Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle
Biebl, Maximilian M., Lopez, Abraham, Rehn, Alexandra, Freiburger, Lee, Lawatscheck, Jannis, Blank, Birgit, Sattler, Michael, Buchner, Johannes
Published in Nature communications (05.02.2021)
Published in Nature communications (05.02.2021)
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Journal Article
Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein
Lorenz, Oliver Robin, Freiburger, Lee, Rutz, Daniel Andreas, Krause, Maike, Zierer, Bettina Karolina, Alvira, Sara, Cuéllar, Jorge, Valpuesta, José María, Madl, Tobias, Sattler, Michael, Buchner, Johannes
Published in Molecular cell (20.03.2014)
Published in Molecular cell (20.03.2014)
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Journal Article
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease
Riebold, Mathias, Kozany, Christian, Freiburger, Lee, Sattler, Michael, Buchfelder, Michael, Hausch, Felix, Stalla, Günter K, Paez-Pereda, Marcelo
Published in Nature medicine (01.03.2015)
Published in Nature medicine (01.03.2015)
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Journal Article
A switch point in the molecular chaperone Hsp90 responding to client interaction
Rutz, Daniel Andreas, Luo, Qi, Freiburger, Lee, Madl, Tobias, Kaila, Ville R. I., Sattler, Michael, Buchner, Johannes
Published in Nature communications (16.04.2018)
Published in Nature communications (16.04.2018)
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Journal Article
A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
Colaluca, Ivan Nicola, Basile, Andrea, Freiburger, Lee, D'Uva, Veronica, Disalvatore, Davide, Vecchi, Manuela, Confalonieri, Stefano, Tosoni, Daniela, Cecatiello, Valentina, Malabarba, Maria Grazia, Yang, Chun-Jiun, Kainosho, Masatsune, Sattler, Michael, Mapelli, Marina, Pece, Salvatore, Di Fiore, Pier Paolo
Published in The Journal of cell biology (05.02.2018)
Published in The Journal of cell biology (05.02.2018)
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Journal Article
Elucidating Protein Binding Mechanisms by Variable-c ITC
Freiburger, Lee A, Auclair, Karine, Mittermaier, Anthony K
Published in Chembiochem : a European journal of chemical biology (14.12.2009)
Published in Chembiochem : a European journal of chemical biology (14.12.2009)
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Journal Article
Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions
Zierer, Bettina K., Weiwad, Matthias, Rübbelke, Martin, Freiburger, Lee, Fischer, Gunter, Lorenz, Oliver R., Sattler, Michael, Richter, Klaus, Buchner, Johannes
Published in Angewandte Chemie International Edition (03.11.2014)
Published in Angewandte Chemie International Edition (03.11.2014)
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Journal Article
Van't Hoff global analyses of variable temperature isothermal titration calorimetry data
Freiburger, Lee A, Auclair, Karine, Mittermaier, Anthony K
Published in Thermochimica acta (10.01.2012)
Published in Thermochimica acta (10.01.2012)
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Journal Article
Global ITC fitting methods in studies of protein allostery
Freiburger, Lee, Auclair, Karine, Mittermaier, Anthony
Published in Methods (San Diego, Calif.) (01.04.2015)
Published in Methods (San Diego, Calif.) (01.04.2015)
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Journal Article
Efficient segmental isotope labeling of multi-domain proteins using Sortase A
Freiburger, Lee, Sonntag, Miriam, Hennig, Janosch, Li, Jian, Zou, Peijian, Sattler, Michael
Published in Journal of biomolecular NMR (01.09.2015)
Published in Journal of biomolecular NMR (01.09.2015)
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Journal Article
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network
Lopez, Abraham, Dahiya, Vinay, Delhommel, Florent, Freiburger, Lee, Stehle, Ralf, Asami, Sam, Rutz, Daniel, Blair, Laura, Buchner, Johannes, Sattler, Michael
Published in Science advances (17.12.2021)
Published in Science advances (17.12.2021)
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Journal Article
Abstract 1737: Understanding the geometry and valency of bispecific antibodies in the optimization of tumor-dependent activation of 4-1BB
von Rossum, Anna, Pratap, Harsh, Newhook, Lisa, Halvorsen, Elizabeth C., Freiburger, Lee, Duan, Renee, Stevens, Charles, Tcaciuc, Dimitri, Volkers, Gesa, Browman, Duncan, Clavette, Brandon, Mills, David, Spreter, Thomas, Patton, Daniel T.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
안정화된 TCR 작제물 및 사용 방법
FARBER PATRICK, FREIBURGER LEE, PATTON DANIEL T, PRESTA LEONARD G, ESCOBAR CABRERA ERIC, STEVENS CHARLES MICHAEL
Year of Publication 23.08.2023
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Year of Publication 23.08.2023
Patent
Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6‘-N-Acetyltransferase
Magalhães, Maria L. B, Vetting, Matthew W, Gao, Feng, Freiburger, Lee, Auclair, Karine, Blanchard, John S
Published in Biochemistry (Easton) (15.01.2008)
Published in Biochemistry (Easton) (15.01.2008)
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Journal Article
4-1BB 및 종양-관련 항원에 결합하는 항체 작제물 및 이의 용도
DUAN ZHUANG, JANCOWSKI SYLWIA, CHAN PETER WING YIU, PATTON DANIEL T, BROWMAN DUNCAN, ZWIERZCHOWSKI PATRICIA, VOLKERS GESA, VON ROSSUM ANNA, GENE ROBERT WILLIAM, FREIBURGER LEE, CHUI DANNY, HALVORSEN ELIZABETH, SPRETER VON KREUDENSTEIN THOMAS, UROSEV DUNJA, KANG SUKHBIR SINGH, CLAVETTE BRANDON, MILLS DAVID M, PRATAP HARSH
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent