Daniel P, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, Bond, Brian R, Carroll, Jeffery, Carron, Chris P, DeCrescenzo, Gary A, Easton, Alan M, Freskos, John N, Funckes-Shippy, Chris L, Heron, Marcia, Hockerman, Susan, Howard, Carol Pearcy, Kiefer, James R, Li, Madeleine H, Mathis, Karl J, McDonald, Joseph J, Mehta, Pramod P, Munie, Grace E, Sunyer, Teresa, Swearingen, Craig A, Villamil, Clara I, Welsch, Dean, Williams, Jennifer M, Yu, Ying, Yao, Jun
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
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Hydrophilic Pyrazine Dyes as Exogenous Fluorescent Tracer Agents for Real-Time Point-of-Care Measurement of Glomerular Filtration Rate
Rajagopalan, Raghavan, Neumann, William L, Poreddy, Amruta R, Fitch, Richard M, Freskos, John N, Asmelash, Bethel, Gaston, Kimberly R, Galen, Karen P, Shieh, Jeng-Jong, Dorshow, Richard B
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate
Poreddy, Amruta R., Neumann, William L., Freskos, John N., Rajagopalan, Raghavan, Asmelash, Bethel, Gaston, Kimberly R., Fitch, Richard M., Galen, Karen P., Shieh, Jeng-Jong, Dorshow, Richard B.
Published in Bioorganic & medicinal chemistry (15.04.2012)
Published in Bioorganic & medicinal chemistry (15.04.2012)
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Influence of Nanostructure Morphology on Host Capacity and Kinetics of Guest Release
Lee, Nam S., Lin, Lily Yun, Neumann, William L., Freskos, John N., Karwa, Amolkumar, Shieh, Jeng J., Dorshow, Richard B., Wooley, Karen L.
Published in Small (Weinheim an der Bergstrasse, Germany) (18.07.2011)
Published in Small (Weinheim an der Bergstrasse, Germany) (18.07.2011)
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Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
Freskos, John N., Asmelash, Bethel, Gaston, Kimberly R., Karwa, Amol, Marzan, Tim A., Nickols, Maureen A., Rogers, Thomas E., Schoenstein, Tasha, Sympson, Carolyn J., Vu, Bich
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
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MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides
Fobian, Yvette M., Freskos, John N., Barta, Thomas E., Bedell, Louis J., Heintz, Robert, Kassab, Darren J., Kiefer, James R., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick, Munie, Grace E., Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy
Becker, Daniel P, Villamil, Clara I, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, DeCrescenzo, Gary A, Freskos, John N, Getman, Daniel P, Hockerman, Susan, Heintz, Robert, Howard, Susan Carol, Li, Madeleine H, McDonald, Joseph J, Carron, Chris P, Funckes-Shippy, Chris L, Mehta, Pramod P, Munie, Grace E, Swearingen, Craig A
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Journal Article
Design of potent inhibitors of human β-secretase. Part 1
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)
Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system
Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Design of potent inhibitors of human β-secretase. Part 2
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors
Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Inhibitors of HIV-1 Protease Containing the Novel and Potent (R)-(Hydroxyethyl)sulfonamide Isostere
Vazquez, Michael L, Bryant, Martin L, Clare, Michael, DeCrescenzo, Gary A, Doherty, Elizabeth M, Freskos, John N, Getman, Daniel P, Houseman, Kathryn A, Julien, Janet A, Kocan, Geralyn P, Mueller, Richard A, Shieh, Huey-Sheng, Stallings, William C, Stegeman, Roderick A, Tilley, John J
Published in Journal of medicinal chemistry (01.02.1995)
Published in Journal of medicinal chemistry (01.02.1995)
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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one
Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Tunable dual-emitting shell-crosslinked nano-objects as single-component ratiometric pH-sensing materials
Lee, Nam S, Sun, Guorong, Lin, Lily Yun, Neumann, William L, Freskos, John N, Karwa, Amolkumar, Shieh, Jeng J, Dorshow, Richard B, Wooley, Karen L
Published in Journal of materials chemistry (01.01.2011)
Published in Journal of materials chemistry (01.01.2011)
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