VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
Keating, Dominic, Marigowda, Gautham, Burr, Lucy, Daines, Cori, Mall, Marcus A, McKone, Edward F, Ramsey, Bonnie W, Rowe, Steven M, Sass, Laura A, Tullis, Elizabeth, McKee, Charlotte M, Moskowitz, Samuel M, Robertson, Sarah, Savage, Jessica, Simard, Christopher, Van Goor, Fredrick, Waltz, David, Xuan, Fengjuan, Young, Tim, Taylor-Cousar, Jennifer L
Published in The New England journal of medicine (25.10.2018)
Published in The New England journal of medicine (25.10.2018)
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VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
Davies, Jane C, Moskowitz, Samuel M, Brown, Cynthia, Horsley, Alexander, Mall, Marcus A, McKone, Edward F, Plant, Barry J, Prais, Dario, Ramsey, Bonnie W, Taylor-Cousar, Jennifer L, Tullis, Elizabeth, Uluer, Ahmet, McKee, Charlotte M, Robertson, Sarah, Shilling, Rebecca A, Simard, Christopher, Van Goor, Fredrick, Waltz, David, Xuan, Fengjuan, Young, Tim, Rowe, Steven M
Published in The New England journal of medicine (25.10.2018)
Published in The New England journal of medicine (25.10.2018)
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VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1
Ren, Hong Yu, Grove, Diane E, De La Rosa, Oxana, Houck, Scott A, Sopha, Pattarawut, Van Goor, Fredrick, Hoffman, Beth J, Cyr, Douglas M
Published in Molecular biology of the cell (01.10.2013)
Published in Molecular biology of the cell (01.10.2013)
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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D. J, Burton, Bill, Stack, Jeffrey H, Straley, Kimberly S, Decker, Caroline J, Miller, Mark, McCartney, Jason, Olson, Eric R, Wine, Jeffrey J, Frizzell, Ray A, Ashlock, Melissa, Negulescu, Paul A
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R
Published in Nature genetics (01.10.2013)
Published in Nature genetics (01.10.2013)
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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D.J, Burton, Bill, Cao, Dong, Neuberger, Tim, Turnbull, Amanda, Singh, Ashvani, Joubran, John, Hazlewood, Anna, Zhou, Jinglan, McCartney, Jason, Arumugam, Vijayalaksmi, Decker, Caroline, Yang, Jennifer, Young, Chris, Olson, Eric R, Wine, Jeffery J, Frizzell, Raymond A, Ashlock, Melissa, Negulescu, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
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Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators
Neuberger, Timothy, Burton, Bill, Clark, Heather, Van Goor, Fredrick
Published in Methods in molecular biology (Clifton, N.J.) (2011)
Published in Methods in molecular biology (Clifton, N.J.) (2011)
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Discovery of N‑(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
Hadida, Sabine, Van Goor, Fredrick, Zhou, Jinglan, Arumugam, Vijayalaksmi, McCartney, Jason, Hazlewood, Anna, Decker, Caroline, Negulescu, Paul, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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G970R‐CFTR Mutation (c.2908G>C) Results Predominantly in a Splicing Defect
Fidler, Meredith C., Buckley, Alexandra, Sullivan, James C., Statia, Marvin, Boj, Sylvia F., Vries, Robert G. J., Munck, Anne, Higgins, Mark, Moretto Zita, Matteo, Negulescu, Paul, Goor, Fredrick, De Boeck, Kris
Published in Clinical and translational science (01.03.2021)
Published in Clinical and translational science (01.03.2021)
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Biophysical basis of pituitary cell type-specific Ca2+ signaling-secretion coupling
STOJILKOVIC, Stanko S, ZEMKOVA, Hana, VAN GOOR, Fredrick
Published in Trends in endocrinology and metabolism (01.05.2005)
Published in Trends in endocrinology and metabolism (01.05.2005)
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Multiple Roles of Gi/o Protein-coupled Receptors in Control of Action Potential Secretion Coupling in Pituitary Lactotrophs
Stojilkovic, Stanko S., Murano, Takayo, Gonzalez-Iglesias, Arturo E., Andric, Silvana A., Popovic, Marko A., Van Goor, Fredrick, Tomić, Melanija
Published in Annals of the New York Academy of Sciences (01.01.2009)
Published in Annals of the New York Academy of Sciences (01.01.2009)
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Characterization of Calcium Signaling by Purinergic Receptor-Channels Expressed in Excitable Cells
Koshimizu, T A, Van Goor, F, Tomić, M, Wong, A O, Tanoue, A, Tsujimoto, G, Stojilkovic, S S
Published in Molecular pharmacology (01.11.2000)
Published in Molecular pharmacology (01.11.2000)
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Modeling of Membrane Excitability in Gonadotropin-Releasing Hormone-Secreting Hypothalamic Neurons Regulated by Ca2+-Mobilizing and Adenylyl Cyclase-Coupled Receptors
LeBeau, Andrew P, Van Goor, Fredrick, Stojilkovic, Stanko S, Sherman, Arthur
Published in The Journal of neuroscience (15.12.2000)
Published in The Journal of neuroscience (15.12.2000)
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Coordinate Regulation of Gonadotropin-Releasing Hormone Neuronal Firing Patterns by Cytosolic Calcium and Store Depletion
Van Goor, Fredrick, Krsmanovic, Lazar Z., Catt, Kevin J., Stojilkovic, Stanko S.
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.1999)
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Amplitude-dependent spike-broadening and enhanced Ca(2+) signaling in GnRH-secreting neurons
Van Goor, F, LeBeau, A P, Krsmanovic, L Z, Sherman, A, Catt, K J, Stojilkovic, S S
Published in Biophysical journal (01.09.2000)
Published in Biophysical journal (01.09.2000)
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Ivacaftor potentiation of multiple CFTR channels with gating mutations
Yu, Haihui, Burton, Bill, Huang, Chien-Jung, Worley, Jennings, Cao, Dong, Johnson, James P, Urrutia, Art, Joubran, John, Seepersaud, Sheila, Sussky, Katherine, Hoffman, Beth J, Van Goor, Fredrick
Published in Journal of cystic fibrosis (01.05.2012)
Published in Journal of cystic fibrosis (01.05.2012)
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