STAT3 Hyper-IgE Syndrome—an Update and Unanswered Questions
Tsilifis, Christo, Freeman, Alexandra F., Gennery, Andrew R.
Published in Journal of clinical immunology (01.07.2021)
Published in Journal of clinical immunology (01.07.2021)
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Journal Article
Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report
Kim, Doyoung, Kobayashi, Tetsuro, Voisin, Benjamin, Jo, Jay-Hyun, Sakamoto, Keiko, Jin, Seon-Pil, Kelly, Michael, Pasieka, Helena B., Naff, Jessica L., Meyerle, Jon H., Ikpeama, Ijeoma D., Fahle, Gary A., Davis, Fred P., Rosenzweig, Sergio D., Alejo, Julie C., Pittaluga, Stefania, Kong, Heidi H., Freeman, Alexandra F., Nagao, Keisuke
Published in Nature medicine (01.02.2020)
Published in Nature medicine (01.02.2020)
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Journal Article
A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory
Siegel, Andrea M., Heimall, Jennifer, Freeman, Alexandra F., Hsu, Amy P., Brittain, Erica, Brenchley, Jason M., Douek, Daniel C., Fahle, Gary H., Cohen, Jeffrey I., Holland, Steven M., Milner, Joshua D.
Published in Immunity (Cambridge, Mass.) (23.11.2011)
Published in Immunity (Cambridge, Mass.) (23.11.2011)
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Journal Article
Hyper-IgE syndrome update
Sowerwine, Kathryn J., Holland, Steven M., Freeman, Alexandra F.
Published in Annals of the New York Academy of Sciences (01.02.2012)
Published in Annals of the New York Academy of Sciences (01.02.2012)
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Journal Article
Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea
Ma, Chi A., Xi, Liqiang, Cauff, Brian, DeZure, Adam, Freeman, Alexandra F., Hambleton, Sophie, Kleiner, Gary, Leahy, T.Ronan, O'Sullivan, Maureen, Makiya, Michelle, O'Regan, Grainne, Pittaluga, Stefania, Niemela, Julie, Stoddard, Jennifer, Rosenzweig, Sergio D., Raffeld, Mark, Klion, Amy D., Milner, Joshua D.
Published in Blood (02.02.2017)
Published in Blood (02.02.2017)
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Journal Article
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4⁺ T cells
Wan, Chi-Keung, Andraski, Allison B., Spolski, Rosanne, Li, Peng, Kazemian, Majid, Oh, Jangsuk, Samsel, Leigh, Swanson, Phillip A., McGavern, Dorian B., Sampaio, Elizabeth P., Freeman, Alexandra F., Milner, Joshua D., Holland, Steven M., Leonard, Warren J.
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
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Journal Article
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity
Zhang, Qian, Dove, Christopher G, Hor, Jyh Liang, Murdock, Heardley M, Strauss-Albee, Dara M, Garcia, Jordan A, Mandl, Judith N, Grodick, Rachael A, Jing, Huie, Chandler-Brown, Devon B, Lenardo, Timothy E, Crawford, Greg, Matthews, Helen F, Freeman, Alexandra F, Cornall, Richard J, Germain, Ronald N, Mueller, Scott N, Su, Helen C
Published in The Journal of experimental medicine (15.12.2014)
Published in The Journal of experimental medicine (15.12.2014)
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Journal Article
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis
Hox, Valerie, MD, PhD, O'Connell, Michael P., PhD, Lyons, Jonathan J., MD, Sackstein, Paul, BS, Dimaggio, Thomas, ADN, RN, Jones, Nina, BSN, RN, Nelson, Celeste, MS CRNP, Boehm, Manfred, MD, Holland, Steven M., MD, Freeman, Alexandra F., MD, Tweardy, David J., MD, Olivera, Ana, PhD, Metcalfe, Dean D., MD, Milner, Joshua D., MD
Published in Journal of allergy and clinical immunology (01.07.2016)
Published in Journal of allergy and clinical immunology (01.07.2016)
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Journal Article
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients
Zhang, Yuan, Ma, Chi A, Lawrence, Monica G, Break, Timothy J, O'Connell, Michael P, Lyons, Jonathan J, López, Diego B, Barber, John S, Zhao, Yongge, Barber, Daniel L, Freeman, Alexandra F, Holland, Steven M, Lionakis, Michail S, Milner, Joshua D
Published in The Journal of experimental medicine (04.09.2017)
Published in The Journal of experimental medicine (04.09.2017)
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Journal Article
STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation
Zimmerman, Ofer, Olbrich, Peter, Freeman, Alexandra F, Rosen, Lindsey B, Uzel, Gulbu, Zerbe, Christa S, Rosenzweig, Sergio D, Kuehn, Hye Sun, Holmes, Kevin L, Stephany, David, Ding, Li, Sampaio, Elizabeth P, Hsu, Amy P, Holland, Steven M
Published in Frontiers in immunology (10.07.2019)
Published in Frontiers in immunology (10.07.2019)
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Journal Article
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation
Koganti, Siva, Hui-Yuen, Joyce, McAllister, Shane, Gardner, Benjamin, Grasser, Friedrich, Palendira, Umaimainthan, Tangye, Stuart G., Freeman, Alexandra F., Bhaduri-McIntosh, Sumita
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2014)
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Journal Article
Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency
Cuellar-Rodriguez, Jennifer, Gea-Banacloche, Juan, Freeman, Alexandra F., Hsu, Amy P., Zerbe, Christa S., Calvo, Katherine R., Wilder, Jennifer, Kurlander, Roger, Olivier, Kenneth N., Holland, Steven M., Hickstein, Dennis D.
Published in Blood (29.09.2011)
Published in Blood (29.09.2011)
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Journal Article
Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity
Squire, Jacqueline D., Libertin, Claudia R., Powers, Harry, Nelson, Jared, Brumble, Lisa, Laham, Federico R., Agharahimi, Anahita, Freeman, Alexandra F., Leiding, Jennifer W.
Published in International journal of infectious diseases (01.06.2023)
Published in International journal of infectious diseases (01.06.2023)
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Journal Article
Germline gain-of-function mutation of STAT1 rescued by somatic mosaicism in immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like disorder
Lee, Jeong Seok, An, Yohan, Yoon, Christopher J., Kim, Jeong Yeon, Kim, Kyung Hwan, Freeman, Alexandra F., Yim, Jae-Joon, Shin, Eui-Cheol, Holland, Steven M., Lee, Eun Young, Ju, Young Seok
Published in Journal of allergy and clinical immunology (01.03.2020)
Published in Journal of allergy and clinical immunology (01.03.2020)
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Journal Article
The hyper-IgE syndromes
Freeman, Alexandra F, Holland, Steven M
Published in Immunology and allergy clinics of North America (01.05.2008)
Published in Immunology and allergy clinics of North America (01.05.2008)
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Journal Article
Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature
Zerbe, Christa S., Marciano, Beatriz E., Katial, Rohit K., Santos, Carah B., Adamo, Nick, Hsu, Amy P., Hanks, Mary E., Darnell, Dirk N., Quezado, Martha M., Frein, Cathleen, Barnhart, Lisa A., Anderson, Victoria L., Uzel, Gulbu, Freeman, Alexandra F., Lisco, Andrea, Nath, Avindra, Major, Eugene O., Sampaio, Elizabeth P., Holland, Steven M.
Published in Clinical infectious diseases (15.04.2016)
Published in Clinical infectious diseases (15.04.2016)
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